CAS: 556-02-5; D-Tyrosine

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556-03-6 60-18-4 1164-16-5

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L-酪氨酸置于l-Amino Acid Deaminase From Proteus Mirabilis,Burkholderia Stabilis Formate Dehydrogenase,Meso-Diaminopimelate Dehydrogenase From Symbiobacterium Thermophilum Mutant H227V,Sodium Formate,氯化铵,还原型辅酶ii(Nadph)四钠盐体系中,用 Aq. Phosphate Buffer 作为反应溶剂,化学反应生成 D-酪氨酸
参考文献:通过一锅生物催化立体转化级联从容易获得的 L-氨基酸中高选择性合成 D-氨基酸†
标题:通过一锅生物催化立体转化级联从容易获得的 L-氨基酸中高选择性合成 D-氨基酸†
摘要:D-氨基酸是重要药物合成所需的关键中间体.然而,建立一种通用的酶促方法,用于从廉价且易于获得的前体和很少的副产物中普遍合成d-氨基酸是具有挑战性的.在这项研究中,我们构建并优化了一条涉及l-氨基酸脱氨酶和d-氨基酸脱氢酶的级联酶催化途径,用于将l-氨基酸生物催化立体转化为d-氨基酸.使用l-苯丙氨酸 (L-Phe) 作为模型底物,这种人工生物催化级联立体反转路线首先将l-Phe 到苯丙酮酸 (Ppa) 通过涉及表达奇异变形杆菌(Pmlaad) 的l-氨基酸脱氨酶的重组大肠杆菌细胞的催化作用,然后用嗜热共生菌(Stdapdh)的重组内消旋二氨基庚二酸脱氢酶进行立体选择性还原胺化以产生d-苯丙氨酸(d-Phe).通过加入基于甲酸脱氢酶的 Nadph 循环系统,D-Phe 以定量产率获得,对映体过量大于 99%.此外,级联反应体系还用于立体转化多种芳香族和脂肪族l通过将 Pmlaad
DOI:10.1039/c9Ra06301C

专利信息

专利号:US-12421534-B2
优先权日:2021-11-10
标 题 :Engineered enzymes and method for the synthesis of diverse tyrosine analogs
发明人：ALMHJELL PATRICK J; ARNOLD FRANCES H
权利人:CALIFORNIA INST OF TECHN
摘要:Provided herein is an engineered tryptophan synthase β-subunit (TrpB) that catalyzes the synthesis of tyrosine, tyrosine analogs, or salts thereof. Also provided herein are methods for preparing tyrosine, tyrosine analogs, or a salt thereof using the engineered TrpB described herein.

专利号:US-9139515-B2
优先权日:2011-08-19
标 题:Synthesis of R-biphenylalaninol
发明人：HERMSEN PETRUS JOHANNES; ERMANN PETER HANS; RIEBEL PETER HANS; WOLBERG MICHAEL; DE VRIES ANDREAS HENDRIKUS MARIA
权利人:HERMSEN PETRUS JOHANNES; ERMANN PETER HANS; RIEBEL PETER HANS; WOLBERG MICHAEL; DE VRIES ANDREAS HENDRIKUS MARIA; DPX HOLDINGS BV
摘要:This invention relates to a novel process for the synthesis of R-biphenylalaninol and to intermediate compounds that are formed in the process according to the invention, i.e. novel intermediates useful in the synthesis of R-biphenylalaninol. The invention also relates to R-biphenylalaninol, The process according to the invention, the intermediates to of R-biphenylalaninol and of R-biphenylalaninol are all useful in the synthesis of pharmaceutically active compounds.

专利号:US-11753440-B2
优先权日:2018-06-05
标题 :Methods for the synthesis of arginine-containing peptides
发明人：HEIDL MARC; GEOTTI-BIANCHINI PIERO
权利人:DSM IP ASSETS BV
摘要:Methods for the synthesis of arginine-containing peptides are provided. The methods include a deprotection step that minimizes the transfer of by-products deriving from cleaved sulfonyl-5 based side chain protecting groups from arginine to amino acids carrying electron rich side chains.

专利号:US-12024731-B2
优先权日:2017-05-03
标 题 :Methods and enzyme catalysts for the synthesis of non-canonical amino acids
发明人：BOVILLE CHRISTINA E; BRINKMANN-CHEN SABINE; BULLER ANDREW R; ROMNEY DAVID K; PRIER CHRISTOPHER K; KOCH PHILIPP; SCHEELE REMKES A
权利人:CALIFORNIA INST OF TECHN
摘要:The present disclosure provides methods for preparing β-substituted tryptophan compounds. The methods include: combining i) an unsubstituted indole or a substituted indole, ii) a β-substituted serine, and iii) a tryptophan synthase β-subunit (i.e., a TrpB); and maintaining the resulting mixture under conditions sufficient to form the β-substituted tryptophan. The TrpB contains at least one amino acid mutation which promotes formation of an amino-acrylate intermediate. New TrpB variants and new β-substituted tryptophan analogs are also described.

专利号:US-10829792-B2
优先权日:2017-03-21
标 题 :Biocatalytic synthesis of strained carbocycles
发明人：CHEN KAI; HUANG XIONGYI; KAN S B JENNIFER
权利人:CALIFORNIA INST OF TECHN
摘要:Provided herein are methods for producing products containing strained carbocycles, such as cyclopropene moieties and/or bicyclobutane moieties. The methods include combining an alkyne and a carbene precursor in the presence of a heme protein, e.g., a cytochrome P450, under conditions sufficient to form the strained carbocycle. Reaction mixtures for producing strained carbocycles are also described, as well as whole-cell catalysts comprising heme proteins and variants thereof for forming cyclopropenes, bicyclobutanes, and related products.

专利号:US-2024218014-A1
优先权日:2022-11-21
标 题:Synthesis of a cyclic peptide
发明人：BAUR PIUS BRUNO; CLEATOR EDWARD; DENIAU GILDAS; EISELE FRANK; FLÖGEL OLIVER; HUSTE ANJA; KEHL MARCEL ROMAN; LÖWENECK MARKUS; SILVA ROLANDO RAVELO; VORBERG RAFFAEL
权利人:JANSSEN PHARMACEUTICA NV
摘要:Processes for performing peptide synthesis, particularly for cyclic peptide synthesis are generally described. Reaction intermediates of the peptide synthesis are also described.