2-羟基-5-硝基吡啶置于喹啉,盐酸,Potassium Chlorate,三氯氧磷体系中,化学反应 2.25H,反应生成5-硝基-2,3-二氯吡啶 参考文献:Chemistry Of 3-Hydroxypyridine Part 2: Synthesis Of 5,6-Dihalo-3-Hydroxypyridines 标题:Chemistry Of 3-Hydroxypyridine Part 2: Synthesis Of 5,6-Dihalo-3-Hydroxypyridines 摘要:本文介绍了从市售的 2-Hydroxy-5-Nitropyridine 开始,多步骤合成迄今未知的 5,6-二卤-3-羟基吡啶的方法.此外,还探讨了廉价的 2-氨基甲基呋喃(糠胺)在新颖的两步法中制备标题化合物的适用性. Doi:10.1055/s-1990-26919
专利号:US-4756739-A 优先权日:1985-12-21 标题 :Pyridine derivatives and the N-oxides thereof, and the use thereof as intermediates for the synthesis of plant protecting agents 发明人:FUSS ANDREAS; KOCH VOLKER 权利人:HOECHST AG 摘要:The compounds of the formula I (I) in which A denotes N or N->O, Z denotes O or NH, R denotes H, (halo)alkyl, (halo)alkenyl, (halo)alkynyl or alkoxycarbonyl, R1 denotes hydrogen, halogen, amino, -NHOH, hydroxyl, (substituted) phenylazo or a radical of the formulae Y=C=N-, Y1Y2C=N-, Y3NH- or K denotes 0 or 1, and m and n, independently of one another, denote a number from 1 to 4, with the proviso that, when Z-R denotes OH or NH2, (R1)n denotes at least one radical of the formula or represents two radicals, in the 5 or 6 position of the heterocyclic ring, which, in the 5 position, denote halogen and, in the 6 position, denote a radical of the group comprising halogen, amino, hydroxyl or phenylazo, which may be substituted as specified above, are valuable intermediates in the synthesis of plant protection agents.
专利号:EP-2084147-B1 优先权日:2006-08-29 标 题:Heterocyclic fxr binding compounds 发明人:KREMOSER CLAUS; DEUSCHLE ULRICH; ABEL ULRICH; SCHULZ ANDREAS 权利人:PHENEX PHARMACEUTICALS AG 摘要:The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists or partial agonists of the NR1H4 receptor (FXR). The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds, and to a process for the synthesis of said compounds.
专利号:US-5144038-A 优先权日:1990-07-17 标题:Process for the production of 2-hydroxy-3-halo-5-nitropyridines 发明人:WORSCH DETLEV 权利人:LONZA AG 摘要:A process for the production of 2-hydroxy-3-halo-5-nitropyridines, in which a 5-halo-6-hydroxynicotinic acid is nitrated in the end product. The resultant pyridines form valuable intermediate products for active ingredient synthesis.
专利号:US-9815842-B2 优先权日:2014-05-28 标题 :Pyrazolo pyrimidine derivatives and their use as MALT1 inhibitors 发明人:SOLDERMANN CAROLE PISSOT; QUANCARD JEAN; SCHLAPBACH ACHIM; SIMIC OLIVER; TINTELNOT-BLOMLEY MARINA; ZOLLER THOMAS 权利人:SOLDERMANN CAROLE PISSOT; QUANCARD JEAN; SCHLAPBACH ACHIM; SIMIC OLIVER; TINTELNOT-BLOMLEY MARINA; ZOLLER THOMAS; NOVARTIS AG 摘要:The present invention describes new pyrazolo-pyrimidine derivatives which are generally interacting with MALT1 proteolytic and/or autoproteolytic activity, and in particular which may inhibit said activity. The present invention further describes the synthesis of said new pyrazolo-pyrimidine derivatives, their use as a medicament, especially by interacting with MALT1 proteolytic and/or autoproteolytic activity.
专利号:CN-101781245-A 优先权日:2009-06-26 标题 :A new method for the synthesis of substituted pyridine-3-carboxylic acids and analogues
专利号:WO-2023071314-A1 优先权日:2021-10-29 标 题:Synthesis, preparation method and use of shp2 and cdk4/6 dual-target inhibitory compound
参考文献:10.1007/s00044-013-0814-y 摘要:Deka N, Uravane M, Anthony J, Bhumra SK, Nair A, B-Rao C, Patel D, Sivaramakrishnan H. Design and synthesis of non-TZD peroxisome proliferator-activated receptor γ (PPARγ) modulator. Medicinal Chemistry Research. 2013 Oct 10;23(4):2150–9. doi: 10.1007/s00044-013-0814-y. 参考文献:10.1007/s00706-022-02893-0 摘要:Wolińska E, Rozbicki P, Branowska D. Chiral pyridine oxazoline and 1,2,4-triazine oxazoline ligands incorporating electron-withdrawing substituents and their application in the Cu-catalyzed enantioselective nitroaldol reaction. Monatshefte für Chemie - Chemical Monthly. 2022 Feb 21;153(3):245–56. doi: 10.1007/s00706-022-02893-0.