CAS: 55289-06-0; 3-Methoxy-2-Methylbenzoic Acid

上下游产品

CAS号603-80-5 3-羟基-2-甲基苯甲酸 | CAS号77-78-1 硫酸二甲酯 | CAS号10533-44-5 1,2,3,5-三磺酸萘三钠 | CAS号42981-93-1 3-甲氧基-2-甲基苯甲酸甲酯 | CAS号7499-08-3 3-氯-2-甲基苯甲酸 | CAS号586-38-9 3-甲氧基苯甲酸 | CAS号74-88-4 碘甲烷 | CAS号52130-17-3 2-甲基-3-氨基苯甲酸 | CAS号72623-17-7 2-(3-methoxy-2-... | CAS号131-27-1 2-萘胺-4,8-二磺酸 | CAS号366453-22-7 4-甲氧基异吲哚啉-1-酮 | CAS号42981-93-1 3-甲氧基-2-甲基苯甲酸甲酯 | CAS号24487-91-0 3-甲氧基-2-甲基苯甲酰氯 | CAS号55289-17-3 6-溴-3-甲氧基-2-甲基苯甲酸 | CAS号603-80-5 3-羟基-2-甲基苯甲酸 | CAS号71887-28-0 2-溴甲基-3-甲氧基苯甲酸甲酯 | CAS号33797-34-1 (3-甲氧基-2-甲基苯基)甲醇 | CAS号164082-77-3 (3-METHOXY-2-ME... | CAS号161050-58-4 甲氧虫酰肼 | CAS号14963-97-4 3-甲氧基苯-1,2-二甲酸

2-甲基-3-硝基苯甲酸置于硫酸,Palladium On Activated Charcoal,水,氢气,Sodium Hydroxide,Sodium Nitrite体系中,用 甲醇,水 作为反应溶剂,40.0~100.0 °C,500.01 Kpa 条件下,反应 15.5H,反应生成 3-甲氧基-2-甲基苯甲酸
参考文献:一种2-甲基-3-甲氧基苯甲酰氯的合成工艺
标题:一种2-甲基-3-甲氧基苯甲酰氯的合成工艺
摘要:本发明公开了一种2‑甲基‑3‑甲氧基苯甲酰氯的合成工艺,采用低廉的邻二甲苯为起始原料,通过常规合成方法硝化,酯化,还原,重氮化,甲基化,酰氯化等步骤合成得到产品,总收率控制在65%以上.中间产物酯化步骤提高了中间体可分离程度;重氮步骤加入了反应溶剂,工艺参数较易控制,本步骤中间体纯度在96%以上,为后续产品品质提供了保障,产品品质稳定可靠,成本低廉.

专利信息

专利号:WO-2022222272-A1
优先权日:2021-04-19
标 题 :Synthesis process of 2-methyl-3-methoxybenzoic acid
发明人：GENG JINGKUN; Fang Zheneng; YAO LINXI; JI PINJUN; ZHANG YANCHAO; MIAO JUNHUI; WANG BOTAO
权利人:JIANGSU YONGAN CHEMICAL CO LTD
摘要:Disclosed is a synthesis process of 2-methyl-3-methoxybenzoic acid. The synthesis process comprises the following steps: (1) a reductive hydrogenation reaction, involving: using 2-methyl-3-nitrobenzoic acid or methyl 2-methyl-3-nitrobenzoate as a raw material, methanol as a solvent, hydrogen as a hydrogen source and palladium on carbon or platinum on carbon as a catalyst to prepare 3-amino-2-methylbenzoic acid or methyl 3-amino-2-methylbenzoate by means of hydrogenation reduction; (2) a one-pot reaction of diazotization, hydrolysis and esterification, involving: using the reduction product as a raw material and methanol as a solvent to prepare methyl 3-hydroxy-2-methylbenzoate by means of diazotization, hydrolysis and esterification reactions under the action of a diazotization reagent; (3) a methylation reaction, involving: using methyl 3-hydroxy-2-methylbenzoate as a raw material and dimethyl sulfate as a methylation reagent to prepare methyl 3-methoxy-2-methylbenzoate by means of a methylation reaction in the presence of an alkali; and (4) a hydrolysis reaction, involving: mixing methyl 3-methoxy-2-methylbenzoate with an alkali and water, and heating same for hydrolysis, cooling same after the reaction is completed, adjusting the pH to 1-3 with an acid to precipitate a product, followed by filtering and drying same to obtain 3-methoxy-2-methylbenzoic acid.

