CAS: 526-84-1; 2,3-Dihydroxymaleic Acid

相似化合物

13096-38-3 133-47-1 2215-12-5

上下游产品

CAS号87-69-4 酒石酸 | CAS号7732-18-5 水 | CAS号10035-10-6 氢溴酸 | CAS号64-19-7 冰醋酸 | CAS号7580-59-8 2,3-二氧代琥珀酸 | CAS号473-90-5 中草酸 | CAS号76-30-2 二羟基酒石酸 | CAS号141-46-8 羟乙醛 | CAS号75640-08-3 Propanoicacid, ... | CAS号7580-59-8 2,3-二氧代琥珀酸 | CAS号815-53-2 2,3-dioxopropan...

📜Dioxo-Succinic Acid ; Potassium Compound,Alkaline Earth Salt Of/the/ Methylsulfuric Acid 反应生成 二羟基顺丁烯二酸
参考文献:Fenton,Journal Of The Chemical Society,1898,Vol. 73,P. 480
标题:Fenton,Journal Of The Chemical Society,1898,Vol. 73,P. 480

专利信息

专利号:WO-0200681-A1
优先权日:2000-06-27
标题 :20-fluoro-17(20)-vinyl steroids as inhibitors of c17-20-lyase and 5-alpha reductase
发明人：PEET NORTON P; WEINTRAUB PHILIP M; BURKHART JOSEPH P; GATES CYNTHIA A
权利人:AVENTIS PHARMA INC; PEET NORTON P; WEINTRAUB PHILIP M; BURKHART JOSEPH P; GATES CYNTHIA A
摘要:The invention related to 20κ-fluoropregna-4,17(20)-dien-3-on-21-oic acid ethyl ester, 20κ-fluoro-3β-hydroxypregna-4,17(20)-dien-21-oic acid ethyl ester, 20κ-fluoro-21-hydroxypregna-4,17(20)-dien-3-one, 20κ-fluoropregna-4,17(20)-dien-3β,21-diol and related compounds and to compositions incorporating these compounds, as well as the inhibition of C17,20 lyase, 5α-reductase and C17-hydroxylase, and to the use of these compounds in the treatment of androgen and estrogen mediated or dependent disorders, including benign prostatic hyperplasia, prostate cancer, breast cancer and DHT-mediated disorders such as acne and hirsutism. Treatment of disorders related to the over synthesis of cortisol, for example, Cushing's Syndrome are also included. The treatment of androgen-dependent disorders also includes a combination therapy with known androgen-receptor antagonists, such as flutamide. The compounds of the invention have general formulae (I).

专利号:US-4107210-A
优先权日:1976-09-07
标 题 :Synthesis of alpha-diketones
发明人：FREITER EDWARD R
权利人:DOW CHEMICAL CO
摘要:Alpha-diketones, such as 1-phenyl-1,2-propanedione and 1-propyl-1,2-butanedione, are prepared by reacting an acylmethyl ester of a carboxylic acid (e.g., benzoylmethyl acetate or butanoylmethyl propionate) with an aldehyde, such as formaldehyde or acetaldehyde, in the presence of an acid catalyst and water. Such alpha-diketones are also obtained by first refluxing a mixture of an alpha-haloketone and a carboxyl anion source and then reacting the mixture with an aldehyde in the presence of an acid catalyst and water.

专利号:US-6413951-B2
优先权日:2000-06-27
标题:20-fluoro-17(20)-vinyl steroids
发明人：PEET NORTON P; WEINTRAUB PHILIP M; BURKHART JOSEPH P; GATES CYNTHIA A
权利人:AVENTIS PHARMA INC
摘要:The invention relates to 20ξ-fluoropregna-4,17(20)-dien-3-on-21-oic acid ethyl ester, 20ξ-fluoro-3beta-hydroxypregna-5,17(20)-dien-21-oic acid ethyl ester, 20ξ-fluoro-21-hydroxypregna-4,17 (20)-dien-3-one, 20ξ-fluoropregna-5,17(20)-dien-3beta,21-diol and related compounds and to compositions incorporating these compounds, as well as the inhibition of C17,20 lyase, 5alpha-reductase and C17-hydroxylase, and to the use of these compounds in the treatment of androgen and estrogen mediated or dependent disorders, including benign prostatic hyperplasia, prostate cancer, breast cancer and DHT-mediated disorders such as acne and hirsutism. Treatment of disorders related to the over synthesis of cortisol, for example, Cushing's Syndrome are also included. The treatment of androgen-dependent disorders also includes a combination therapy with known androgen-receptor antagonists, such as flutamide. The compounds of the invention have the following general formulae:

专利号:US-3948876-A
优先权日:1973-12-14
标 题 :Process for the purification of synthetic calcitonins
发明人：RITTEL WERNER; BRUGGER MAX; RINIKER BERNHARD
权利人:CIBA GEIGY CORP
摘要:Peptides of the calcitonin type when obtained by synthesis can be purified in a simple manner by forming inner salts, which precipitate from aqueous solutions of salts of the peptides with acids or bases when these solutions are adjusted to the isoelectric range. Impurities remain in solution, while the inner salts separate practically quantitatively. The precipitation is completed after several hours. The peptides can then be recuperated by treatment with an acid, especially a therapeutically suitable acid. The process affords products which are superior to those obtained by purification methods hitherto known and gives higher yields. Other long-chain peptides such as ACTH, insulin or glucagon cannot be purified in this manner.

专利号:EP-0723958-A1
优先权日:1993-06-24
标 题:Synthesis of substantially pure terfenadine derivatives