CAS: 478-73-9; (+/-)-Pseudococaine

专利信息

专利号:US-12291527-B2
优先权日:2017-07-25
标 题 :Molecules that stimulate the immune system for treatment of drug addiction, methods of synthesis, antidrug vaccine and uses
发明人：DE FATIMA ANGELO; DUARTE GARCIA FREDERICO; ANTUNES FERNANDES SIMONE ODILIA; NASCIMENTO CARDOSO VALBERT; MARTINS GODIN ADRIANA; FALEIROS DA SILVA MAIA ANGELICA; DA SILVA NETO LEONARDO; DE CASTRO LOURENCO DAS NEVE MAILA; DE ALMEIDA AUGUSTO PAULO SERGIO
权利人:UNIV MINAS GERAIS; FUND DE AMPARO A PESQUISA DO ESTADO DE MINAS GERAIS—FAPEMIG
摘要:This technology relates to immune system stimulating molecules to be used in the treatment of drug addiction and abuse and their synthesis processes. These molecules have a calixarene chemical structure, preferably calix[4]arene and/or calix[8]arene, coupled to an hapten analogous to cocaine, preferably GNE and/or GNC. An anti-drug vaccine, specifically anti-cocaine, is also described using such molecules. The anti-drug vaccine can be also used to prevent fetal exposure to drugs in pregnant women who use drugs and do not wish or cannot stop their use during pregnancy.

专利号:US-7993390-B2
优先权日:2002-02-08
标 题:Implantable or insertable medical device resistant to microbial growth and biofilm formation
发明人：MILLER KATHLEEN M; BUCAY-COUTO WEENNA; LI JIANMIN
权利人:BOSTON SCIENT SCIMED INC
摘要:Disclosed are implantable or insertable medical devices that provide resistance to microbial growth on and in the environment of the device and resistance to microbial adhesion and biofilm formation on the device. In particular, the invention discloses implantable or insertable medical devices that comprise at least one biocompatible matrix polymer region, an antimicrobial agent for providing resistance to microbial growth and/or a microbial adhesion/biofilm synthesis inhibitor for inhibiting the attachment of microbes and the synthesis and accumulation of biofilm on the surface of the medical device. Also disclosed are methods of manufacturing such devices under conditions that substantially prevent preferential partitioning of any of said bioactive agents to a surface of the biocompatible matrix polymer and substantially prevent chemical modification of said bioactive agents.

专利号:WO-2019021140-A1
优先权日:2017-07-25
标题 :STIMULATORY MOLECULES OF THE IMMUNOLOGICAL SYSTEM FOR TREATMENT OF ABUSE DRUG DEPENDENCE, SYNTHESIS PROCESSES, ANTI-DRUG VACCINE AND USES

专利号:US-2020385376-A1
优先权日:2017-07-25
标题 :Molecules that stimulate the immune system for treatment of drug addiction, methods of synthesis, antidrug vaccine and uses