CAS: 20691-89-8; 1-Methyl-4-Piperidinemethanol

相似化合物

123855-51-6 122860-33-7 67686-01-5

上下游产品

CAS号24252-37-7 1-甲基-4-哌啶甲酸乙酯 | CAS号123855-51-6 N-B°C-4-哌啶甲醇 | CAS号36166-75-3 1-甲基-4-(羟甲基)-1,... | CAS号6457-49-4 4-哌啶甲醇 | CAS号50-00-0 甲醛 | CAS号1126-09-6 异哌啶酸乙酯 | CAS号1570-45-2 异烟酸乙酯 | CAS号1690-75-1 N-甲基-4-哌啶甲酸甲酯 | CAS号264208-72-2 4-氯-6-甲氧基-7-[(1... | CAS号102207-30-7 (1,1-dimethylpi... | CAS号902454-26-6 4-(1-甲基-4-哌啶基甲氧基)苯胺 | CAS号57295-18-8 (1-methyl-4-pip... | CAS号41632-36-4 (1,1-dimethylpi...

1-甲基-4-哌啶甲酸甲酯置于氢气,C28H25Brmnn2O2P,Lithium Tert-Butoxide体系中,用 丙醇 用作溶剂,100.0 °C,5.07 Mpa 条件下,反应 24.0H,以90%的收率获得1-甲基-4-哌啶甲醇
参考文献:锰催化剂加氢酯类
标题:锰催化剂加氢酯类
摘要:开发了膦-氨基吡啶配体锰络合物催化酯的氢化反应.使用该协议,各种(杂)芳香族和脂肪族羧酸盐(包括生物质衍生的酯和内酯)被氢化成伯醇,产率为 63-98%.发现锰催化剂对苯甲酸甲酯的氢化具有活性,可提供高达 45,000 的周转数 (Ton) 的苯甲醇.对催化剂中间体的研究表明,酰胺锰络合物是该反应的活性催化剂.
Doi:10.1002/adsc.202101376

专利信息

专利号:US-7825244-B2
优先权日:2005-06-10
标题:Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis
发明人：BAINDUR NAND; GAUL MICHAEL DAVID; KREUTTER KEVIN DOUGLAS; XU GUOZHANG
权利人:JANSSEN PHARMACEUTICA NV
摘要:The invention is directed to alkylquinoline and alkylquinazoline compounds of Formula C: n nwherein R 1 , R 2 , R 99 , and X are as defined herein, the use of such compounds in the synthesis of protein tyrosine kinase inhibitors, particularly inhibitors of FLT3 and/or c-kit and/or TrkB.

专利号:US-2007021436-A1
优先权日:2005-06-10
标 题 :Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis

专利号:CA-2611219-A1
优先权日:2005-06-10
标题 :Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators and related methods of synthesis

专利号:AU-2006258056-A1
优先权日:2005-06-10
标 题:Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators and related methods of synthesis

专利号:CN-101243065-A
优先权日:2005-06-10
标 题:Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators and related methods of synthesis

专利号:KR-20080033234-A
优先权日:2005-06-10
标 题 :Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators and related methods of synthesis