CAS: 1445-75-6; Diisopropyl Methylphosphonate

该化合物是一种有机磷化合物,其结构特征包括两个异丙基化合物和甲基磷酸酯,对粉黄黄色液而言,其色素微弱味和溶解于有机溶剂中,但水溶解性有限,该化合物以其用作化学中间体和各种有机磷化合物合成而闻名,具有磷酸的典型特性,包括潜在毒性和作为...

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methyl bromide triisopropyl phosphite methylphosphonic acid dichloroanhydride isopropyl alcoholmethylphosphonic chloride isopropyl ester methylphosphonic acid dichloroanhydride methylphosphonic acid isopropyl ester ((E)-2-Hydroxy-4-phenyl-but-3-enyl)-phosphonic acid diisopropyl ester

合成工艺路线路线简述

  • 合成目标产物 Diisopropyl Methylphosphonate 主要起始原料 Triisopropyl Phosphite And Iodomethane
  • (文献来源)合成步骤主要原料 Triisopropyl Phosphite 和 Iodomethane
Methyl-Di(Propan-2-Yloxy)-Selanylidene-Lambda5-Phosphane置于oxone体系中,用 四氢呋喃,甲醇 用作溶剂,以80%的收率获得甲基磷酸二异丙酯
参考文献:Oxidation In Organophosphorus Chemistry: Potassium Peroxymonosulphate
标题:Oxidation In Organophosphorus Chemistry: Potassium Peroxymonosulphate
摘要:
Doi:10.1016/s0040-4039(99)00261-0

海关参考信息

专利信息


专利号:US-2015099864-A1
优先权日:2013-10-08
标题:Preparation of organophosphate peptide adducts
发明人:BREWER BOBBY N; LUCAS ERIC A; BURKITT NATHAN T
权利人:BATTELLE MEMORIAL INSTITUTE
摘要:Disclosed are methods for the synthesis of organophosphorus-adducted peptides. Such peptides may be useful as biomarkers of organophosphate exposure, or for the synthesis of antibodies. Also disclosed are peptide adducts including peptide adducts of tabun, and aged adducts.

专利号:US-6204398-B1
优先权日:1996-08-23
标题 :Preparation of cyclohexene carboxylate derivatives
发明人:KENT KENNETH M; KIM CHOUNG U; MCGEE LAWRENCE R; MUNGER JOHN D; PRISBE ERNEST J; POSTICH MICHAEL J; ROHLOFF JOHN C; KELLY DAPHNE E; WILLIAMS MATTHEW A; ZHANG LIJUN
权利人:GILEAD SCIENCES INC
摘要:The present invention provides new synthetic methods and compositions. In particular, new methods of preparing intermediates such as those having formulas (I)-(IV), useful in the synthesis of neuraminidase inhibitors and compositions useful as intermediates that are themselves useful in the synthesis of neuraminidase inhibitors are provided.

专利号:WO-2015053980-A1
优先权日:2013-10-08
标 题 :Preparation of organophosphate peptide adducts
发明人:BREWER BOBBY N; LUCAS ERIC A; BURKITT NATHAN T
权利人:BATTELLE MEMORIAL INSTITUTE
摘要:Disclosed are methods for the synthesis of organophosphorus-adducted peptides. Such peptides may be useful as biomarkers of organophosphate exposure, or for the synthesis of antibodies. Also disclosed are peptide adducts including peptide adducts of tabun, and aged adducts.

专利号:US-6608196-B2
优先权日:2001-05-03
标题 :Process for solid supported synthesis of pyruvate-derived compounds
发明人:WANG BING; JANAGANI SATYANARAYANA; CALLAWAY WYETH B; SESSLER JONATHAN L
权利人:GALILEO PHARMACEUTICALS INC
摘要:Provided are processes for synthesizing structurally diverse pyruvate-derived compounds using a parallel approach on a solid phase support. Examples of such a solid phase support include resins which have also been used in solid phase peptide synthesis.

专利号:US-9522932-B2
优先权日:2004-03-04
标 题 :Phosphonate nucleosides useful as active ingredients in pharmaceutical compositions for the treatment of viral infections, and intermediates for their production
发明人:HERDEWIJN PIET; PANNECOUQUE CHRISTOPHE; WU TONGFEI; DE CLERCQ ERIK
权利人:LEUVEN K U RES & DEV
摘要:The invention is directed to a process for the preparation of substituted threonolactone and substituted threose compounds which are intermediates in the synthesis of phosphonate nucleosides being useful antiviral agents.

专利号:US-2006106178-A1
优先权日:2002-08-06
标题:Synthesis of statistical microgels by means of controlled radical polymerisation
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合成参考文献


摘要:Drabowicz, J.; Kiełbasiński, P.; Łyżwa, P.; Mikołajczyk, M.; Zając, A., Science of Synthesis, (2009) 42, 713.
摘要:Kimura, T., Science of Synthesis Knowledge Updates, (2016) 2, 442.
摘要:Kimura, T., Science of Synthesis Knowledge Updates, (2016) 2, 443.
摘要:Virieux, D.; Ayad, T.; Pirat, J.-L.; Volle, J.-N., Science of Synthesis Knowledge Updates, (2018) 1, 282.
摘要:Proceedings of the International Congress on Toxicology, Toxicology as a Predictive Science, 1st, Toronto, 1977, Plaa, G.L., and W.A. Duncan, eds., New York, Academic Press, Inc., 1978, -(450), 1978
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