CAS: 776-86-3; 6-Hydroxy-7-Methoxy-2H-Chromen-2-One
该化合物是一种自然形成的科马林衍生物,因其具有生物活性植物化学作用而得到承认. 它具有显著的抗氧化剂,抗炎和潜在的抗癌特性,使其在药理学和生化学研究中具有价值. 其结构上与氯摩丁相似,异丙醇因其氢氧化物组群定位而有所区别,影响其反应性和溶解性. 它调节酶活动和与细胞路径互动的能力强调了其在研究氧化性压力和炎热反应方面的效用. 高纯度和稳定性,异氯酚在包括HPLC和LC-MS在内的分析应用中成为可靠的参考标准. 它在研究应用中的多功能突出其在学术和工业环境中的重要性.
- 英文名称6-Hydroxy-7-Methoxy-2H-Chromen-2-One
- 中文名称异莨菪亭
- IUPAC名称6-hydroxy-7-methoxy-2H-chromen-2-one
- 其它别名2H-1-Benzopyran-2-One, 6-Hydroxy-7-Methoxy-; 7-Methoxyesculetin; 6-Hydrox
- CAS编号776-86-3
- MFCD编号:MFCD00016976
- EINECS号:212-282-4
- 分子式:C10H8O4分子量:192.17
- 产品CID: 1771194
- 产品分类原料药 → 呼吸系统用药 → 平喘药
物理性质
- 熔点206-208 °C
- 沸点413.5±45.0 °C at 760 mmHg
- 闪点172.4±22.2 °C
- 密度1.4±0.1 g/cm3
- pKa:8.94±0.20(预测)
- PSA:59.67
- LogP:0.83
- 折射率1.609
- 蒸汽压0.0±1.0 mmHg at 25°C
- 溶解性DMSO: Soluble
- 外观形态浅米色至浅米色固体
- 储存条件密封干燥,2-8°C
- 产品应用该化合物用作治疗慢性支气管炎和支气气管哮喘;此外,它通过缓解心肌缺血症和预防心律不全,显示出对心血管保护的效果;它还显示出对人体CCRF-CEM白血病细胞和多抗药性子线CEM/ADR5000的人体乙型乙型丙型乙酰乙型六氯环己烷复制和重大抗刺激活动有强烈的抑制作用.
MSDS等安全信息
上下游产品
diazomethane aesculetin 7-methoxycoumarin 6-acetoxy-7-methoxy-chromen-2-one 6-(3,3-dimethylallyloxy)-7-methoxycoumarin Scoparone aesculetin 5-Formyl-6-hydroxy-7-methoxycoumarin合成工艺路线路线简述
📜6-Isopropoxy-7-Methoxycoumarin置于硫酸体系中,用 溶剂黄146 作为反应溶剂,化学反应 2.5H,以96.5%的收率获得产物异莨菪亭
参考文献:Synthetic Studies On Naturally occurring Coumarins. Ii. Synthesis Of 6,7-Dimethoxy-And 7,8-Dimethoxy-5-((E)-3-Oxo-1-Butenyl)Coumarins.
标题:Synthetic Studies On Naturally occurring Coumarins. Ii. Synthesis Of 6,7-Dimethoxy-And 7,8-Dimethoxy-5-((E)-3-Oxo-1-Butenyl)Coumarins.
摘要:关于从亚洲假黄檗(Toddalia Asiatica)中分离出的所谓reisch香豆素的结构鉴定研究,通过图表2和图表3所示的路线分别完成了两种香豆素(4和5)的合成.表i给出了合成的香豆素(4和5)以及相关香豆素(5-甲氧基苏贝瑞酮,托达来酮和reisch香豆素)的熔点和核磁共振数据,这表明所谓的reisch香豆素可能是化合物4.
DOI:10.1248/cpb.40.2614
海关参考信息
- 2905110000-甲醇
2907210001-间苯二酚
2908199090-其他酚的卤化衍生物
2908999090-其他酚的硝化衍生物 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:WO-2023156270-A1
优先权日:2022-02-18
标题:Coumarin synthesis and uses thereof
发明人：CONRATH UWE; LANGENBACH CASPAR; BEYER SEBASTIAN FELIX; SCHWINGES PATRICK; SCHULTHEISS HOLGER; BEESLEY ALEXANDER; LINKE CEDRIC
权利人:BASF SE; RWTH AACHEN
摘要:The present invention relates to genes, materials and methods for coumarin synthesis and the application thereof for improving plant health, preferably against infection by phythopathogenic microorganisms, and/or for improving plant health against coumarin-induced adverse effects on plant health. Furthermore, the invention pertains to methods and uses of such genes and mate- rials for creating correspondingly beneficial plant cells, plant parts and whole plants, and relates to products obtained from such plants or plant parts.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Chang HC, Wang SW, Chen CY, Hwang TL, Cheng MJ, Sung PJ, Liao KW, Chen JJ. Secoiridoid Glucosides and Anti-Inflammatory Constituents from the Stem Bark of Fraxinus chinensis. Molecules. 2020 Dec 14;25(24):5911. doi: 10.3390/molecules25245911.
2: Hui Y, Wang X, Yu Z, Fan X, Cui B, Zhao T, Mao L, Feng H, Lin L, Yu Q, Zhang J, Wang B, Chen X, Zhao X, Sun C. Scoparone as a therapeutic drug in liver diseases: Pharmacology, pharmacokinetics and molecular mechanisms of action. Pharmacol Res. 2020 Oct;160:105170. doi: 10.1016/j.phrs.2020.105170. Epub 2020 Aug 30. 24(3):619. doi: 10.3390/molecules24030619.
5: Juvonen RO, Novák F, Emmanouilidou E, Auriola S, Timonen J, Heikkinen AT, Küblbeck J, Finel M, Raunio H. Metabolism of Scoparone in Experimental Animals and Humans. Planta Med. 2019 Apr;85(6):453-464. doi: 10.1055/a-0835-2301. Epub 2019 Feb 8. 43(8):513-520. doi: 10.2131/jts.43.513.
合成参考文献
参考文献:10.1016/j.carres.2011.04.028
摘要:Zhao YX, Liang WJ, Fan HJ, Ma QY, Tian WX, Dai HF, Jiang HZ, Li N, Ma XF. Fatty acid synthase inhibitors from the hulls of Nephelium lappaceum L. Carbohydr Res. 2011 Aug 16;346(11):1302–6. doi: 10.1016/j.carres.2011.04.028.
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