CAS: 6197-39-3; Methyl 1,2,5,6-Tetrahydropyridine-3-Carboxylate Hydrochloride

📜氢溴酸槟榔碱置于1-氯乙基氯甲酸酯,Sodium Carbonate,1,2-二氯乙烷体系中,用 二氯甲烷,水 作为反应溶剂,化学反应 6.25H,反应生成 1,2,5,6-四氢吡啶-3-甲酸甲酯盐酸盐
参考文献:N-Heteroarylmethyl-5-Hydroxy-1,2,5,6-Tetrahydropyridine-3-Carboxylic Acid A Novel Scaffold For The Design Of Uncompetitive α-Glucosidase Inhibitors
标题:N-Heteroarylmethyl-5-Hydroxy-1,2,5,6-Tetrahydropyridine-3-Carboxylic Acid A Novel Scaffold For The Design Of Uncompetitive α-Glucosidase Inhibitors
摘要:The Enzyme Alpha-Glucosidase Has Attracted Interest Owing To Its Involvement In The Digestive Process Of Carbohydrate,Its Role In Intracellular Glycoprotein Trafficking,Tumorigenesis And Viral Infection. In This Study,Several Members Of A New Family Of N-Heteroarylmethyl Substituted Azasugars Were Synthesized And Evaluated As Alpha-Glucosidase Inhibitors. We Systematically Investigated The Effect Of Different N-Substituents As Well As The Role Of Hydroxyl And Carboxylate Moieties On The Piperidine Ring. The Compounds N-Heteroarylmethyl-5-Hydroxy-1,2,5,6-Tetrahydropyridine-3-Carboxylic Acid Emerged As Potent Alpha-Glucosidase Inhibitors. Unlike Acarbose And Other Clinically Relevant Alpha-Glucosidase Inhibitors,These Compounds Act Through A Reversible Uncompetitive Mechanism Of Inhibition Which Make Them Attractive Candidates For Drug Development. (C) 2013 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmc.2013.07.012