CAS: 17996-13-3; Benzyl (4-Hydroxybutyl)Carbamate

该化合物是一种多用途氨基酒精化合物,具有氢氧基和氨基功能组,对有机合成和制药应用很有价值,其双功能结构使该化合物能够用作制作异性循环,离心和生物活性分子的构件.该化合物的主要氨基组可以进一步衍生,而氢氧基组则能增加极溶剂的溶解性和再活性.由于其潜在的手性能,该混合物在不对称合成和催化中特别有用.建议谨慎处理,因为其反应性质.高纯度等级确保研究和工业流程的一贯性能.

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CAS号13325-10-5 4-氨基-1-丁醇 | CAS号501-53-1 氯甲酸苄酯 | CAS号14468-80-5 1-Z-2-吡咯烷酮 | CAS号13139-17-8 苯甲氧羰酰琥珀酰亚胺 | CAS号1346132-49-7 benzyl (4-((ter... | CAS号67706-63-2 methyl 4-(pheny... | CAS号137160-76-0 丙酮O-(苄氧羰基)肟 | CAS号101625-10-9 (4-溴丁基)氨基甲酸苄酯 | CAS号3482-41-5 1-(4-hydroxybut... | CAS号174626-26-7 4-(phenylmethox... | CAS号25070-74-0 1-Cbz-吡咯烷 | CAS号69261-54-7 benzyl 2-hydrox... | CAS号62146-62-7 N-(苄氧羰基)-1,4-丁二胺

合成工艺路线路线简述

    📜2-氧代吡咯烷-1-羧酸苄酯置于cp*rucl{(C6H5)2P-(Ch2)2Nh2-κ2-P,N},Potassium Tert-Butylate,氢气体系中,用 叔丁醇 用作溶剂,80.0 °C,3.0 Mpa 条件下,反应 24.0H,以92%的收率获得4-(Z-氨基)-1-丁醇
    参考文献:双官能[cp * Ru(pn)]配合物催化的n-酰基氨基甲酸酯和n-酰基磺酰胺的加氢反应
    标题:双官能[cp * Ru(pn)]配合物催化的n-酰基氨基甲酸酯和n-酰基磺酰胺的加氢反应
    摘要:Cp 1的唤醒:双功能配合物1促进了与具有比酮,环氧化物和酰亚胺少的亲电子碳原子的底物的相互作用.该标题反应适用于将埃文斯的不对称烷基化产物还原为手性醇,以及非常好的手性恶唑烷酮助剂的回收率.Ewg =吸电子基团.
    Doi:10.1002/anie.200805307

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    专利信息


    专利号:US-11440881-B2
    优先权日:2019-05-09
    标题 :Thiosemicarbazates and uses thereof
    发明人：AL-ABED YOUSEF; ALTITI AHMAD
    权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
    摘要:Thioesters, thiocarbamates, thiocarbazates, semithiocarbazates, peptides, aza-amino acid conjugates, and azapeptides; and a chemoselective and site-specific functionalization protocol of protected thiocarbazates and semithiocarbazates are described. The protocol features the use of Mitsunobu reaction to alkylate specifically the nitrogen atom close to the acylthiol moiety with alcohols to produce protected mono-substituted thiocarbazates that can be stored for months, activated under mild conditions at low temperature using halonium reagents and integrated orthogonally to make substituted semicarbazides that can be used, e.g., as synthons in synthesis of aza-amino acid conjugates, azapeptides and other peptidomimetics. Methods for preparing and using ureases, carbazides, semicarbazides, beta-peptides, azapeptides, and other peptidomimetics and azapeptide conjugates, and uses of ureases, carbazides, semicarbazides, beta-peptides, azapeptides in drug discovery, diagnosis, inhibition, prevention and treatment of diseases are also described.

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    主要参考文献

    参考标题: Thiosemicarbazates And Uses Thereof Thiosemicarbazates Et Leurs Utilisations
    摘要:Thioesters, Thiocarbamates, Thiocarbazates, Semithiocarbazates, Peptides, Aza-Amino Acid Conjugates, And Azapeptides; And A Chemoselective And Site-Specific Functionalization Protocol Of Protected Thiocarbazates And Semithiocarbazates Are Described. The Protocol Features The Use Of Mitsunobu Reaction To Alkylate Specifically The Nitrogen Atom Close To The Acylthiol Moiety With Alcohols To Produce Protected Mono-Substituted Thiocarbazates That Can Be Stored For Months, Activated Under Mild Conditions At Low Temperature Using Halonium Reagents And Integrated Orthogonally To Make Substituted Semicarbazides That Can Be Used, E.G., As Synthons In Synthesis Of Aza-Amino Acid Conjugates, Azapeptides And Other Peptidomimetics. Methods For Preparing And Using Ureases, Carbazides, Semicarbazides, Beta-Peptides, Azapeptides, And Other Peptidomimetics And Azapeptide Conjugates, And Uses Of Ureases, Carbazides, Semicarbazides, Beta-Peptides, Azapeptides In Drug Discovery, Diagnosis, Inhibition, Prevention And Treatment Of Diseases Are Also Described.

    合成参考文献


    摘要:Ziegler, T., Science of Synthesis, (2005) 21, 49.
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