专利号:US-10202620-B2 优先权日:2014-05-16 标 题:Synthesis of olefinic alcohols via enzymatic terminal hydroxylation 发明人:COELHO PEDRO; CHEN MIKE M Y; MEINHOLD PETER; CHO CATHERINE MEE-HIE; BUI VU; HEEL THOMAS 权利人:PROVIVI INC 摘要:In certain aspects, the present invention provides methods for producing terminally hydroxylated alkenes and alkynes by contacting an unsaturated or saturated hydrocarbon substrate with a hydroxylase enzyme. Exemplary terminal hydroxylases useful for carrying out the methods of the invention exhibit strong selectivity towards one terminal carbon of a hydrocarbon substrate and include, but are not limited to, non-heme diiron alkane monooxygenases, cytochromes P450 (e.g., cytochromes P450 of the CYP52 and CYP153 family), as well as long chain alkane hydroxylases. In some embodiments, the terminally hydroxylated alkene or alkyne is further converted to a terminal alkenal. In certain embodiments, terminally hydroxylated alkenes and alkynes are useful as insect pheromones which modify insect behavior. In other embodiments, terminally hydroxylated alkenes and alkynes are useful intermediates for producing pheromones via acetylation or oxidation of the alcohol moiety.
专利号:US-4228093-A 优先权日:1979-10-18 标 题:(11Z,13Z)-11,13-Hexadecadiyn-1-ol and (11Z,13Z)-11,13-hexadecadien-1-ol and trimethylsilyl ethers thereof 发明人:CARNEY ROBERT L; HENRICK CLIVE A 权利人:ZOECON CORP 摘要:Synthesis of an attractant (11Z,13Z)-11,13-hexadecadienal for the navel orangeworm Amyelois transitella, and intermediates therefor.
专利号:US-2016108436-A1 优先权日:2014-05-16 标题:Synthesis of olefinic alcohols via enzymatic terminal hydroxylation
专利号:WO-2015176020-A1 优先权日:2014-05-16 标题 :Synthesis of olefinic alcohols via enzymatic terminal hydroxylation