专利号:WO-2013008247-A1 优先权日:2011-07-13 标题:Process for preparation of (dl) -norepinephrine acid addition salt, a key intermediate of (r) - (-) - norepinephrine 发明人:DALVI MAHESH BHAGOJI; KENNY RAJESH SHASHIKANT; KAWLE GANESH RAMACHANDRA 权利人:NEON LAB LTD; DALVI MAHESH BHAGOJI; KENNY RAJESH SHASHIKANT; KAWLE GANESH RAMACHANDRA 摘要:The invention discloses a process for preparation of (dl)-norepinephrine salt by reacting 3,4-dihydroxy-a-haloacetophenone with hexamethylenetetramine to provide hexamine salt; followed by hydrolysis and hydrogenation. The invention also discloses a novel intermediate formed in the process and its synthesis.
专利号:US-9067934-B2 优先权日:2011-03-31 标题 :Bicyclic pyridinones 发明人:PETTERSSON MARTIN YOUNGJIN; JOHNSON DOUGLAS SCOTT; SUBRAMANYAM CHAKRAPANI; O'DONNELL CHRISTOPHER JOHN; AM ENDE CHRISTOPHER WILLIAM; FISH BENJAMIN ADAM; GREEN MICHAEL ERIC; MULLINS PATRICK BRADLEY; STIFF CORY MICHAEL; TRAN TUAN PHONG; NAVARATNAM THAYALAN 权利人:PFIZER 摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n nas defined herein. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
摘要:Acute Toxicity Data. Journal of the American College of Toxicology, Part B., 1(183), 1992 摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2003).