CAS: 5788-58-9; 4,5-Dibromopyridazin-3(2H)-One

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上下游产品

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Mucobromic Acid置于sodium Acetate,硫酸肼体系中,用 乙醇,水 作为反应溶剂,化学反应 5.0H,以90%的收率获得产物4,5-二溴哒嗪-3-酮
参考文献:轻松合成4,5-二取代-3(2 H)-哒嗪酮
标题:轻松合成4,5-二取代-3(2 H)-哒嗪酮
摘要:最初通过将醇钠加成到高级溴化物中间体中来合成4,5-二取代-3(2 H)-哒嗪酮.少量的平行化学反应会导致成功率降低,因此我们通过进行铜催化的finkelstein反应来提高反应伙伴的反应性.铜催化的各种醇与反应生成的碘化物的偶联导致更成功的努力.还描述了该系列化合物的许多替代合成,并且这些方法被证明是通用的,有效的并且适合于平行合成.
DOI:10.1016/j.Tetlet.2009.03.144

专利信息

专利号:WO-2021127273-A1
优先权日:2019-12-20
标题:1 -((6-oxo-1,6-dihydropyridazin-4-yl)methyl)piperazine and 1 -((6-oxo-1,6-dihydropyrimidin-4-yl)methyl)piperazine derivatives as prolyl hydroxylase, hif-1 alpha and pgk modulators for use in treating inflammatory diseases, cancer or infections
发明人：COBURN CRAIG; ROWBOTTOM MARTIN W
权利人:GB004 INC
摘要:Described herein are compounds of formulae (I), (lla) and (Mb) as prolyl hydroxylase inhibitors, HIF-lalpha stabilizers and PGK up regulators for use in treating inflammatory diseases, cancer or infections: Preferred compounds are e.g. tert-butyl-4-((l-benzyl-6-oxo-l,6- dihydropyridazin-4-yl)methyl)piperazine-l-carboxylate and tert-butyl-4-((l-benzyl-6-oxo-l,6-dihydropyrimidin-4-y I) methyl) piperazine-l-carboxylate derivatives and related compounds. Exemplary compounds are e.g. compound 1A: and compound 2A: The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 22 to 25 and 55 to 70; examples 1 to 5; compounds 1A to 2V; tables 1 and 2).