CAS: 927-77-5; N-Propylmagnesium Bromide

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CAS号106-94-5 溴代丙烷 | CAS号10531-16-5 4-丁基苄溴 | CAS号10544-95-3 4-methyl°Ctadecane | CAS号107680-32-0 (2R,3S)-2-(2,4-... | CAS号106230-25-5 8-chloro°Ctan-4-one | CAS号39836-21-0 顺-9-二十一碳烯 | CAS号563-16-6 3,3-二甲基己烷 | CAS号5445-24-9 1-正丙基环己醇 | CAS号4383-18-0 2-苯基-2-戊醇 | CAS号7433-56-9 反式-5-癸烯 | CAS号55454-22-3 (Z)-2-Hepten-1-ol

溴丙烷置于magnesium体系中,用 乙醚 作为反应溶剂,化学反应生成 丙基溴化镁
参考文献:4-Alkyl-3-Azidomethyl-2-Ethoxy-2,5-Dihydro-5H-1,2-Oxaphosphole 2-Oxides: Synthesis And 1,3-Cycloaddition
标题:4-Alkyl-3-Azidomethyl-2-Ethoxy-2,5-Dihydro-5H-1,2-Oxaphosphole 2-Oxides: Synthesis And 1,3-Cycloaddition
摘要:从磷酸化的丙二烯开始,开发了一种具有 1,2-氧杂磷烯碳骨架的新型有机叠氮化物的三步合成.该系列得到的4-烷基-3-叠氮基甲基-2-乙氧基-2,5-二氢-5-ħ-1,2-Oxaphosphole 2氧化物中使用了1,3-环加成与烷基2-[1-(Propyn-2-yl)-1 H-Indol-3-Yl]-2-Oxoacetates 用于合成偶联物,这是潜在的活性细胞抑制剂.
DOI:10.1055/s-0040-1720922

专利信息

专利号:US-4501921-A
优先权日:1982-11-18
标题 :Synthesis of alkylidene intermediates
发明人：RYAN CHARLES W; SLOMSKI BRUCE A
权利人:LILLY CO ELI
摘要:A stereo-selective preparation of novel sulfonated o-phenylenediamines carrying a trans-α-alkylidenebenzyl group at the 5-position, which are intermediates in the synthesis of antiviral benzimidazoles.

专利号:US-8674119-B2
优先权日:2010-07-16
标题 :Chemical processes for the manufacture of substituted benzofurans
发明人：FLYNN BERNARD LUKE
权利人:FLYNN BERNARD LUKE; BIONOMICS LTD
摘要:The present invention relates to the scaled-up synthesis of biologically active compounds which display useful therapeutic activity in treating proliferative disorders. In particular the invention relates to process methods for the kilogram scale synthesis of a particular class of substituted benzofuran tubulin polymerisation inhibitors.

专利号:US-6340751-B1
优先权日:1998-07-24
标 题 :Process for the preparation of 4-substituted azetidinone derivatives
发明人：SAITO TAKAO; MURAYAMA TOSHIYUKI; MATSUMOTO TAKAJI; MIURA TAKASHI
权利人:TAKASAGO PERFUMERY CO LTD
摘要:Disclosed is a process for the preparation of a 4-substituted azetidinone derivative, which comprises reacting an azetidinone derivative and an amide compound in the presence of a magnesium compound such as those represented by the following formulas (II): n and (IV): n represented by the following formula (III): n n n MgR 5 R 6   (III) n n n wherein R 5 represents a C 1-12 alkyl group, a C 2-5 alkenyl group, a 5- to 8-membered alicyclic group which may be substituted by a lower C 1-4 alkyl group, a phenyl group which may be substituted by a lower C 1-4 alkyl group, a lower C 1-4 alkoxy group or a halogen atom or a benzyl group which may be substituted by a lower C 1-4 alkyl group, a lower C 1-4 alkoxy group or a halogen atom, and R 6 represents a halogen atom, a methanesulfonyloxy group, a benzenesulfonyloxy group, a p-toluenesulfonyloxy group, a trifluoromethanesulfonyloxy group, an acetoxy group which may be substituted by a halogen atom or a cyano group or an OR 7 group (R 7 representing a lower C 1-4 alkyl group, a substituted or unsubstituted phenyl group or a substituted or unsubstituted benzyl group). The process provides an industrially excellent process for the preparation of a 4-substituted azetidinone derivative which permits the selective preparation of an intermediate for the synthesis of a carbapenem antibacterial agent having a desired 1-β′ configuration.

专利号:US-4740627-A
优先权日:1987-05-21
标题:Synthesis of E,Z-11-tetradecen-1-al
发明人：BYERS JIM D; DRAKE CHARLES A
权利人:PHILLIPS PETROLEUM CO
摘要:The present invention pertains to a process for making a E,Z-11-tetradecen-1-al containing from 80 to 83 mole percent of the E isomer and from 17 to 20 mole percent of the Z isomer which exhibits pheromone-like activity for the spruce bud worm (choristoneura fumiferana).

专利号:US-8487108-B2
优先权日:2005-11-14
标题 :Piperidinyl carbamate intermediates for the synthesis of aspartic protease inhibitors
发明人：BALDWIN JOHN J; CLAREMON DAVID A; TICE COLIN; CACATIAN SALVACION; DILLARD LAWRENCE W; ISHCHENKO ALEXEY V; YUAN JING; XU ZHENRONG; MCGEEHAN GERARD; SIMPSON ROBERT D; SINGH SURESH B; ZHAO WEI; FLAHERTY PATRICK T
权利人:BALDWIN JOHN J; CLAREMON DAVID A; TICE COLIN; CACATIAN SALVACION; DILLARD LAWRENCE W; ISHCHENKO ALEXEY V; YUAN JING; XU ZHENRONG; MCGEEHAN GERARD; SIMPSON ROBERT D; SINGH SURESH B; ZHAO WEI; FLAHERTY PATRICK T; VITAE PHARMACEUTICALS INC
摘要:The present invention is directed to aspartic protease inhibitors. Certain aspartic protease inhibitors of the invention can be represented by the following structural formula or a pharmaceutically acceptable salt thereof. The present invention is also directed to pharmaceutical compositions comprising the disclosed aspartic protease inhibitors. The present invention is further directed to methods of antagonizing one or more aspartic proteases in a subject in need thereof, and methods for treating an aspartic protease mediated disorder in a subject using the disclosed aspartic protease inhibitors.

专利号:US-9663594-B2
优先权日:2014-05-15
标 题 :Synthesis of aryl coupled bis phenoxides and their use in olefin polymerization catalyst systems with activator-supports
发明人：HLAVINKA MARK L
权利人:CHEVRON PHILLIPS CHEMICAL CO LP; CHEVRON PHILIPS CHEMICAL COMPANY LP
摘要:Disclosed herein are methods of making bis(phenol) ligand compounds and transition metal bis(phenolate) compounds. The transition metal bis(phenolate) compounds can be used as components in catalyst systems for the polymerization of olefins.