CAS: 16744-98-2; 2-Fluorophenylisocyanate

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59025-55-7 1195-45-5 1360960-48-0

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2-Fluoroaniline bis(trichloromethyl) carbonate phosgene 1-chloro-2-fluorobenzene 4-[(2-fluoro-phenylcarbamoyloxy)-methyl]-4-methyl-oxazolidine-2-thione (2-Fluoro-phenyl)-carbamic acid 2-piperidin-1-yl-ethyl ester; hydr°Chloride 1-(2-fluoro-phenyl)-3-(5-trifluoromethyl-[1,3,4]thiadiazol-2-yl)-urea 1,2-Diaza-bicyclo[2.2.2]°Ctane-2-carboxylic acid (2-fluoro-phenyl)-amide

2-氟苯胺置于硫酸体系中,用 甲苯 用作溶剂,化学反应 2.0H,反应生成2-氟苯基异氰酸酯
参考文献:Organosilicon Synthesis Of Isocyanates: I. Synthesis Of Isocyanates Of The Furan,Thiophene,And Mono-And Polyfluorophenyl Series
标题:Organosilicon Synthesis Of Isocyanates: I. Synthesis Of Isocyanates Of The Furan,Thiophene,And Mono-And Polyfluorophenyl Series
摘要:A Convenient Synthesis Of Known And Unknown Isocyanates Of The Furan,Thiophene,And Mono-And Polyfluorophenyl Series,Involving Silylation Of Starting Amines With Hexamethyldisilazane Or Chlorotrimethylsilane,Followed By Phosgenation Of The Resulting N-Silyl-Substituted Amines. An Unusual High-Temperature Rearrangement Of 3-(Methoxycarbonyl)-4,5-Dimethylthiophene-2-Yl Isocyanate Into Its 5-Ethyl Isomer. Ortho-Fluorine Substituent In Anilines Decreases The Yield Of Isocyanates,Whereas 2,3,5,6-Tetrafluorophenyl Isocyanate Exists For Only A Short Time As A 5% Toluene Solution.
Doi:10.1134/s1070363206010208

专利信息

专利号:US-2005192265-A1
优先权日:2003-03-20
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6906056-B2
优先权日:1998-06-22
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
权利人:LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6054464-A
优先权日:1996-02-23
标题:Azabicyclic esters of carbamic acids useful in therapy
发明人：MACOR JOHN; WU EDWIN
权利人:ASTRA AB
摘要:A compound of formula ##STR1## X is O or S; Y is O or S; G and D are independently nitrogen or carbon with the proviso that no more than one of G, D, or E is nitrogen; E is N or C--R 4 ; R 1 is hydrogen or methyl; R 2 is hydrogen or fluoro; R 3 is hydrogen, halogen, C 1 to C 3 alkyl, --OR 5 , --CN, --CONH 2 , --CO 2 R 5 , --NR 5 R 6 or phenyl optionally substituted with one to three of the following substituents: halogen, C 1 to C 3 alkyl, --NO 2 , --CN, or --OCH 3 ; R 4 is hydrogen, halogen, C 1 to C 3 alkyl, --OR 5 , --CN, --CONH 2 , --CO 2 R 5 , --NR 5 R 6 or phenyl optionally substituted with one to three of the following substituents: halogen, C 1 to C 3 alkyl, --NO 2 , --CN, or --OCH 3 ; n or R 2 and R 3 or R 3 and R 4 may together represent a fused phenyl ring optionally substituted with one or two of the following substituents: halogen, C 1 to C 3 alkyl, --NO 2 , --CN, or --OCH 3 ; R 5 and R 6 are independently hydrogen or C 1 to C 3 alkyl; n or an enantiomer thereof, and pharmaceutically acceptable salts thereof, processes for preparing the, compositions containing them, and their use in therapy, especially in the treatment or prophylaxis of psychotic disorders and intellectual impairment disorders, as well as intermediates and use of intermediates in synthesis.

专利号:US-10570179-B2
优先权日:2016-09-02
标 题:Substituted urea depsipeptide analogs as activators of the CLPP endopeptidase
发明人：LEE RICHARD E; ZHAO YING
权利人:ST JUDE CHILDRENS RES HOSPITAL
摘要:In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators the ClpP endopeptidease; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating infectious disease using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-11807596-B2
优先权日:2017-10-26
标题:Thiol compounds, synthesis method therefor, and utilization of said thiol compounds
发明人：OKUMURA NAOTO; OTSUKA AKIHITO; KUMANO TAKESHI; FUJIKAWA KAZUYUKI; ARAKI YUSUKE
权利人:SHIKOKU CHEM
摘要:The purpose of the present invention is to provide: novel thiol compounds; a method for synthesizing said thiol compounds; curing agents containing said thiol compounds; resin compositions containing said thiol compounds and an epoxy compound; and resin compositions containing said thiol compounds and an ene compound having a carbon-carbon double bond in a molecule. Furthermore, the purpose of the present invention is to provide adhesives and sealants having these resin compositions as ingredients. The thiol compounds of the present invention are represented by chemical formula (I) to chemical formula (VII).

专利号:US-4158672-A
优先权日:1976-01-26
标题 :Polyfluoroalkylthio alcohols, esters and useful compositions therefrom
发明人：DEAR ROBERT E A; BRACE NEAL O
权利人:CIBA GEIGY CORP
摘要:Polyfluoroalkylthio alcohols and esters thereof are disclosed with utility as intermediates for the synthesis of fluorochemicals with low free surface energies having oil and water repellent properties. The novel alcohols and esters are obtained by a free radical catalyzed addition of polyfluoroalkylthiols to acetylenic alcohols or esters thereof. The alcohols are employed in preparation of fluorine containing polyurethanes which are useful as finishes to provide oil and water repellency to textiles and as additives to plastics to provide mold release and other desirable properties.