CAS: 37831-70-2; Phaseollidin

该化合物是一种复杂的有机化合物,具有独特的多环结构,具有一种复合有机化合物[32-c][1]Benzopyran核心,表明其潜在的生物活动;氢氧基组在3和9个位置的存在有助于其溶性与再活动,而处于10位的3-甲基-2-丁-1-yl的替代成分可能会影响其与生物目标的互动.以(6aR,11a)配置为注解的立体化学学提出了可能影响化合物药理特性的具体空间安排.这些化合物经常被研究其潜在的治疗效果,包括抗氧化和防氟性活动.

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Phaseollidin Hydrate

合成工艺路线路线简述

    📜Phaseollidin Hydrate 反应生成 水,菜豆素
    参考文献:茄镰刀菌(fusarium Solani F.)sp.催化异黄酮类植物抗毒素,菜豆蛋白水合的菜豆油.
    标题:茄镰刀菌(fusarium Solani F.)sp.催化异黄酮类植物抗毒素,菜豆蛋白水合的菜豆油.
    摘要:菜豆(法国菜豆)产生的抗菌素植物抗毒素中有异戊烯基异黄酮酮和菜豆素.大豆病原菌镰刀菌(fusarium Solani F.)的培养滤液中出现两种酶活性,分别为基维酮水合酶和菜豆蛋白水合酶.sp.菜豆素,并催化植物抗毒素的二甲基烯丙基部分发生类似的水合反应.在羟基磷灰石层析和随后的制备性天然凝胶电泳过程中,酶几乎被共纯化.测定来自天然凝胶的连续切片的洗脱液的两种活性.尽管它们没有在天然凝胶中完全分离,但活性谱表明这两种活性是不同的.菜豆蛋白的菜豆蛋白水合酶的km约为7 Microm.
    DOI:10.1016/0378-1097(92)90606-O

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    专利信息


    专利号:US-7763292-B2
    优先权日:2004-05-10
    标题 :Cancer cell growth inhibition by black bean (Phaseolus vulgaris L) extracts
    发明人:GUTIERREZ-URIBE JANET A; SERNA-SALDIVAR SERGIO R O; MORENO-CUEVAS JORGE E; HERNANDEZ-BRENES CARMEN; GUAJARDO-TOUCHE ELSA M
    权利人:INST TECHNOLOGICO Y DE ESTUDIO
    摘要:This invention relates to processes or methods for the production of compositions comprising extracts of black beans containing phenolics, such as polyphenols, flavonoids, and tannins, phytosterols, and triterpenoids such as saponins and other natural products with proven antioxidant capacity, colorant capacity, and uses thereof, e.g., as antioxidants, nutritional supplements, as food, cosmetic or pharmaceutical antioxidants or colorants, as antineoplastic or anti-cancer or anti-tumor preparations, e.g., to treat, prevent and/or inhibit cancers or cancer cell growth, such as hormone dependent or hormone independent tumors or cancers or cancer cells. such as mammalian mammary, prostate, colon, hepatic, leukemia cancer or cancer cell growth, as active ingredient(s) in compositions for lowering cholesterol or lowering oxidation of LDL or for inhibiting cholesterol synthesis (or the enzyme therefor), as an active ingredient(s) in compositions, e.g., nutritional supplements.

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    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Turbek CS, Smith DA, Schardl CL. An extracellular enzyme from Fusarium solani f. sp. phaseoli which catalyses hydration of the isoflavonoid phytoalexin, phaseollidin. FEMS Microbiol Lett. 1992 Jul 1;73(1-2):187-90. doi: 10.1055/s-0031-1298310. Epub 2012 Feb 21. Erratum in: Planta Med. 2012 May;78(7):E20. Chinese.

    合成参考文献


    摘要:Resch, V.; Hanefeld, U., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 2, 271.
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