CAS: 55557-52-3; 3-Chloropyrazine-2-Carbonitrile

相似化合物

21279-62-9 27398-39-6 121246-96-6

上下游产品

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3-吡嗪羧酰胺 1-氧化物置于四磷十氧化物,三氯氧磷体系中,用 Various Solvent(S) 作为反应溶剂,化学反应 0.92H,反应生成 2-氯-3-氰基吡嗪
参考文献:Sato,Nobuhiro,Journal Of Chemical Research,Miniprint,1984,# 10,P. 2860-2875
标题:Sato,Nobuhiro,Journal Of Chemical Research,Miniprint,1984,# 10,P. 2860-2875

专利信息

专利号:US-2024059678-A1
优先权日:2021-01-18
标 题 :Synthesis Method for Aminopyrimidine FAK Inhibitor Compound
发明人：DU WU; LV HAIBIN; LI YU; KUANG TONGTAO; GENG XI
权利人:HINOVA PHARMACEUTICALS INC
摘要:A synthesis method for an aminopyrimidine FAK inhibitor compound, relating to the field of pharmaceutical synthesis. In the synthesis method, R1 is hydrogen or a carboxylic acid protecting group, R2 is selected from C1ËœC6 alkyl or C1ËœC6 deuterated alkyl, R3 and R4 are each independently selected from hydrogen or deuterium, and R5 is selected from C1ËœC6 alkyl or C1ËœC6 deuterated alkyl. The synthesis method is simple to operate, and has low costs. The product prepared can obtain a high total yield (≥66%) and a high purity (≥99%), and the product yield and purity are superior to those in the prior art (in the prior art, the total yield is about 11%, and the purity is 99%). The synthesis method achieves excellent effects, can also successfully prepare a final product on kilogram scale, and is suitable for industrial production, having a good application prospect.

专利号:CN-109182286-A
优先权日:2018-09-21
标题:An improved cyano reductase and its application in the synthesis of 3-chloropyrazine-2 methylamine

专利号:CN-109182286-B
优先权日:2018-09-21
标 题:Improved cyano reductase and application thereof in synthesis of 3-chloropyrazine-2 methylamine

专利号:SU-1738088-A3
优先权日:1987-07-17
标 题 :Method for synthesis of cis-derivatives of n-(3-hydroxy-4-piperidinyl)-benzamide

专利号:CN-108250186-B
优先权日:2018-02-07
标 题 :Synthesis method of Acaraburtinib and intermediate thereof

专利号:CN-118772144-A
优先权日:2024-05-17
标题:Synthesis method of pyrido [3,4-b ] pyrazine-5-amine compound