CAS: 1370651-20-9; 6-Amino-5-((R)-1-(2,6-Dichloro-3-Fluorophenyl)Ethoxy)-N-(4-((3R,5S)-3,5-Dimethylpiperazine-1-Carbonyl)Phenyl)Pyridazine-3-Carboxamide
- 英文名称6-Amino-5-((R)-1-(2,6-Dichloro-3-Fluorophenyl)Ethoxy)-N-(4-((3R,5S)-3,5-Dimethylpiperazine-1-Carbonyl)Phenyl)Pyridazine-3-Carboxamide
- 中文名称恩沙替尼
- IUPAC名称6-amino-5-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)-N-(4-((3R,5S)-3,5-dimethylpiperazine-1-carbonyl)phenyl)pyridazine-3-carboxamide
- 其它别名C26H27Cl2Fn6O3; Ensartinib; 3-Pyridazinecarboxamide, 6-Amino-5-[(1R)-1-(2,6-Dichloro-3-Fluorophenyl)Ethoxy]-N-[4-[[(3R,5S)-3,5-Dimethyl-1-Piperazinyl]Carbonyl]Phenyl]-; 6-Amino-5-[(1R)-1-(2,6-Dichloro-3-Fluorophenyl)Ethoxy]-N-{4-[(3R,5S)-3,5-Dimethylpiperazine-1-Carbonyl]Phenyl}Pyridazine-3-Carboxamide; 6-Amino-5-((R)-1-(2,6-Dichloro-3-Fluorophenyl)Ethoxy)-N-(4-((3R,5S)-3,5-Dimethylpiperazine-1-Carbonyl)Phenyl)Pyridazine-3-Carboxamide
- CAS编号1370651-20-9
- MFCD编号:MFCD31631377
- FDA UNII编号:SMA5ZS5B22
- 分子式:C26H27Cl2FN6O3分子量:561.45
- 产品CID: 577756
- 同类组份化合物CAS2137030-98-7 (HCl)1370651-20-9 (free base)
- 产品分类医药中间体
物理性质
MSDS等安全信息
合成工艺路线路线简述
📜以24.6的收率获得爱沙替尼
参考文献:Substituted Pyridazine Carboxamide Compounds
标题:Substituted Pyridazine Carboxamide Compounds
摘要:新的吡啶嗪衍生物具有意想不到的药物特性,作为蛋白激酶抑制剂,尤其对alk具有作用,并且在治疗与异常蛋白激酶活性相关的疾病,如癌症,神经和精神疾病方面是有用的.
海关参考信息
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2903919090-氯苯
2906210000-苄醇
2912110000-甲醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
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📌 第三方产品分析报告
主要参考文献
1: Insights into ALK-driven cancers revealed through development of novel ALK tyrosine kinase inhibitors Christine M. Lovly, Johannes M. Heuckmann, Elisa de Stanchina, Heidi Chen, Roman K. Thomas, Chris Liang, William Pao Cancer Res. Author manuscript; available in PMC 2012 July 15.Published in final edited form as: Cancer Res. 2011 July 15; 71(14): 4920–4931. Published online 2011 May 25. doi: 10.1158/0008-5472.CAN-10-3879 Palmer F1000 Med Rep. 2011;
3: 21. Published online 2011 November 1. doi: 10.3410/M3-21 2014;
4: 174. Prepublished online 2014 June 6. Published online 2014 July 21. doi: 10.3389/fonc.2014.00174 2012;
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