CAS: 1583-58-0; 2,4-Difluorobenzoic Acid

上下游产品

CAS号124-38-9 二氧化碳 | CAS号2265-93-2 2,4-二氟碘苯 | CAS号364-83-0 2,4-二氟苯乙酮 | CAS号651027-06-4 2,4-difluoro-3-... | CAS号372-18-9 1,3-二氟苯 | CAS号59-88-1 盐酸苯肼 | CAS号72482-64-5 2,4-二氟苯甲酰氯 | CAS号154257-75-7 3-氯-2,4-二氟苯甲酸 | CAS号651027-02-0 (2,6-difluoroph... | CAS号13697-89-7 1,3-二氟-2-碘苯 | CAS号345-29-9 4-氟水杨酸 | CAS号65145-13-3 2-氟-4-羟基苯甲酸 | CAS号445-29-4 邻氟苯甲酸 | CAS号392-04-1 4-氟水杨酸甲酯 | CAS号185302-85-6 2’,4’-二氟苯基苯甲酰基乙酸甲酯 | CAS号28314-83-2 5-溴-2,4-二氟苯甲酸 | CAS号85118-02-1 2,4-二氟苯甲酰胺 | CAS号58101-23-8 3-(2,4-二氟苯基)-3-... | CAS号72482-64-5 2,4-二氟苯甲酰氯 | CAS号602-94-8 五氟苯甲酸

2,4-二硝基甲苯置于氯化铵,Manganese(Iv) Oxide,四丁基溴化铵,双氧水,Sodium Fluoride体系中,用 乙醇,N,N-二甲基甲酰胺 用作溶剂,化学反应 7.67H,反应生成2,4-二氟苯甲酸
参考文献:一种医药中间体2,4-二氟苯甲酸的合成方法
标题:一种医药中间体2,4-二氟苯甲酸的合成方法
摘要:本发明公开了一种医药中间体2,4‑二氟苯甲酸的合成方法,具体包括以下步骤:首先采用溶胶凝胶法制备纳米氧化硅负载的pd作为催化剂,且在制备过程中添加十六烷基三甲基氯化铵对催化剂表面进行原位修饰,然后采用2,4‑二硝基甲苯为原料,加入氯化铵以及制得的催化剂反应,收集滤液,并加入四丁基溴化铵,二氧化锰和过氧化氢反应,制得白色固体;最后以n,N‑二甲基甲酰胺,氟化钠,白色固体和四丁基溴化铵反应,得到2,4‑二氟苯甲酸.该方法操作简单,目标产物收率高.

专利信息

专利号:WO-2020248278-A1
优先权日:2019-06-14
标题:Method for continuous synthesis of substituted benzoic-acid organic substance
发明人：HONG HAO; ZHANG ENXUAN; LU JIANGPING; LIU ZHIQING; LI CHAO; TANG YANG
权利人:JINLIN ASYMCHEM LABORATORIES CO LTD
摘要:The present invention provides a method for the continuous synthesis of a substituted benzoic-acid organic substance. The continuous synthesis method comprises: in the presence of catalyst and organic solvent, the organic matter represented by formula (I) and oxygen are continuously inputted to a continuous reaction apparatus for continuous oxidation reaction to obtain a substituted benzoic-acid organic substance, which is discharged continuously, the substituted benzoic-acid organic substance having the structure represented by formula (II). Oxygen is a green reagent and is inexpensive and readily available; a large amount of wastewater, waste gas, and solid waste is not generated after the reaction, and the system is easy to handle. The use of a continuous reaction operation can reduce the risk of flash distillation and explosion of solvent due to a high concentration of oxygen in a batch reaction. Under the same oxidation conditions, the continuous preparation process can reduce the escape of oxygen, greatly increasing the oxygen utilization rate and also simplifying the operation, improving the safety of the reaction and the yield of the substituted benzoic-acid organic substance.

专利号:US-6180830-B1
优先权日:1995-11-08
标题 :Method for preparing a bimetallic ruthenium/tin catalyst and a process for the synthesis of aldehydes
发明人：JACQUOT ROLAND
权利人:RHODIA CHIMIE SA
摘要:The present invention relates to a new process for the preparation of a bimetallic ruthenium/tin catalyst. The process for the preparation of a bimetallic ruthenium/tin catalyst according to the invention is characterised by the fact that it consists in carrying out the reduction of a ruthenium complex having an electrovalency of -4 and a coordination number of 6, the ligands being either a halogen atom or an anion or a tin halide. The catalyst is further employed for the preparation of aldehydes by reduction, in the vapor phase, of carboxylic acids, esters and anhydrides.

