CAS: 205371-27-3; 2-(Tributylstannyl)Pyrazine

相似化合物

850501-37-0 850221-68-0 1447764-31-9

📜2-溴吡嗪,三丁基氯化锡置于正丁基锂体系中,用 乙醚,正己烷 用作溶剂,化学反应 18.0H,以82%的收率获得2-(三正丁基锡)吡嗪
参考文献:2-(2-吡啶基)吡嗪和2,2'-联吡嗪衍生物的合成与表征
标题:2-(2-吡啶基)吡嗪和2,2'-联吡嗪衍生物的合成与表征
摘要:报道了使用stille偶联从溴吡嗪衍生物中方便,高产地制备2-(2-吡啶基)吡嗪衍生物和2,2'-联吡嗪化合物衍生物的方法.给出了化合物的x射线结构,元素分析,1 H,13 C-NMR和质谱数据.
Doi:10.1002/jhet.3479

专利信息

专利号:US-9295679-B2
优先权日:2008-03-25
标 题:Prodrugs of C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activities, pharmacokinetics and antitumor activity
发明人：NJAR VINCENT; BRODIE ANGELA; GEDIYA LALJI K
权利人:UNIV MARYLAND
摘要:Prodrugs of steroidal C-17 benzoazoles, pyrimidinoazoles (az-abenzoazoles) and diazines. Methods of synthesis are also described, whereby a prodrug group is substituted for a functional group at A ring portion of the ABC ring structure of the steroid. Suitable pro-drug groups include amino acid groups, succinate groups, phosphate groups, or sulfamate groups. The prodrugs of the disclosed compounds allow for improved oral bioavailability of the compounds that are inhibitors of human CYP 17 enzyme as well as potent antagonists of both wild type and mutant androgen receptors (AR). The compounds and the corresponding prodrugs are useful for the treatment of conditions such as human prostate cancer, breast cancer, and prostate hyperplasia.

专利号:US-10098896-B2
优先权日:2005-03-02
标 题:C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens, in vitro biological activities, pharmacokinetics and antitumor activity
发明人：BRODIE ANGELA; NJAR VINCENT C O
权利人:THE UNIV OF MARYLAND BALTIMORE; UNIV MARYLAND
摘要:Described are steroidal C-17 benzoazoles, pyrimidinoazoles (azabenzoazoles) and diazines. Methods for their synthesis are also described, which include methods having a step of nucleophilic vinylic “addition-eliminationâ€? substitution reaction of 3β-acetoxy-17-chloro-16-formylandrosta-5,16-diene or analogs thereof and benzoazole or pyrimidinoazole nucleophiles and methods having a palladium catalyzed cross-coupling reaction of 17-iodoandrosta-5,16-dien-3β-ol or analogs thereof with tributylstannyl diazines. The compounds are potent inhibitors of human CYP17 enzyme as well as potent antagonists of both wild type and mutant androgen receptors (AR). The compounds are useful for the treatment of human prostate cancer.

专利号:US-11739082-B2
优先权日:2017-08-31
标 题 :Thiophene compounds, process for synthesis and use thereof
发明人：KOMIRISHETTY KASHINATH; VERMA MAHESH KUMAR; GANJU PARUL; PRASAD SUDHANAND
权利人:AHAMMUNE BIOSCIENCES PRIVATE LTD
摘要:The present invention relates to novel thiophene compounds of general Formula I, and their stereoisomers (diastereoisomers, enantiomers), pure or mixed, racemic mixtures, geometrical isomers, tautomers, pharmaceutically acceptable salts, hydrates, solvates, solid forms and mixtures thereof along with process for their preparation. The present invention discloses compounds that are useful in the treatment and prevention of autoimmune diseases.

专利号:US-2009137557-A1
优先权日:2005-11-22
标题 :Calcilytic Compounds
发明人：KU THOMAS WEN FU; LIN HONG; LUENGO JUAN I; MARQUIS JR ROBERT W; RAMANJULU JOSHI M; TROUT ROBERT; YAMASHITA DENNIS S
权利人:KU THOMAS WEN FU; LIN HONG; LUENGO JUAN I; MARQUIS JR ROBERT W; RAMANJULU JOSHI M; TROUT ROBERT; YAMASHITA DENNIS S
摘要:Novel calcilytic compounds, pharmaceutical compositions, methods of synthesis and methods of using them are provided.

专利号:US-9018198-B2
优先权日:2008-03-25
标题 :Prodrugs of C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activities, pharmacokinetics and antitumor activity

专利号:US-7875599-B2
优先权日:2005-03-02
标题:C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens, in vitro biological activities, pharmacokinetics and antitumor activity
发明人：BRODIE ANGELA; NJAR VINCENT
权利人:UNIV MARYLAND
摘要:Described are steroidal C-17 benzoazoles, pyrimidinoazoles (azabenzoazoles) and diazines. Methods for their synthesis are also described, which include methods having a step of nucleophilic vinylic “addition-eliminationâ€? substitution reaction of 3β-acetoxy-17-chloro-16-formylandrosta-5,16-diene or analogs thereof and benzoazole or pyrimidinoazole nucleophiles and methods having a palladium catalyzed cross-coupling reaction of 17-iodoandrosta-5,16-dien-3β-ol or analogs thereof with tributylstannyl diazines. The compounds are potent inhibitors of human CYP 17 enzyme as well as potent antagonists of both wild type and mutant androgen receptors (AR). The compounds are useful for the treatment of human prostate cancer.