CAS: 4376-18-5; 2-(Methoxycarbonyl)Benzoic Acid

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CAS号131-11-3 邻苯二甲酸二甲酯； 避蚊酯 | CAS号124-38-9 二氧化碳 | CAS号610-97-9 邻碘苯甲酸甲酯 | CAS号73513-53-8 phthalic acid 1... | CAS号1225-85-0 Benzyl methyl p... | CAS号67-56-1 甲醇 | CAS号85-44-9 苯酐 | CAS号4122-56-9 2-醛基苯甲酸甲酯 | CAS号124-41-4 甲醇钠 | CAS号78657-44-0 (Z)-1-morpholin... | CAS号33744-74-0 (-)-单-(1R)-薄荷基邻苯二甲酸酯 | CAS号85-44-9 苯酐 | CAS号431-47-0 三氟乙酸甲酯(TFAM) | CAS号88-99-3 邻苯二甲酸 | CAS号90564-02-6 2-氨基甲酰基苯甲酸甲酯 | CAS号4122-56-9 2-醛基苯甲酸甲酯 | CAS号438470-19-0 2-[(琥珀酰亚胺氧基)羰基]苯甲酸甲酯 | CAS号5123-55-7 N-邻苯二甲酰-L-苯丙氨酸 | CAS号18435-67-1 imino-[2-(2-met... | CAS号520-03-6 N-苯基邻苯二甲酰亚胺

📜邻苯二甲酸二甲酯置于potassium Hydroxide体系中,用 水,二甲基亚砜 作为反应溶剂,化学反应 0.67H,以94%的收率获得产物邻苯二甲酸单甲酯
参考文献:实用的大体积对称二酯选择性单水解
标题:实用的大体积对称二酯选择性单水解
摘要:我们先前报道的高效选择性单水解反应已应用于几种大体积对称双酯的单水解反应,包括二乙酯,二丙酯和二丁酯.与相应的二甲基酯相比,更大比例的极性非质子助溶剂,Dmso和koh水溶液似乎有助于改善大体积二酯的反应性.该过程是温和且实用的,在简单条件下以高收率得到相应的半酯.
DOI:10.1016/j.Tetlet.2017.12.061

专利信息

专利号:US-2006287520-A1
优先权日:2005-05-16
标 题 :Synthesis of salinosporamide A and analogues thereof
发明人：DANISHEFSKY SAMUEL J; ENDO ATSUSHI
权利人:DANISHEFSKY SAMUEL J; ENDO ATSUSHI
摘要:A novel synthesis of salinosporamide A is provided. Salinospoamide A as well as structurally related natural products, omuralide and lactacystin, have been shown to be proteasome inhibitors. Therefore, these compounds as well as analogues of these natural products may be useful in the treatment of proliferative diseases such as cancer, autoimmune diseases, diabetic retinopathy, etc. The invention provides for the synthesis of salinosporamide A as well as analogs thereof using a convenient point for derivatization of the bicyclic core. Pharmaceutical compositions and method of using the inventive compounds are also provided.

专利号:US-7910623-B2
优先权日:2005-07-22
标 题 :Synthesis of scabronines and analogues thereof
发明人：DANISHEFSKY SAMUEL J; WATERS STEPHEN P
权利人:SLOAN KETTERING INST CANCER
摘要:A novel synthesis of scabronines, which are related to a broader class of angularly fused tricyclic diterpenoids known as cyathanes, is provided. Scabronine G, its methyl ester derivative, and other analogs have been shown to have neurotrophic activity. Therefore, these compounds are particularly useful in treating neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's diseases, etc. The invention provides for the synthesis of scabronines as well as analogs thereof. Pharmaceutical compositions and method of using the inventive compounds are also provided.

专利号:WO-2012047907-A9
优先权日:2010-10-04
标题 :Synthesis of c5-substituted tetracyclines, uses thereof, and intermediates thereto
发明人：MYERS ANDREW G; WRIGHT PETER M; HECKER EVAN
权利人:HARVARD COLLEGE; MYERS ANDREW G; WRIGHT PETER M; HECKER EVAN
摘要:The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The recent development of a modular synthesis of tetracycline analogs through a chiral enone intermediate has allowed for the efficient synthesis of novel tetracycline analogs never prepared before. The present invention provides more efficient routes for preparing the enone intermediate and allows for a wide variety of substituents at position 5 of the tetracycline ring system.

专利号:US-6376667-B1
优先权日:1997-11-26
标 题 :Solid phase synthesis of heterocycles
发明人：CASTELHANO ARLINDO L; SHAO HUI
权利人:OSI PHARM INC
摘要:Methods and compounds for the synthesis of heterocycles, including pyrimidine-2,4-diones, are disclosed. Also disclosed are solid supports useful for solid phase synthesis, and methods for making the solid supports.

专利号:US-9688644-B2
优先权日:2009-04-30
标 题 :Synthesis of Tetracyclines and intermediates thereto
发明人：MYERS ANDREW G; KUMMER DAVID A; LI DERUN; HECKER EVAN; DION AMELIE; WRIGHT PETER M
权利人:HARVARD COLLEGE
摘要:The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The recent development of a modular synthesis of tetracycline analogs through a chiral enone intermediate has allowed for the efficient synthesis of novel tetracycline analogs never prepared before. The present invention provides more efficient routes for preparing the enone intermediate and allows for substituents at positions 4a, 5, 5a, and 12a of the tetracycline ring system.

专利号:US-11999757-B2
优先权日:2017-11-01
标 题:Synthesis of boronate ester derivatives and uses thereof
发明人：BOYER SERGE HENRI; HECKER SCOTT J; VERZIJL GERARDUS K M; HERMSEN PETRUS J
权利人:MELINTA SUBSIDIARY CORP
摘要:Disclosed herein are methods for the preparation of boronate derivatives in the synthesis of antimicrobial compounds and uses thereof. Disclosed herein includes method of making a compound of Formula (B) by reducing the ketone group of the keto-ester compound of Formula (A), and the reduction can be performed using a Ruthenium based catalyst system or using an alcohol dehydrogenase bioreduction system.