专利号:US-4273947-A
优先权日:1979-01-31
标 题:Hydrogenation of fluorine-containing carboxylic acids
发明人：NOVOTNY MIROSLAV
权利人:ALLIED CHEM
摘要:A process is described for the heterogeneous hydrogenation of fluorine-containing alkyl, cycloalkyl, and benzene carboxylic acids to the corresponding primary alcohols. The hydrogenation can be carried out in the liquid or vapor phase in the presence of a solid rhodium or iridium catalyst, employed as the metal, metallic oxide, or mixture thereof. In the liquid phase, the hydrogenation can be carried out batchwise under mild conditions of temperature and pressure, preferably at about 50°-150° C. and about 5-15 atmospheres, in an atmosphere containing hydrogen gas. A preferred embodiment is the hydrogenation of trifluoroacetic acid in the liquid phase to 2,2,2-trifluoroethanol, said alcohol being useful as an intermediate in the synthesis of the anesthetic, isoflurane, CF 3 CHClOCHF 2 .

专利号:WO-2024054881-A1
优先权日:2022-09-07
标题:Ligand-enabled scalable c-h hydroxylation of benzoic and phenylacetic acids at room temperature
发明人：YU JIN-QUAN; LI ZHEN; PARK HAN
权利人:SCRIPPS RESEARCH INST
摘要:The application discloses industry scalable methods of using bifunctional bidentate pyridone-carboxylic acid ligands, such as 2-methyl-2-(6-oxo-1,6-dihydropyridin-2-yl)propanoic acid, that enable room-temperature Pd-catalyzed C-H hydroxylation of a broad range of benzoic and phenylacetic acids with an industry-compatible oxidant, aqueous hydrogen peroxide, at room temperature. Further disclosed are methods of derivatization of the resulting hydroxylation products, synthesis of polyfluorinated natural products coumestan or pterocarpene from phenol building blocks, and hydroxylation of ibuprofen using this methodology,

专利号:EP-2336114-B1
优先权日:2007-12-07
标题 :Process for the synthesis of l-3,4 dihydroxy-6-[18f]fluoro-phenylalanine and 2-[18f]fluor-l-tyrosine and their alpha-methylated derivatives starting from a precursor
发明人：WAGNER FRANZISKA; ERMERT JOHANNES; COENEN HEINRICH HUBERT
权利人:FORSCHUNGSZENTRUM JUELICH GMBH
摘要:Substituted benzaldehyde compounds (I), are new. Substituted benzaldehyde compounds of formula (I), is new. X : H or CH 3; R 5>nucleophilic leaving group e.g. B, F, Br, Cl, NO 2or -N(R) 3 +>; R : alkyl e.g. CH 3or C 2H 5; R 2>benzyl or methyl; and R 4>(S)-1-(tert-butoxycarbonyl)-2-tert-butyl-3-methyl-4-imidazolidinone, (S)-1-(benzoylcarbonyl)-2-tert-butyl-3-methyl-4-imidazolidinone, (S)-tert-butyl-2-tert-butyl-4-methoxy-2,5-dihydroimidazol-1-carboxylate, (2S,5R)-tert-butyl-2-tert-butyl-3,5-dimethyl-4-oxoimidazolidin-1-carboxylate, (S)-1-(benzoylcarbonyl)-2-tert-butyl-3,5-dimethyl-4-imidazolidinone or (S)-tert-butyl-2-tert-butyl-5-methyl-4-methoxy-2-hydroimidazol-1-carboxylate. Independent claims are included for: (1) the preparation of (I); and (2) preparing L-3,4-dihydroxy-6-[18F]fluorophenylalanine compound of formula (II) and 2-[18F]fluoro-L-tyrosine compound of formula (III), comprising [18F]-fluorinating (I), separating the fluorinated compound in which the fluorinated compound is oxidized to give (II) or decarbonylated to give (III), and hydrolyzing and separating the respective products. [Image] [Image].

专利号:EP-3515880-B1
优先权日:2017-03-17
标题:Methods and compositions for synthesis of encoded libraries
发明人：LI JIN; MORGAN BARRY A; Wan jinqiao; DOU DENGFENG; LIU GUANSAI; CHANG YONG; CHEN QIUXIA; WANG XING; XU YANSHAN; HU DONGYAN; LIU JIAN; CHENG XUEMIN
权利人:HITGEN INC