专利号:US-8653223-B2 优先权日:2008-04-16 标题:Transketalized compositions, synthesis, and applications 发明人:SELIFONOV SERGEY; GOETZ ADAM EDWARD; JING FENG 权利人:SELIFONOV SERGEY; GOETZ ADAM EDWARD; JING FENG; SEGETIS INC 摘要:Ketal compounds of the structure I n nand a method of preparation of the compound from polyols and oxocarboxylates, as well as uses thereof.
专利号:US-8546519-B2 优先权日:2007-10-09 标题 :Polyketal compounds, synthesis, and applications 发明人:SELIFONOV SERGEY; ROTHSTEIN SCOTT D; WICKS DOUGLAS A; MULLEN BRIAN D; MULLEN TARA J; PRATT JASON D; WILLIAMS CHARLES T; WU CHUNYONG; ZHOU NING 权利人:SELIFONOV SERGEY; ROTHSTEIN SCOTT D; WICKS DOUGLAS A; MULLEN BRIAN D; MULLEN TARA J; PRATT JASON D; WILLIAMS CHARLES T; WU CHUNYONG; ZHOU NING; SEGETIS INC 摘要:The invention relates to polyketal compounds. The compounds are synthesized by the selective ketalization of oxocarboxylic acids, e.g. keto acids and semialdehydes, and esters thereof with tetrols and higher polyols that products two or more cyclic ketal ester moieties per molecule, wherein the cyclic ketal moieties are situated in a bis-, tris-, or polyketal conformation. The invention further relates to applications of these compounds and subsequent reactions thereof.
专利号:US-2008119483-A1 优先权日:2006-08-18 标题:Compositions and methods for inhibiting protozoan growth 发明人:BEVERLEY STEPHEN M; ZHANG KAI 权利人:UNIV ST LOUIS 摘要:The present invention provides compositions and methods for inhibiting protozoan growth comprising a synergistic combination of lipid synthesis inhibitors. In addition, the invention provides compositions and methods that are useful for the treatment of protozoan infections and the identification of potential new drugs for the treatment of protozoan infections.
专利号:CN-106008419-B 优先权日:2016-06-15 标题 :Synthesis process of tetronic acid
1: Onodera T, Momose I, Adachi H, Yamazaki Y, Sawa R, Ohba SI, Kawada M. Human pancreatic cancer cells under nutrient deprivation are vulnerable to redox system inhibition. J Biol Chem. 2020 Sep 25:jbc.RA120.013893. doi: 10.1074/jbc.RA120.013893. Epub ahead of print. 21(11):1391-1404. doi: 10.1111/mpp.12990. Epub 2020 Sep 23. 3: Hu HC, Li CY, Tsai YH, Yang DY, Wu YC, Hwang TL, Chen SL, Fülöp F, Hunyadi A, Yen CH, Cheng YB, Chang FR. Secondary Metabolites and Bioactivities of Aspergillus ochraceopetaliformis Isolated from Anthurium brownii. ACS Omega. 2020 Aug 14;5(33):20991-20999. doi: 10.1021/acsomega.0c02489.
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