CAS: 343306-71-8; 6A,6B,6C,6D,6E,6F,6G,6H-Octakis-S-(2-Carboxyethyl)-6A,6B,6C,6D,6E,6F,6G,6H-Octathio-?-Cyclodextrin
该化合物是一种经过修改的伽西-环己二异丙烯衍生物,由八种硫醚-连通的carboxy乙基组组成.这种结构改变增强了其溶性与稳定性,同时保留了环球exclydrins所固有的宿主-客人复杂特性.引入的碳箱型组提供了其他功能化点,使之适合药物交付,分子识别和超分子化学的应用.它的多硫醚联系确保了强大的化学抗药性,而碳箱基穆埃能够进一步凝固或pH-反应行为.这种衍生物对于建立定制的纳米载体或高级材料设计具有特别价值,提供精确的分子相互作用.
- 英文名称6A,6B,6C,6D,6E,6F,6G,6H-Octakis-S-(2-Carboxyethyl)-6A,6B,6C,6D,6E,6F,6G,6H-Octathio-?-Cyclodextrin
- 中文名称舒更葡糖钠
- IUPAC名称6A,6B,6C,6D,6E,6F,6G,6H-octakis-S-(2-Carboxyethyl)-6A,6B,6C,6D,6E,6F,6G,6H-octathio-γ-cyclodextrin
- 其它别名Shu Glucose; Sugammadex; Sugammadex [inn]; Sugammadex Sodium; Sugammagex; Bridion
- CAS编号343306-71-8
- MFCD编号:MFCD09954145
- FDA UNII编号:361LPM2T56
- 分子式:C72H112O48S8分子量:2002.18
- 产品CID: 1345178
- 同类组份化合物CAS343306-71-8 (free form)343306-79-6 (sodium)
- 产品分类原料药 → 神经系统用药
物理性质
合成工艺路线路线简述
📜3-巯基丙酸置于sodium Methylate体系中,化学反应生成 舒更葡糖
参考文献:An Improved Process For The Preparation Of Sugammadex
标题:An Improved Process For The Preparation Of Sugammadex
摘要:本申请提供了一种改进的方法,通过在适宜的有机溶剂中将3-巯基丙酸盐与6-去氧-6-卤代-γ-环糊精反应,制备sugammadex.本申请还提供了3-巯基丙酸盐的晶体形式,优选为3-巯基丙酸二钠盐,以及其用于制备sugammadex.式(i)显示了sugammadex的钠盐.
专利信息
专利号:US-9120876-B2
优先权日:2010-08-25
标 题 :Process for preparation of Sugammadex
发明人：DAVULURI RAMAMOHAN RAO; PONNAIAH RAVI; SRIBHASHYAM RAVI KANTH; VALSAN NANDKUMAR MECHERILI; DONGARI NARESH; CHLNV PRASAD; BATTHINI GURUSWAMY
权利人:DAVULURI RAMAMOHAN RAO; PONNAIAH RAVI; SRIBHASHYAM RAVI KANTH; VALSAN NANDKUMAR MECHERILI; DONGARI NARESH; CHLNV PRASAD; BATTHINI GURUSWAMY
摘要:A novel process for the preparation of 6-perdeoxy-6-per-halo Gamma cyclodextrin which is a useful intermediate in the synthesis of Sugammadex is disclosed in the invention. The process involves reacting Gamma cyclodextrin with phosphorous halide in the presence of organic solvent.
专利号:ES-2948930-T3
优先权日:2017-11-27
标题 :Process for the synthesis of a cyclodextrin derivative
专利号:JP-7460521-B2
优先权日:2017-11-27
标题:Method for the synthesis of cyclodextrin derivatives
专利号:US-2020377621-A1
优先权日:2017-11-27
标题 :Process for the synthesis of a cyclodextrin derivative
专利号:CN-111320712-A
优先权日:2020-04-09
标 题 :Synthesis method of sugammadex sodium intramolecular thioether impurity
专利号:CN-111471121-A
优先权日:2020-04-10
标题 :Synthesis method of sugammadex dimer impurity
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Radkowski P, Derkaczew MA, Jacewicz MA, Onichimowski D. The Dosage of Muscle Relaxants in Morbidly Obese Patients in Daily Practice - A Narrative Review. Int J Gen Med. 2024 Sep 14;17:4055-4060. doi: 10.2147/IJGM.S474221.
2: Postaci A, Durgut R, Aytac BG, Ceyhan M. Effect of sugammadex with neostigmine on postoperative bowel function and on recovery of neuromuscular functions: A randomized controlled trial. Medicine (Baltimore). 2024 Sep 13;103(37):e39623. doi: 10.1097/MD.0000000000039623.
3: Wang Y, Qu Y, Jiang Y, Li Z, Hou X, Yang L, Zhao L, Xiong X, Xu M. Magnetic solid-phase extraction coupled with LC-MS/MS methods for the simple extraction and rapid determination of sugammadex in human plasma. Anal Methods. 2024 Sep 16. doi: 10.1039/d4ay01185f. Epub ahead of print. 13(17):5083. doi: 10.3390/jcm13175083.
合成参考文献
参考文献:10.1007/s12630-011-9554-y
摘要:Le Corre F, Nejmeddine S, Fatahine C, Tayar C, Marty J, Plaud B. Recurarization after sugammadex reversal in an obese patient. Journal canadien d'anesthésie. 2011 Jul 13;58(10):944. doi: 10.1007/s12630-011-9554-y.
参考文献:10.1093/bja/aer211
摘要:Funnell AE, Griffiths J, Hodzovic I. A further case of rocuronium-induced anaphylaxis treated with sugammadex. British Journal of Anaesthesia. 2011 Aug;107(2):275–6. doi: 10.1093/bja/aer211.
摘要:Øberg E, Claudius C. [Possible clinical potential in reverting muscular block with sugammadex in anaesthesia and surgery]. Ugeskr Laeger. 2013 Feb 11;175(7):428–32.
📝 需求与反馈
尽可能描述清楚需求与问题信息