专利号:US-2012115907-A1
优先权日:2009-04-24
标题 :Novel compounds as inhibitors of renin
发明人：THOMBARE PRAVAIN; DESAI JIGAR; JAIN MUKUL R
权利人:THOMBARE PRAVAIN; DESAI JIGAR; JAIN MUKUL R; CADILA HEALTHCARE LTD
摘要:The present invention relates to novel renin inhibitors of general formula (1), novel intermediates involved in their synthesis, their pharmaceutically acceptable salts and pharmaceutical compositions containing them. The present invention also relates to a process of preparing compounds of general formula (1), their tautomeric forms, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and novel intermediates involved in their synthesis.

专利号:US-5846993-A
优先权日:1992-12-22
标题:HIV protease inhibitors
发明人：DRESSMAN BRUCE A; FRITZ JAMES E; KALDOR STEPHEN W; KALISH VINCENT J; REICH SIEGFRIED HEINZ; TATLOCK JOHN H; RODRIGUEZ MICHAEL J
权利人:AGOURON PHARMA
摘要:HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optionally other anti-viral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS.

专利号:WO-9314086-A1
优先权日:1992-01-17
标 题 :Substituted 1-isoquinolone derivatives as angiotensin ii antagonists
发明人：FISHER LAWRENCE E; CAROON JOAN M; STABLER STEPHEN R; CLARK ROBIN D
权利人:SYNTEX INC
摘要:1-Isoquinolone derivatives and related compounds according to formula (I) wherein, Y is selected from the group consisting of H, OH, lower alkoxy, and halo; X is selected from the group consisting of H, lower alkyl acid, lower alkyl ester, and lower alkyl; and R1 is selected from the group consisting of H, alkenyl, lower alkyl, lower cycloalkyl, unsubstituted or substituted 3-spiro-1H-indane of structure (II) wherein R2 is H, OH, lower alkyl, lower alkoxy or halo, and 3-spiro-cycloalkyl of structure (III) wherein n is an integer from zero to six, provided that when R1 is spiro- X is H, or a pharmaceutically acceptable salt thereof, with the proviso that when R1 is spiro-, X is H, and when R1 is H, alkenyl, lower alkyl or lower cycloalkyl substituted at the 3-position of the isoquinolone moiety and X is H or lower alkyl, the (2'-1H--tetrazol-5-yl)biphenyl-4'-ylmethyl group cannot be at the 2(N) position, are useful as angiotensin II receptor antagonists. Also disclosed are methods of synthesis, intermediates, pharmaceutical formulations and methods of treatment.

专利号:US-8178559-B2
优先权日:2004-12-30
标 题:Organic compounds
发明人：BREITENSTEIN WERNER; EHARA TAKERU; EHRHARDT CLAUS; GROSCHE PHILIPP; HITOMI YUKO; IWAKI YUKI; KANAZAWA TAKANORI; KONISHI KAZUHIDE; MAIBAUM JUERGEN KLAUS; MASUYA KEIICHI; IWASAKI ATSUKO; OSTERMANN NILS; SUZUKI MASAKI; TOYAO ATSUSHI; YOKOKAWA FUMIAKI
权利人:BREITENSTEIN WERNER; EHARA TAKERU; EHRHARDT CLAUS; GROSCHE PHILIPP; HITOMI YUKO; IWAKI YUKI; KANAZAWA TAKANORI; KONISHI KAZUHIDE; MAIBAUM JUERGEN KLAUS; MASUYA KEIICHI; IWASAKI ATSUKO; OSTERMANN NILS; SUZUKI MASAKI; TOYAO ATSUSHI; YOKOKAWA FUMIAKI; NOVARTIS AG
摘要:3,4-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,4-substituted piperidine compound, and/or a method of treatment comprising administering a 3,4substituted piperidine compound, a method for the manufacture of a 3,4-substituted piperidine compound, and novel intermediates and partial steps for their synthesis are disclosed. The 3,4-disubstituted piperidine compounds have the formula (I), wherein the symbols have the meanings defined in the specification.

专利号:CN-113248351-B
优先权日:2021-05-26
标 题 :Preparation method of 6-chloro-2-methoxytoluene and synthesis technology of methoxyfenozide