CAS: 18202-73-8; Pivalimidamide Hydrochloride

相似化合物

22007-68-7 59950-56-0 57536-10-4

上下游产品

CAS号630-18-2 三甲基乙腈 | CAS号75-36-5 乙酰氯 | CAS号193610-95-6 2-叔丁基-6-(三氟甲基)嘧啶-4-醇 | CAS号18202-78-3 2-tert-butylpyr... | CAS号18378-79-5 2-叔丁基-4,6-二羟基嘧啶 | CAS号754-10-9 三甲基乙酰胺 | CAS号29650-96-2 Pivalate | CAS号70227-50-8 2-叔丁基-4-氯-5-硝基嘧啶 | CAS号59950-52-6 5-溴-2-叔丁基嘧啶-4-羧酸 | CAS号61319-99-1 (9CI)-2-(1,1-二甲...

📜三甲基乙腈置于盐酸,氨体系中,用 甲醇 用作溶剂,化学反应 3.0H,反应生成2,2-二甲基丙亚胺盐酸
参考文献:胍的合成:As作为胍基化剂的用途
标题:胍的合成:As作为胍基化剂的用途
摘要:据报道of可用于胍的串联或一锅合成.胍是通过将易得的稳定stable稳定氧化成碳二亚胺,然后与胺进行原位反应而获得的.该方案可以在绿色溶剂(碳酸二甲酯)中,在温和的反应条件下(30oc)执行.胺的范围很广,包括位阻胺,对氧化敏感的胺和手性胺.提供了合成无环和环状胍的实例.由氧化剂[ N-(p可以高产率地分离出[甲苯磺酰基]亚氨基](2-丙氧基苯基)碘烷(2-Prophints),从而使高价碘试剂的再生成为可能.合成方法与最新技术相比,其实用性和绿色性通过抗高血压药物pinacidil的新途径得以证明.新路线的过程质量强度(pmi)仅是经典路线的24%.
Doi:10.1002/adsc.201501146

专利信息

专利号:US-7897762-B2
优先权日:2006-09-14
标 题:Kinase inhibitors useful for the treatment of proliferative diseases
发明人：FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C
权利人:DECIPHERA PHARMACEUTICALS LLC
摘要:The present invention relates to novel kinase inhibitors and modulator compounds useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.

专利号:US-9018387-B2
优先权日:2010-06-11
标 题:Complexes of imidazole ligands
发明人：NORMAN JOHN ANTHONY THOMAS; PEREZ MELANIE K; LEI XINJIAN; SPENCE DANIEL P; IVANOV SERGEI VLADIMIROVICH; BAILEY III WADE HAMPTON
权利人:NORMAN JOHN ANTHONY THOMAS; PEREZ MELANIE K; LEI XINJIAN; SPENCE DANIEL P; IVANOV SERGEI VLADIMIROVICH; BAILEY III WADE HAMPTON; AIR PROD & CHEM
摘要:Metal imidazolate complexes are described where imidazoles ligands functionalized with bulky groups and their anionic counterpart, i.e., imidazolates are described. Compounds comprising one or more such polyalkylated imidazolate anions coordinated to a metal or more than one metal, selected from the group consisting of alkali metals, transition metals, lanthanide metals, actinide metals, main group metals, including the chalcogenides, are contemplated. Alternatively, multiple different imidazole anions, in addition to other different anions, can be coordinated to metals to make new complexes. The synthesis of novel compounds and their use to form thin metal containing films is also contemplated.

专利号:US-8188113-B2
优先权日:2006-09-14
标 题 :Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
发明人：FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C
权利人:FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C; DECIPHERA PHARMACEUTICALS INC
摘要:The present invention relates to novel dihydropyridopyrimidinyl, dihydronaphthyridinyl, and related compounds which are kinase inhibitors and modulator useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.

专利号:US-8703103-B2
优先权日:2010-02-05
标题 :Volatile imidazoles and group 2 imidazole based metal precursors
发明人：NORMAN JOHN ANTHONY THOMAS; PEREZ MELANIE K; KIM MOO-SUNG
权利人:NORMAN JOHN ANTHONY THOMAS; PEREZ MELANIE K; KIM MOO-SUNG; AIR PROD & CHEM
摘要:Sterically hindered imidazole ligands are described, along with their synthesis, which are capable of coordinating to Group 2 metals, such as: calcium, magnesium, strontium, in an eta-5 coordination mode which permits the formation of monomeric or dimeric volatile complexes. n A compound comprising one or more polysubstituted imidazolate anions coordinated to a metal selected from the group consisting of barium, strontium, magnesium, radium or calcium or mixtures thereof. Alternatively, one anion can be substituted with and a second non-imidazolate anion. n Synthesis of the novel compounds and their use to form BST films is also contemplated.

专利号:TW-572896-B
优先权日:2000-05-26
标 题:Process for the synthesis of amine ethers from secondary amino oxides

专利号:TW-200811122-A
优先权日:2006-03-27
标题:A convergent process for the synthesis of taxane derivatives