CAS: 111011-76-8; 2-(Benzyl(Phenyl)Amino)Ethyl 5-(5,5-Dimethyl-2-Oxido-1,3,2-Dioxaphosphinan-2-yl)-2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3-Carboxylate Ethanol Hydrochloride

该化合物是一种主要用作抗血压剂的钙管阻塞器,其化学结构含有单乙醇溶液,增强稳定性和溶性,这对配制和生物利用率至关重要.该化合物有选择地抑制L型钙渠道,导致血管变异和外围血管抗药性降低.其药用动力学剖面剖面包括逐渐开始和延长动作,最大限度地减少突发的热动波动.单乙醇形式确保了一致的晶体特性,便利了药物应用中的精确剂量.对于其肾脏保护效果,特别注意到了亚硝基磺酸盐单乙酸盐,使其适合有共性肾脏症状的高血压病人.其精密的合成和纯度标准支持可靠的临床性能.

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    专利信息


    专利号:US-7399794-B2
    优先权日:2004-04-28
    标 题 :Polymer/carbon nanotube composites, methods of use and methods of synthesis thereof
    发明人:HARMON JULIE P; CLAYTON LANETRA M
    权利人:UNIV SOUTH FLORIDA
    摘要:Novel transparent composites composed of single wall carbon nanotubes incorporated into the matrix of a polymer are utilized in services wherein the composites are exposed to ionizing radiation, including galactic cosmic radiation. Accordingly, the composites are useful in deep space applications like space vehicles, space stations, personal equipment as well as applications in the biomedical arts and atom splitting research. The composites can be modified with organic dyes containing at least one phenyl ring and the resulting doped composite is useful as a radiation detector. The preferred polymer is poly(4-methyl-1-pentene).

    专利号:US-5066753-A
    优先权日:1987-12-21
    标 题 :Polymerizable cationic viscoelastic monomer fluids
    发明人:PEIFFER DENNIS G
    权利人:EXXON RESEARCH ENGINEERING CO
    摘要:The synthesis of a novel family of cationic monomers capable of forming viscoelastic fluids are described within. These monomers are formed primarily through the reaction of allyl halides and dimethyl alkylamines. The rheological properties of the fluids can be dramatically modified with changes in alkyl length and/or counterion structure. In addition, it is noted that these viscoelastic fluids have properties quite similar to conventional polymer solutions even though the former structures are held together through physical forces and not through chemical bonding as in the latter materials. In addition, the properties of this unique family of cationic monomers are capable of forming viscoelastic fluids in high brine solutions. Even though the counterion attached to the monomer contributes greatly to the rheological properties, addition of soluble acid, bases and salts do not destroy (through ion exchange mechanisms) the viscoelastic properties of these fluids.

    专利号:US-2005245667-A1
    优先权日:2004-04-28
    标 题:Polymer/carbon nanotube composites, methods of use and methods of synthesis thereof

    专利号:US-2008306184-A1
    优先权日:2004-04-28
    标题 :Polymer/carbon nanotube composites, methods of use and methods of synthesis thereof

    专利号:WO-2006073454-A9
    优先权日:2004-04-28
    标题 :Polymer/carbon nanotube composites, methods of use and methods of synthesis thereof

    专利号:WO-2006073454-A2
    优先权日:2004-04-28
    标题:Polymer/carbon nanotube composites, methods of use and methods of synthesis thereof

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    1: Liu M, Zhao H, Tong Y, Zhang D, Wang X, Zhang L, Han J, Liu H. Determination of efonidipine in human plasma by LC-MS/MS for pharmacokinetic applications. J Pharm Biomed Anal. 2014 Nov 11;103C:1-6. doi: 10.1016/j.jpba.2014.11.001. [Epub ahead of print] doi: 10.1016/j.vph.2013.07.005. Epub 2013 Jul 19. doi: 10.1097/HJH.0b013e3283550e9f. doi: 10.4070/kcj.2012.42.4.229. Epub 2012 Apr 26.
    5: Li C, Choi DH, Choi JS. Effects of efonidipine on the pharmacokinetics and pharmacodynamics of repaglinide: possible role of CYP3A4 and P-glycoprotein inhibition by efonidipine. J Pharmacokinet Pharmacodyn. 2012 Feb;39(1):99-108. doi: 10.1007/s10928-011-9234-0. Epub 2012 Jan 1. Epub 2011 Sep 7.
    7: Ikeda K, Saito T, Tojo K. Efonidipine, a Ca(2+)-channel blocker, enhances the production of dehydroepiandrosterone sulfate in NCI-H295R human adrenocortical carcinoma cells. Tohoku J Exp Med. 2011;224(4):263-71. doi: 10.4070/kcj.2010.40.10.514. Epub 2010 Oct 31.

    合成参考文献


    参考文献:10.1140/epje/i2002-10005-5
    摘要:Hotta A, Terentjev EM. Dynamic soft elasticity in monodomain nematic elastomers. Eur Phys J E Soft Matter. 2003 Apr;10(4):291–301. doi: 10.1140/epje/i2002-10005-5.
    参考文献:10.1186/s12957-019-1650-4
    摘要:Bains L, Lal P, Vindal A, Singh M. Giant villous adenoma of rectum- what is the malignant potential and what is the optimal treatment A case and review of literature. World Journal of Surgical Oncology. 2019 Jun 25;17(1):109. doi: 10.1186/s12957-019-1650-4.
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