CAS: 597-52-4; Triethylsilanol

该化合物是有机硅化合物,其特点是存在三乙基组和氢氧基组的硅原子,其分子式为C6H16OSi,表明其含有碳,氢,氧和硅.三乙基西拉诺醇通常是一种无色液体,具有温味的气味,以其在有机溶剂中的溶解性而闻名,同时又在水中不易溶解.这种化合物显示出硅醇化合物的典型特性,包括因氢氧化合物组而形成氢结的能力,这可能影响其再活动及与其他物质的相互作用.三乙基西兰诺醇经常被用作各种硅化合物合成的前体,并作为有机合成的试剂.此外,它可以作为材料科学中的表面修饰剂和制剂中的一种潜在添加剂,需要增加水的耐耐性或粘合性.在处理该化合物时,应当注意安全防范,因为与皮肤或眼睛接触时可能会引起刺激.

结构式图片

相似化合物

2117-34-2 994-49-0 17877-23-5

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号617-86-7 三乙基硅烷 | CAS号994-30-9 三乙基氯硅烷 | CAS号853348-88-6 1-(4-bromo-phen... | CAS号18056-07-0 Bis[triethylsil... | CAS号1631-33-0 三乙基(硅烷-d) | CAS号18754-93-3 triethyl-triphe... | CAS号805242-49-3 ((1,1-difluoroe... | CAS号10028-15-6 臭氧 | CAS号111662-20-5 1,3,2-dioxaphos... | CAS号14629-52-8 Triethylpentoxy... | CAS号17957-36-7 triethyl(°Ctoxy... | CAS号994-49-0 六乙基二硅氧烷 | CAS号115-11-7 2-甲基丙烯 | CAS号1016592-87-2 1,1,1-triethyl-... | CAS号63620-14-4 3-triethylsilyl... | CAS号994-30-9 三乙基氯硅烷 | CAS号5290-29-9 triethylacetoxy...

合成工艺路线路线简述

    乙氧基三乙基硅烷置于ch3Cocl,Nh3体系中,用 氨 作为反应溶剂,化学反应生成 三乙基硅烷醇
    参考文献:Ladenburg,A.,Chemische Berichte,1871,Vol. 4,P. 901-903
    标题:Ladenburg,A.,Chemische Berichte,1871,Vol. 4,P. 901-903

    海关参考信息

    专利信息


    专利号:US-8293930-B1
    优先权日:2004-06-25
    标题 :One pot synthesis of taxane derivatives and their conversion to paclitaxel and docetaxel
    发明人:NAIDU RAGINA
    权利人:NAIDU RAGINA; CHATHAM BIOTEC LTD
    摘要:A process is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel, in particular, the semi-synthesis of protected taxane intermediate in a one pot reaction of protecting the C-7 and C-10 positions and attaching a side chain at the C-13 position and subsequently deprotecting the group to form paclitaxel or docetaxel, and taxane intermediates.

    专利号:US-7893283-B2
    优先权日:2004-06-04
    标题:Semi-synthesis of taxane intermediates and their conversion to paclitaxel and docetaxel
    发明人:NAIDU RAGINA
    权利人:CHATHAM BIOTEC LTD
    摘要:A process is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel, in particular, the semi-synthesis of protected taxane intermediates.

    专利号:US-2017327504-A1
    优先权日:2014-10-30
    标 题:Synthesis of Substituted 1H-Pyrazolo[3,4-D]Pyrimidines
    发明人:ROSE CHRISTOPHER; SILBERGER HERBERT; SCHREINER ERWIN; FELZMANN WOLFGANG; MARAS NENAD
    权利人:SANDOZ AG
    摘要:The present invention refers to the synthesis and intermediates of substituted bicyclic compounds by using a central 1H-pyrazolo[3,4-d]pyrimidine of formula (I), which is assembled starting from 4,6-dichloropyrimidine carboxylic acid. The invention in particular refers to the synthesis of the Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one(ibrutinib) and its synthesis intermediates.

    专利号:US-10730904-B2
    优先权日:2012-11-14
    标 题:Method for liquid-phase synthesis of nucleic acid
    发明人:NONOGAWA MITSURU; NAGATA TOSHIAKI; SAITO HIDEKI; YASUMA TSUNEO
    权利人:TAKEDA PHARMACEUTICALS CO
    摘要:In this method, an oligonucleotide represented by formula (II) [wherein Y 1 , Q, Base, r and r′ are each as defined in claim 1 ] is prepared by using, as a synthesis unit, a novel nucleoside monomer compound represented by formula (I) [wherein X, R 1 , Y, Base, Z, Ar, R 2 , R 3 and n are each as defined in claim 1 ]. The novel nucleoside monomer compound is a nucleoside, the base moiety of which is substituted with an aromatic-hydrocarbon-ring-carbonyl or -thiocarbonyl group having at least one hydrophobic group. The method can dispense with column-chromatographic purification in every reaction, and enables base elongation not only in the 3′-direction but also in the 5′-direction, thus attaining efficient liquid-phase mass synthesis of an oligonucleotide.

    专利号:US-2005192445-A1
    优先权日:2004-03-01
    标题:Semi-synthesis of taxane intermediates and aziridine analogues and their conversion to paclitaxel and docetaxel
    发明人:NAIDU RAGINA
    权利人:PHYTOGEN LIFE SCIENCES INC
    摘要:A process is provided for the semi-synthesis of taxane intermediates and aziridine analogues of cephalomannne and baccatin III intermediates, and the conversion of such intermediates and analogues to paclitaxel and docetaxel.

    专利号:US-9994508-B2
    优先权日:2012-12-11
    标 题:Versatile and functionalised intermediates for the synthesis of vitamin D and novel vitamin D derivatives
    发明人:LOPEZ PEREZ BORJA; SIGUEIRO PONTE RITA; MAESTRO SAAVEDRA MIGUEL A; MOURINO MOSQUERA ANTONIO
    权利人:ENDOTHERM GMBH
    摘要:Novel intermediates for the complete synthesis of vitamin D are provided that allow a great versatility of functional groups in the final vitamin derivatives. Vitamin derivatives that are epimeric in position 3 and vitamin derivatives with a wide range of functionalities in position 18, including compounds with isotopic labelling are provided.
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    合成参考文献


    摘要:Hardman-Baldwin, A. M.; Mattson, A. E., Science of Synthesis Knowledge Updates, (2017) 1, 217.
    摘要:Hardman-Baldwin, A. M.; Mattson, A. E., Science of Synthesis Knowledge Updates, (2017) 1, 218.
    摘要:Hardman-Baldwin, A. M.; Mattson, A. E., Science of Synthesis Knowledge Updates, (2017) 1, 216.
    摘要:Hardman-Baldwin, A. M.; Mattson, A. E., Science of Synthesis Knowledge Updates, (2017) 1, 230.
    摘要:Hardman-Baldwin, A. M.; Mattson, A. E., Science of Synthesis Knowledge Updates, (2017) 1, 223.
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