CAS: 80471-63-2; 4α,5α-Epoxy-3,17β-Dihydroxy-4β,17α-Dimethyl-5α-Androst-2-Ene-2-Carbonitrile

专利信息

专利号:EP-0296097-B1
优先权日:1987-06-16
标 题:Medicine containing inhibitors of the progesterone synthesis of the trilostane or epostane type and antigestagens
摘要:The medicine contains a progesterone synthesis inhibitor (ProH) of the trilostane or epostane type and an antigestagen (AG) and is used for inducing labour at term in humans and animals and for terminating normal or pathological pregnancy. The combination according to the invention is also suitable for treating hormone-dependent tumours, endometriosis and dysmenorrhoea.

专利号:EP-1886695-A1
优先权日:2006-06-27
标 题:Pharmaceutical combination of an aldosterone synthase inhibitor and a glucocorticoid receptor antagonist or a cortisol synthesis inhibitor or a corticotropin releasing factor antagonist
发明人：SCHUMACHER CHRISTOPH
权利人:SPEEDEL EXPERIMENTA AG
摘要:The invention relates to a pharmaceutical combination comprising (a) an aldosterone synthase inhibitor or a pharmaceutically acceptable salt thereof, and (b) a glucocorticoid receptor antagonist or a cortisol synthesis inhibitor or a cortisol re-synthesis inhibitor or a corticotrophin-releasing hormone receptor antagonist or combinations thereof or in each case a pharmaceutically acceptable salt thereof. Said composition is useful for the manufacture of a medicament, in particular for the manufacture of a medicament for the prevention of, delay of progression of treatment of a disease or condition characterized by the metabolic syndrome.

专利号:US-5795881-A
优先权日:1987-06-16
标 题:Combined use of an antigestagen and a progesterone synthesis inhibitor of the trilostane and epostane type
发明人：ELGER WALTER; BEIER SYBILLE; KOSUB BEATE; FAEHNRICH MARIANNE; CHWALISZ KRZYSZTOF; HASAN SYED HAMIDUDDIN; POTTS GORDON OLIVER
权利人:SCHERING AG
摘要:A pharmaceutical agent contains a progesterone synthesis inhibitor (ProI) of the trilostane or epostane type and an antigestagen (AG). It can be used for inducing delivery at term in humans and animals, for terminating normal or pathological pregnancies therein or for treatment of hormone-dependent tumors, endometriosis or dysmenorrhea.

专利号:US-6225298-B1
优先权日:1994-11-22
标 题 :Compositions and methods for contraception and for treatment of benign gynecological disorders
发明人：SPICER DARCY V; PIKE MALCOLM CECIL; DANIELS JOHN R
权利人:BALANCE PHARMACEUTICALS INC
摘要:Compositions and methods for use in preventing conception or treating benign gynecological disorders, wherein an effective amount of an antiprogestational agent [e.g., progesterone (progestin, progestogen, gestagen) antagonist or progesterone synthesis inhibitor] administered over a first period of time is combined with an effective amount of a progestogen for a second period of time. The antiprogestational agent is selected from single agents or mixtures thereof. The progestogen is selected from single agents or mixtures of natural or synthetic progestogens. The formulations are effective as contraceptive agents and for treatment of benign gynecological disorders including uterine fibroids, premenstrual syndrome, dysfunctional uterine bleeding, polycystic ovarian syndrome and endometriosis.

专利号:US-2001016578-A1
优先权日:1997-06-18
标 题 :Compositions and methods for contraception and for treatment of benign gynecological disorders
发明人：SPICER DARCY V; PIKE MALCOLM CECIL; DANIELS JOHN R
权利人:BALANCE PHARMACEUTICALS INC
摘要:Compositions and methods for use in preventing conception or treating benign gynecological disorders, wherein an effective amount of an antiprogestational agent [e.g., progesterone (progestin, progestogen, gestagen) antagonist or progesterone synthesis inhibitor] administered over a first period of time is combined with an effective amount of a progestogen for a second period of time. The antiprogestational agent is selected from single agents or mixtures thereof. The progestogen is selected from single agents or mixtures of natural or synthetic progestogens. The formulations are effective as contraceptive agents and for treatment of benign gynecological disorders including uterine fibroids, premenstrual syndrome, dysfunctional uterine bleeding, polycystic ovarian syndrome and endometriosis.

专利号:EP-0296097-A3
优先权日:1987-06-16
标题:Medicine containing inhibitors of the progesterone synthesis of the trilostane or epostane type and antigestagens