CAS: 399-88-2; 3-Fluoro-4-Methylpyridine

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1196156-81-6 40273-47-0 113770-88-0

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CAS号372-47-4 3-氟吡啶 | CAS号74-88-4 碘甲烷 | CAS号3430-27-1 3-氨基-4-甲基吡啶 | CAS号23056-33-9 2-氯-4-甲基-5-硝基吡啶 | CAS号21901-41-7 2-羟基-4-甲基-5-硝基吡啶 | CAS号21901-40-6 2-氨基-4-甲基-5-硝基吡啶 | CAS号6635-86-5 2-氨基-4-甲基-3-硝基吡啶 | CAS号21901-18-8 2-羟基-4-甲基-3-硝基吡啶 | CAS号23056-39-5 2-氯-4-甲基-3-硝基吡啶 | CAS号695-34-1 2-氨基-4-甲基吡啶 | CAS号393-53-3 3-氟吡啶-4-羧酸 | CAS号40273-47-0 3-氟吡啶-4-甲醛 | CAS号343-72-6 3-氟-异烟酸乙酯 | CAS号312904-99-7 2-Pyridinecarbo...

2-氯-5-硝基-4-甲基吡啶置于palladium On Activated Charcoal,亚硝酸乙酯,Sodium Acetate,溶剂黄146,Petroleum Ether体系中,化学反应生成3-氟-4-甲基吡啶
参考文献:The Preparation Of 3-Fluoroisonicotinic Acid And Related Compounds
标题:The Preparation Of 3-Fluoroisonicotinic Acid And Related Compounds
摘要:
Doi:10.1021/jo01364A020

专利信息

专利号:US-8338451-B2
优先权日:2008-03-21
标 题 :Polysubstituted derivatives of 2-heteroaryl-6-phenylimidazo[1,2-a]pyridines, and preparation and therapeutic use thereof
发明人：DE PERETTI DANIELLE; EVANNO YANNICK; LARDENOIS PATRICK; MACHNIK DAVID; RAKOTOARISOA NATHALIE; ALMARIO GARCIA ANTONIO
权利人:DE PERETTI DANIELLE; EVANNO YANNICK; LARDENOIS PATRICK; MACHNIK DAVID; RAKOTOARISOA NATHALIE; ALMARIO GARCIA ANTONIO; SANOFI SA
摘要:Compounds of formula (I): n nwherein R, R 1 , R 2 , R 3 , R 4 and X are as defined in the disclosure, or an acid addition salt thereof, and the therapeutic use and process of synthesis thereof.

专利号:US-8362019-B2
优先权日:2008-02-01
标 题:Synthesis and anti-proliferative effect of substituted imidazo[4,5-b]pyrazine compounds
发明人：WINFIELD LEYTE L
权利人:SPELMAN COLLEGE; WINFIELD LEYTE L
摘要:This invention provides for compounds, compositions, and methods that involve anti-proliferative and anti-neoplastic activity in cancer cells. In particular, a series of benzimidazole, purine, imidazopyridine, and imidazopyrizine compounds having selected substitution patterns are disclosed, and the activity of various subject compounds is demonstrated. In particular, the disclosure provides for substituted imidazo[4,5-b]pyrazine compounds having the general formula n ntheir salts, pharmaceutical compositions, and methods of treatment using the subject compounds and compositions.

专利号:US-2012095038-A1
优先权日:2008-02-01
标 题:Synthesis and anti-proliferative effect of benzimidazole derivatives

专利号:WO-2014158302-A1
优先权日:2013-03-25
标 题:Novel sphingosine 1-phosphate receptor antagonists
发明人：SWENSON ROLF ERIC
权利人:SWENSON ROLF ERIC
摘要:The present invention relates to sphingosine-1 -phosphate (S1 P) receptors and compounds of the general formula (1), that are useful in the treatment and prevention of conditions associated with such receptors. More specifically, the present invention relates to the synthesis and use of sphingosine 1 -phosphate receptor 2 (S1 P2) antagonists that are useful in the treatment of cancer, atherosclerosis, diabetic retinopathy, and other inflammatory diseases. Among these inflammatory diseases that could be treated with these S1 P2 antagonist are those characterized by fibrosis including chronic lung disease, chronic kidney and liver disease, chronic heart disease, and skin diseases such as sclerosis/scleroderma. The S1 P2 antagonists can also be used in the treatment of glioblastoma multiforme (brain cancer), pediatric neuroblastoma, and other cancers.

专利号:US-8536164-B2
优先权日:2010-12-20
标 题:Fused pyridine compounds as casein kinase inhibitors
发明人：BUTLER TODD W; CHANDRASEKARAN RAMALAKSHMI Y; MENTE SCOT R; SUBRAMANYAM CHAKRAPANI; WAGER TRAVIS T
权利人:BUTLER TODD W; CHANDRASEKARAN RAMALAKSHMI Y; MENTE SCOT R; SUBRAMANYAM CHAKRAPANI; WAGER TRAVIS T; PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: n nand pharmaceutically acceptable salts thereof, wherein X, Y, A, R 4 , n, and R 7 are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:US-2012095009-A1
优先权日:2008-02-01
标题 :Synthesis and anti-proliferative effect of benzimidazole derivatives