CAS: 4773-96-0; 1,3,6,7-Tetrahydroxy-2-((2S,3R,4R,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)-9H-Xanthen-9-One

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CAS号1239694-50-8 2-C-(2,3,4,6-te... | CAS号2054-37-7 (1,6,7-triacety... | CAS号3542-72-1 芒果苷元

1,6,7-Trihydroxy-2-C-(2,3,4,6-Tetra-O-Benzyl-β-D-Glucopyranosyl)-3-O-Benzylxanthone置于10% Palladium Hydroxide On Charcoal,氢气体系中,用 甲醇 作为反应溶剂,20.0 °C,101.33 Kpa 条件下,反应 48.0H,以90%的收率获得产物芒果苷
参考文献:芒果苷,同型芒果苷和新芒果苷的总合成†
标题:芒果苷,同型芒果苷和新芒果苷的总合成†
摘要:从2,3,4,6-四-O-苄基-α/β-D-起始已实现了芒果苷,高芒果苷和新芒果苷的全合成,这是三种具有广泛药理作用的c-糖基yl吨酮天然产物.吡喃葡萄糖.关键步骤包括用四苄基吡喃葡萄糖基乙酸酯立体选择性的路易斯酸促进受保护的间苯三酚的c-糖基化和高度区域选择性的碱基诱导的环化,以构建核心黄酮骨架.
DOI:10.1039/c6Ob01622G

专利信息

专利号:US-10768157-B2
优先权日:2015-10-20
标 题:Materials and methods for the detection of trace amounts of substances in biological and environmental samples
发明人：KABIR ABUZAR; FURTON KENNETH G
权利人:KABIR ABUZAR; FURTON KENNETH G; THE FLORIDA INTERNATIONAL UNIV BOARD OF TRUSTEES
摘要:The subject invention provides chemical compositions and synthesis strategies to create molecularly imprinted polymers (MIPs) via sol-gel processes. In a specific embodiment, the subject invention utilizes a(n) organic, inorganic, or metallic template analyte to create a hybrid organic-inorganic or inorganic three-dimensional network possessing cavities complementary to the shape, size, and functional orientation of the template molecule or ions. The subject invention further pertains to the use of the novel MIPs as selective solid phase extraction (SPE) sorbents for pre-concentration and clean-up of trace substances in biological and environmental samples. Synthesis of other molecularly imprinted polymers with environmental, pharmaceutical, chemical, clinical, toxicological, and national security implications can be conducted in accordance with the teachings of the subject invention.

专利号:US-2006078533-A1
优先权日:2004-10-12
标 题:Method of prevention and treatment of aging and age-related disorders including atherosclerosis, peripheral vascular disease, coronary artery disease, osteoporosis, arthritis, type 2 diabetes, dementia, alzheimer's disease and cancer
发明人：OMOIGUI OSEMWOTA S
权利人:OMOIGUI OSEMWOTA S
摘要:This invention relates to a method for prevention and treatment of aging and age-related disorders including atherosclerosis, peripheral vascular disease, coronary artery disease, osteoporosis, type 2 diabetes, dementia and some forms of arthritis and cancer in a subject comprising administering to said subject, separately, sequentially or simultaneously a therapeutically effective dosage of each component or combination of statins, bisphosphonates, cholesterol lowering agents or techniques, interleukin-6 inhibitor/antibody, interleukin-6 receptor inhibitor/antibody, interleukin-6 antisense oligonucleotide (ASON), gp130 protein inhibitor/antibody, tyrosine kinases inhibitors/antibodies, serine/threonine kinases inhibitors/antibodies, mitogen-activated protein (MAP) kinase inhibitors/antibodies, phosphatidylinositol 3-kinase (PI3K) inhibitors/antibodies, Nuclear factor κB (NF-κB) inhibitors/antibodies, IκB kinase (IKK) inhibitors/antibodies, activator protein-1 (AP-1) inhibitors/antibodies, STAT transcription factors inhibitors/antibodies, altered IL-6, partial peptides of IL-6 or IL-6 receptor, or SOCS (suppressors of cytokine signaling) protein, or a functional fragment thereof, administered separately, in sequence or simultaneously. Inhibition of the signal transduction pathway for Interleukin 6 mediated inflammation is key to the prevention and treatment of atherosclerosis, peripheral vascular disease, coronary artery disease, aging and age-related disorders including osteoporosis, type 2 diabetes, dementia and some forms of arthritis and tumors. Inhibition of Interleukin 6 mediated inflammation may be achieved indirectly through regulation of endogenous cholesterol synthesis and isoprenoid depletion or by direct inhibition of the signal transduction pathway utilizing interleukin-6 inhibitor/antibody, interleukin-6 receptor inhibitor/antibody, interleukin-6 antisense oligonucleotide (ASON), gp130 protein inhibitor/antibody, tyrosine kinases inhibitors/antibodies, serine/threonine kinases inhibitors/antibodies, mitogen-activated protein (MAP) kinase inhibitors/antibodies, phosphatidylinositol 3-kinase (PI3K) inhibitors/antibodies, Nuclear factor κB (NF-κB) inhibitors/antibodies, IκB kinase (IKK) inhibitors/antibodies, activator protein-1 (AP-1) inhibitors/antibodies, STAT transcription factors inhibitors/antibodies, altered IL-6, partial peptides of IL-6 or IL-6 receptor, or SOCS (suppressors of cytokine signaling) protein, or a functional fragment thereof. Said method for prevention and treatment of said disorders is based on inhibition of Interleukin-6 inflammation through regulation of cholesterol metabolism, isoprenoid depletion and/or inhibition of the signal transduction pathway.

专利号:CN-104447818-A
优先权日:2014-10-23
标题:Synthesis of a mangiferin-zinc complex and its anti-inflammatory and antitussive effects

专利号:CN-112779235-A
优先权日:2021-01-14
标 题:A method for biocatalytic synthesis of multiple flavonoid glycosides

专利号:FR-2882762-A1
优先权日:2005-03-04
标 题 :SYNTHESIS OF A MANGIFERIN SUGAR DERIVATIVE

专利号:CN-114751442-B
优先权日:2022-03-08
标 题 :An ultrasound-assisted method for green synthesis of nano-zinc oxide from coffee leaf extract