CAS: 21717-96-4; 2-Amino-5-Fluoropyridine

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CAS号100304-88-9 2-乙酰氨基-5-氟吡啶 | CAS号31301-51-6 2-氯-5-氟吡啶 | CAS号127773-43-7 Difluoroboryl N... | CAS号4214-76-0 2-氨基-5-硝基吡啶 | CAS号327056-62-2 2-氰基-5-氟吡啶 | CAS号367500-93-4 6-氟咪唑[1,2-a]吡啶-... | CAS号41404-58-4 2-溴-5-氟吡啶 | CAS号212268-12-7 2-氨基-3-硝基-5-氟吡啶 | CAS号823218-51-5 2-氨基-5-氟-3-碘吡啶 | CAS号779345-37-8 5-氟-2-硝基吡啶 | CAS号869557-43-7 2-氨基-3-溴-5-氟吡啶 | CAS号784155-54-0 N-(5-氟吡啶-2-基)-2... | CAS号571189-16-7 4-(6-硝基-3-吡啶基)-... | CAS号571188-59-5 4-(6-氨基吡啶-3-基)哌...

2-氨基-3-硝基-5-氟吡啶置于硫酸,氯乙酸体系中,用 水 用作溶剂,化学反应生成2-氨基-5-氟吡啶
参考文献:具有抗细菌活性的三氮唑甲酯链接螺环类化 合物及其制备方法和应用
标题:具有抗细菌活性的三氮唑甲酯链接螺环类化 合物及其制备方法和应用
摘要:本发明公开了一种具有抗细菌活性的三氮唑甲酯链接螺环类化合物及其制备方法和应用,属于药物合成技术领域.本发明的技术方案要点为:一种具有抗细菌活性的三氮唑甲酯链接螺环类化合物,具有如下结构:本发明还公开了一种具有抗细菌活性的三氮唑甲酯链接螺环类化合物的制备方法.本发明通过新的方法合成了一种新型三氮唑甲酯链接螺环类化合物,反应过程操作简单易行,原料廉价易得,反应效率较高且重复性较好,对大肠杆菌的抑制效果明显.

专利信息

专利号:US-9828336-B2
优先权日:2012-02-17
标题:Methods and compounds useful in the synthesis of orexin-2 receptor antagonists
发明人：MONIZ GEORGE ANTHONY; WILCOXEN ANNIE ZHU; BENAYOUD FARID; TANAKA TOSHIAKI; SORIMACHI KEIICHI
权利人:EISAI R&D MAN CO LTD
摘要:The present disclosure provides compounds and methods that are useful for the preparation of compounds useful as orexin-2 receptor antagonists.

专利号:US-7405310-B2
优先权日:2001-03-05
标 题:Non-nucleoside reverse transcriptase inhibitors
发明人：LINDSTROM STEFAN; SAHLBERG CHRISTER; WALLBERG HANS; KALYANOV GENAIDY; ODEN LOURDES SALVADOR; NAESLUND LOTTA
权利人:MEDIVIR AB
摘要:This invention relates to non-nucleoside reverse transcriptase inhibitors active against HIV-1 and having an improved resistance and pharmacokinetic profile. The invention further relates to novel intermediates in the synthesis of such compounds and the use of the compounds in antiviral methods and compositions.

专利号:CN-104114524-B
优先权日:2012-02-17
标 题 :Methods and compounds for the synthesis of orexin-2 receptor antagonists

专利号:CA-2861493-C
优先权日:2012-02-17
标题:Methods and compounds useful in the synthesis of orexin-2 receptor antagonists

专利号:US-9416109-B2
优先权日:2012-02-17
标 题:Methods and compounds useful in the synthesis of orexin-2 receptor antagonists

专利号:US-10738028-B2
优先权日:2016-05-11
标题:Spiro three-membered ring, spiro five-membered ring peptide deformylase inhibitor and use thereof in antibacteria and anti-tumor
发明人：HU WENHAO; LV FENGPING; TANG YANG; LI ZIYAN; CHEN CHEN; WEI JIANHAI; DONG SUZHEN; QIAN YU
权利人:RUDONG RUIEN PHARMACEUTICAL TECH CO LTD
摘要:Disclosed are the anti-bacterial activity and the anti-tumor activity of a class of new spiro three-membered ring and spiro five-membered ring peptide deformylase inhibitor. The spiro three-membered ring and spiro five-membered ring peptide deformylase inhibitor of the present invention, as a class of new anti-bacterial agent, are effective against many antibiotic-resistant Gram-positive strains by inhibiting the activity of the peptide deformylase required in the synthesis of bacterial proteins, and do not affect the synthetic process of the main proteins of the human body, thus selectively killing bacteria. The spiro three-membered ring and spiro five-membered ring peptide deformylase inhibitor of the present invention, as a class of new anti-bacterial agent, can affect the energy balance of the cancer cells through inhibiting the peptide deformylase of the mitochondria in the cells, so that the mitochondrial membrane is depolarized, ATP is exhausted and cell apoptosis is promoted, and has good inhibitory activities on many cancer cell strains such as colorectal cancer, leukemia, lung cancer, gastric cancer, cervical cancer, breast cancer, prostatic cancer, liver cancer and osteosarcoma at relatively lower concentrations. The structure of exemplary invention spiro three-membered ring and spiro five-membered ring peptide deformylase inhibitors are represented by one or more of: