CAS: 159858-21-6; Fmoc-Val-Cit-Oh

相似化合物

870487-08-4 142810-19-3 159858-33-0

上下游产品

Fmoc-L-缬氨酸 Fmoc-Val-Oh 68858-20-8
Fmoc-L-缬氨酸羟基琥珀酰亚胺酯 2,5-Dioxopyrrolidin-1-Yl-N-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-L-Valinate 130878-68-1
(9H-Fluoren-9-yl)Methyl {(2Rs)-1-[(2,5-Dioxopyrrolidin-1-yl)Oxy]-3-Methyl-1-Oxobutan-2-Yl}Carbamate 130878-68-1
氯甲酸-9-芴基甲酯 (Fluorenylmethoxy)Carbonyl Chloride 28920-43-6

📜L-缬氨酸置于碳酸氢钠,N,N'-二环己基碳二亚胺体系中,用 四氢呋喃,1,4-二氧六环,水,N,N-二甲基甲酰胺 用作溶剂,化学反应生成(S)-2-((S)-2-(((((9H-芴-9-基)甲氧基)羰基)氨基)-3-甲基丁酰氨基
参考文献: Compounds,Compositions,Methods,And Uses For Treating Cancer And Immunological Disorders[fr] Composés,Compositions,Méthodes Et Utilisations Pour Traiter Le Cancer Et Des Troubles Immunologiques
标题: Compounds,Compositions,Methods,And Uses For Treating Cancer And Immunological Disorders[fr] Composés,Compositions,Méthodes Et Utilisations Pour Traiter Le Cancer Et Des Troubles Immunologiques

专利信息

专利号:US-2024400608-A1
优先权日:2021-09-03
标题:Synthesis of bicycle toxin conjugates, and intermediates thereof
发明人：WITTY DAVID; LIMB DARREN; MIN BYOUNG JOON; HE LIWEN; SANDERS WILLIAM J; NNANABU ERNEST OBINNA
权利人:BRICYCLETX LTD
摘要:The present invention relates to Bicycle toxin conjugates, methods for preparation, and methods of use for treating cancer.

专利号:WO-2023031623-A2
优先权日:2021-09-03
标 题 :Synthesis of bicycle toxin conjugates, and intermediates thereof

专利号:US-2025170267-A1
优先权日:2022-02-28
标 题 :Antibody-drug conjugate precursor and intermediate for synthesis thereof
发明人：TSUZAKI YASUNORI; MIZUNO GEN; KASHIWAGI TAKAMASA; TANAKA MASAYUKI; SHIMIZU HAYATO; NONOUCHI SHIMPEI; MATSUSHITA TAKASHI; KIMURA TOMIO
权利人:UBE CORP
摘要:A method for improving the stability of an antibody-drug conjugate in a living body, and a conjugate precursor for producing a stabilized antibody-drug conjugate. An antibody-drug conjugate precursor represented by the following general formula (I) or a salt thereof, a synthetic intermediate thereof or a salt thereof, n Z-L-D  (I)n n where Z is a reactive group which can react with a functional group present in an antibody or a modified antibody; D is an antitumor drug residue in which one hydrogen atom or one hydroxy group is removed from any position of an antitumor drug molecule or an analog thereof or a derivative thereof; L is a linker which links Z to D; and at least any one of D and L has one or more lactonyl group(s) at any position(s) as substituent(s) or protecting group(s).

专利号:CN-118103075-A
优先权日:2021-09-03
标题 :Synthesis of bicyclic peptide toxin conjugates and intermediates thereof

专利号:EP-4395830-A2
优先权日:2021-09-03
标 题 :Synthesis of bicycle toxin conjugates, and intermediates thereof

专利号:CA-3229976-A1
优先权日:2021-09-03
标 题 :Synthesis of bicycle toxin conjugates, and intermediates thereof