CAS: 1380500-92-4; 2-(4-(1,2,4,5-Tetrazin-3-yl)Phenyl)Acetic Acid

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1380500-88-8 1345866-66-1 1380500-87-7

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4-cyanophenylacetic acid formamidine acetic acid dichloromethane 3-(4-phenylacetic acid)-1,2,4,5-tetrazine succinimidyl ester

合成工艺路线路线简述

    📜4-氰基苯乙酸,醋酸甲脒置于nickel(II) Triflate,肼,盐酸,Sodium Nitrite体系中,用 水 用作溶剂,化学反应 24.0H,以74%的收率获得酸四嗪
    参考文献:直接从脂肪腈和肼金属催化一锅法合成四嗪
    标题:直接从脂肪腈和肼金属催化一锅法合成四嗪
    摘要:铺路:缺乏方便的合成方法是 1,2,4,5-四嗪在生物正交化学和功能材料中更广泛使用的重大障碍.路易斯酸金属催化剂--最显着的是二价镍和锌盐--被描述为直接从脂肪腈催化一锅法合成 1,2,4,5-四嗪(见方案).
    Doi:10.1002/anie.201201117

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    专利信息


    专利号:US-2017198217-A1
    优先权日:2015-09-04
    标题 :Synthesis of nanocrystals

    专利号:US-9533957-B2
    优先权日:2012-04-06
    标题:Tetrazines and method of synthezising the same
    发明人：DEVARAJ NEAL K; YANG JUN
    权利人:UNIV CALIFORNIA
    摘要:Provided herein, inter alia, are compositions and methods of synthesis and detection of tetrazines, e.g., a tetrazine of formula n nand diazonorcaradienes.

    专利号:US-10711183-B2
    优先权日:2015-09-04
    标 题:Synthesis of nanocrystals
    发明人：CORDERO JOSE M; CHEN YUE; BAWENDI MOUNGI G
    权利人:MASSACHUSETTS INST TECHNOLOGY
    摘要:A nanocrystal composition can include a nanocrystal and an outer layer including a ligand bound to the nanocrystal, wherein the ligand includes a norbornene group and a carboxyl group.

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    主要参考文献


    1: Sano K, Nakajima T, Miyazaki K, Ohuchi Y, Ikegami T, Choyke PL, Kobayashi H. Short PEG-linkers improve the performance of targeted, activatable monoclonal antibody-indocyanine green optical imaging probes. Bioconjug Chem. 2013 May 15;24(5):811-6. doi: 10.1021/bc400050k. Epub 2013 May 3.
    2: Harrison E, Coulter JA, Dixon D. Gold nanoparticle surface functionalization: mixed monolayer versus hetero bifunctional peg linker. Nanomedicine (Lond). 2016 Apr;11(7):851-65. Review. pii: E1190. doi: 10.3390/molecules22071190.
    4: Tuma R, Russell M, Rosendahl M, Thomas GJ Jr. Solution conformation of the extracellular domain of the human tumor necrosis factor receptor probed by Raman and UV-resonance Raman spectroscopy: structural effects of an engineered PEG linker. Biochemistry. 1995 Nov 21;34(46):15150-6. doi:10.1016/j.jconrel.2016.02.017. Epub 2016 Feb 8.

    合成参考文献


    摘要:Kuba, W.; Wilkovitsch, M.; Carlson, J. C. T.; Mikula, H., Science of Synthesis, (2021) , 582.
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