CAS: 52031-05-7; Ethyl 2-Amino-3-(4-Chlorophenyl)Propanoate Hydrochloride

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CAS号64-17-5 乙醇 | CAS号23633-07-0 2-amino-3-(4-ch... | CAS号6941-36-2 Propanedioic ac... | CAS号69555-14-2 二苯亚甲基甘氨酸乙酯 | CAS号104-83-6 4-氯氯苄 | CAS号7424-00-2 DL-4-氯苯基丙氨酸 | CAS号104-88-1 对氯苯甲醛 | CAS号84713-70-2 (4-chlorobenzyl... | CAS号622-95-7 4-氯溴苄 | CAS号7424-00-2 DL-4-氯苯基丙氨酸 | CAS号14173-39-8 4-氯-L-苯基丙氨酸 | CAS号166449-97-4 (R)-B-(P-CHLORO...

📜2-Acetylamino-2-(4-Chlorobenzyl)Malonic Acid Diethyl Ester置于盐酸体系中,用 1,4-二氧六环,水 作为反应溶剂,化学反应生成 Dl-4-氯苯丙氨酸乙酯盐酸盐
参考文献:Anthranilic Acid Based Cck1 Receptor Antagonists: Preliminary Investigation On Their Second "touch Point"
标题:Anthranilic Acid Based Cck1 Receptor Antagonists: Preliminary Investigation On Their Second "touch Point"
摘要:In This Phase Of Structure-Affinity Relationship Study Of Vl-0395,A New Anthranilic Acid Based Cck1 Selective Antagonist,We Propose A Series Of Unnatural Aminoacidic Derivatives. The Result Of This Work Is The Identification Of A New Cck Ligand,Which Possesses An Affinity (Ic50 = 35 Nm) One Order Of Magnitude Greater Than The Lead And,As A General Rule,It Points Out How The Hypothesized Receptorial Pocket Which Accommodates The Phe Residue Allows Much More Structural Modification Than That Interacting With The N-Terminal Group. Hence,The Modification Of The C-Terminal Pharmacophoric Group Of Our Lead Vl-0395 Can Not Only Enhance The Affinity Of Anthranific Acid Derivatives But Can Modulate The Selectivity For One Cck Receptor Subtype Or Afford Mixed Antagonists. (C) 2005 Elsevier Sas. All Rights Reserved.
DOI:10.1016/j.Ejmech.2005.01.002

专利信息

专利号:US-5552421-A
优先权日:1991-09-24
标 题:Leukotriene biosynthesis inhibitors
发明人：LAZER EDWARD S; ADAMS JULIAN; MIAO CLARA K; FARINA PETER
权利人:BOEHRINGER INGELHEIM PHARMA
摘要:Various substituted benzoxazoles and benzothiazoles, are described and disclosed, which are potent inhibitors of leukotriene synthesis in warm-blooded animals.