CAS: 105-07-7; 4-Formylbenzonitrile

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100-21-0 619-66-9 623-27-8

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2-溴-4'-氰基苯乙酮置于sodium Azide体系中,用 乙醇,水,溶剂黄146,甲苯 用作溶剂,化学反应生成4-氰基苯甲醛
参考文献:α-叠氮基苯乙酮的光解:直接检测溶液中的三重烷基氮.
标题:α-叠氮基苯乙酮的光解:直接检测溶液中的三重烷基氮.
摘要:我们报告了通过α-叠氮基苯乙酮衍生物的激光闪光光解法对液体溶液中的三重态烷基氮的首次检测.1.叠氮化物1包含分子内三重态敏化剂,可通过绕过单重态氮烯中间体确保三重态烷基氮的形成.在室温下,叠氮化物1裂解形成苯甲酰基和叠氮化物自由基,与三重态能量转移竞争形成三重态烷基氮.主要的光产物3是由于三重烷基亚硝基被苯甲酰基所拦截而产生的.三线态烷基腈中间体也被分子氧捕获,得到相应的2-硝基苯基乙酮.1的激光闪光光解表明,三线态烷基腈具有约300 Nm的吸收.通过在氩气基质中获得它们的uv和ir光谱,进一步表征了三线态烷基氮烯.(13)c和(15)n同位素标记研究使我们能够表征1201 Cm(-)(1)处的丁腈中间体的cn延伸.
Doi:10.1021/jo034674E

专利信息

专利号:US-8410320-B2
优先权日:2010-12-07
标 题 :Method for synthesis of secondary alcohols
发明人：CHENG CHIEN-HONG; KARTHIKEYAN JAGANATHAN; HUANG PANG-CHI
权利人:CHENG CHIEN-HONG; KARTHIKEYAN JAGANATHAN; HUANG PANG-CHI; NAT UNIV TSING HUA
摘要:A method for synthesis of secondary alcohols is provided for pharmaceutical secondary alcohol by addition of organoboronic acids with aldehydes in presence of the cobalt ion and bidentate ligands as the catalyst. In addition, an enantioselective synthesis method for secondary alcohols is also herein provided in the present invention. The present invention has advantages in using less expensive cobalt ion and commercially available chiral ligands as the catalyst, wide scope of organoboronic acids and aldehydes compatible with this catalytic reaction and achieving excellent yields and/or enantiomeric excess.

专利号:US-2025188046-A1
优先权日:2023-12-08
标题:Ultrafast flow synthesis of functionalized sulfonyl fluorides and subsequent sufex connections via lithiated chemistry
发明人：KIM DONG-PYO; KANG JI-HO
权利人:POSTECH RES & BUSINESS DEV FOUND
摘要:Disclosed are ultrafast flow synthesis of functionalized sulfonyl fluorides and subsequent SuFEx connections via lithiated chemistry. In detail, a method of synthesizing an ortho-functionalized benzenesulfonyl fluoride derivative, the method comprises (a) reacting a benzenesulfonyl fluoride derivative represented by structural formula 1 with an organolithium represented by structural formula 2, thus synthesizing an intermediate represented by structural formula 3 in reaction scheme 1 and (b) reacting the intermediate with an electrophile, thus synthesizing a compound represented by structural formula 4 or a compound represented by structural formula 4′. The present disclosure enables the synthesis of several functionalized sulfonyl fluorides within a few seconds under mild temperature conditions in addition to the chemistry of Sulfonyl Fluoride Exchange (SuFEx), which is a next-generation click chemistry, so that sulfonyl fluoride, the main reactant of the SuFEx reaction, can be efficiently secured.

专利号:US-9242925-B2
优先权日:2011-08-29
标题:Versatile and stereospecific synthesis of γ,δ-unsaturated amino acids by Wittig reaction
发明人：JUGE SYLVAIN; BAYARDON JEROME; REMOND EMMANUELLE; ONDEL-EYMIN MARIE-JOELLE
权利人:JUGE SYLVAIN; BAYARDON JEROME; REMOND EMMANUELLE; ONDEL-EYMIN MARIE-JOELLE; CENTRE NAT RECH SCIENT; UNIV BOURGOGNE
摘要:The γ,δ-unsaturated α-amino acids of general formula (I). Also, a versatile process for the stereospecific synthesis of said compounds of formula (I), involving a Wittig reaction. Further, intermediate products of general formulae (II) and (III), as shown below, which are involved in the synthesis of compounds (I). n n n n n n n n n n n n Compounds of general formula (I) may be useful as therapeutic substances, or as reagents or intermediates for fine chemistry.

专利号:US-10266565-B2
优先权日:2011-04-12
标 题 :Peptide mimetic ligands of polo-like kinase 1 polo box domain and methods of use
发明人：BURKE JR TERRENCE R; LIU FA; LEE KYUNG S; PARK JUNG-EUN
权利人:BURKE JR TERRENCE R; LIU FA; LEE KYUNG S; PARK JUNG EUN; THE US SECRETARY DEPARTMENT OF HEALTH & HUMAN SERVICES
摘要:Novel compounds are provided that bind to polo-like kinases through the polo-box domain. In certain embodiments, the novel compounds are PEGylated peptides. The PEGylated peptides in accordance with the invention demonstrate high PBD-binding affinity. In certain embodiments, the PEGylated peptides have also achieved activities in whole cell systems. The invention also provides compounds that bind polo-like kinases through the polo-box domain and possess reduced anionic charge. Further provided are methods of design and/or synthesis of the PEGylated peptides and methods of use thereof. The invention provides methods of use of the compounds and methods of synthesis of the compounds.

专利号:US-8283502-B2
优先权日:2009-04-09
标题:Autocatalytic process for the synthesis of chiral propargylic alcohols
发明人：CHINKOV NICKA; WARM ALEKSANDER; CARREIRA ERICK
权利人:CHINKOV NICKA; WARM ALEKSANDER; CARREIRA ERICK; LONZA AG
摘要:An autocatalytic process for the synthesis of chiral propargylic alcohols.

专利号:WO-2014037963-A1
优先权日:2012-09-06
标 题 :A PROCESS FOR THE SYNTHESIS OF β, Æ´ UNSATURATED KETONES
发明人：MHASKE SANTOSH BABURAO; AHIRE MILIND MUKUND
权利人:COUNCIL SCIENT IND RES
摘要:The present invention disclose Pd/ N -Heterocyclic carbene catalyzed one step process for synthesis of β, Æ´-unsaturated ketones by direct acylation of allylic Carbons with aldehydes.