二苯醚置于n-溴代丁二酰亚胺(Nbs)体系中,用 乙腈 用作溶剂,以93%的收率获得4-溴联苯醚 参考文献:Synthesis Of Arylbromides From Arenes And N-Bromosuccinimide (Nbs) In Acetonitrile-A Convenient Method For Aromatic Bromination 标题:Synthesis Of Arylbromides From Arenes And N-Bromosuccinimide (Nbs) In Acetonitrile-A Convenient Method For Aromatic Bromination 摘要:利用乙腈中的 N-溴代丁二酰亚胺(nbs),可以很容易地对一系列活化的炔类化合物进行区域选择性和化学选择性亲电溴化反应.与其他亲电溴化条件相比,该方法的环境友好,底物范围大且易于合成,从而提高了其实用性. Doi:10.1139/v08-176
专利信息
专利号:EP-1454891-B1 优先权日:2003-03-07 标题 :Process for preparation of 4-(4-phenoxyphenoxy) benzoic acid by oxidation of 1-(4-methylphenoxy)-4-phenoxybenzene 发明人:GHARDA KEKI HORMUSHI; JOSEPH PULINATTU CHERIAN; JOSHI PRAKASH ACHYUT; KALYANA SUNDARAM PALLAVUR SANK 权利人:GHARDA CHEMICALS LTD 摘要:A novel process for preparation of 1-(4-methylphenoxy),4-phenoxybenzene (I) by the nucleophilic substitution route and its oxidation to give 4-(4-phenoxyphenoxy benzoic acid (II), a monomer used for synthesis of speciality thermoplastic polymer.
专利号:US-2025101021-A1 优先权日:2022-06-14 标 题:Methods of making tolebrutinib 发明人:BAILLY FRÉDÉRIC; BENELLI CHRISTOPHE; BORIE CYRIL; BOSCH MICHAËL; CABOS CLAUDE; CHARAUDEAU ALEXIS; JANSSENS LAURENCE; PACQUET FRANÇOIS; RODIER FABIEN; SALLÉ LAURENT; SODO ALFRED; VIGNE SYLVIE 权利人:PRINCIPIA BIOPHARMA INC 摘要:Disclosed herein are improved synthetic routes for making (R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1 H-imidazo[4,5-c]pyridin-2(3H)-one (tolebrutinbib). Also disclosed herein are novel compounds used in the synthesis of of (R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1 H-imidazo[4,5-c]pyridin-2(3H)-one.
专利号:US-6147159-A 优先权日:1998-09-30 标 题 :Compositions for organic synthesis on solid phase and methods of using the same 发明人:HU YONGHAN; LABADIE JEFFREY W; PORCO JR JOHN ANTHONY; TROST BARRY MARTIN 权利人:ARGONAUT TECHNOLOGIES 摘要:A modified solid support for use in solid phase synthesis which comprises: a solid support having a linker group extending therefrom having the general formula: wherein R1 and R2 are each independently selected from the group consisting of alkyl, cycloalkyl, aryl, alkoxy, aryloxy, fluorine, chlorine, iodine and bromine.
专利号:US-7973109-B2 优先权日:2007-03-29 标 题 :Crosslinked type layered metal phosphonate compound, production process therefor, non-crosslinked type layered metal phosphonate compound, production process therefor, as well as stock solution 发明人:OGATA SHIN-ICHI; FUKUSHIMA YOSHIAKI; KAWASUMI MASAYA 权利人:TOYOTA CHUO KENKYUSHO KK 摘要:A process for producing a crosslinked type or non-crosslinked type layered metal phosphonate compound including a reaction step of reacting two or more members selected from organic diphosphonic acids or monophosphonic acids, or derivatives thereof having predetermined conditions and a metal source capable of forming an ion of a hexacoordinate metal atom as a central atom (M) of a metal oxide octahedron upon reaction under the presence of a sulfuric acid catalyst, a crosslinked or non-crosslinked metal phosphonate compound obtained by the process, as well as a stock solution used for the synthesis of the crosslinked or non-crosslinked type layered metal phosphonate compound described above.
专利号:US-3651151-A 优先权日:1964-12-04 标 题 :Preparation of polyphenyl ether from dihydric phenols 发明人:BRIDGER ROBERT F; KINNEY ROBERT E; WILILAMS ALBERT L 权利人:MOBIL OIL CORP 摘要:DIHYDRIC PHENOIS CAN BE USED DIRECTLY IN THE ULLMANN ETHER SYNTHESIS BY USING A COPPER SALT CATALYST AND AN AMINE SOLVENT THAT DISSOLVES THE CATALYST BY FORMING COORDINATE COVALENT BONDS WITH COPPER IONS.
专利号:US-9700872-B1 优先权日:2016-07-01 标题:Superpolar chromatographic stationary phases and extraction sorbents and their methods of synthesis 发明人:KABIR ABUZAR; FURTON KENNETH G 权利人:KABIR ABUZAR; FURTON KENNETH G; UNIV FLORIDA INT 摘要:A superpolar sorbent network is a sol-gel network of at least one metal oxide precursor condensed and at least one polyhydroxy molecule. The metal oxide precursor is a silicate precursor, aluminate precursor, titanate precursor, zirconate precursor, germinate precursor, or any combinations thereof, and the polyhydroxy molecule has a multiplicity of hydroxyl groups. The polyhydroxy molecule can be an organic molecule derived from nature. The superpolar sorbent network can be used as a particulate or bulk sorbent for sampling or removal of analytes or contaminants from an environment or can be coated on a tube or particulate substrate for use as a chromatographic stationary phase.
[参考文献]: Sheng Wang, Et Al. Characterization Of The Molecular Degradation Mechanism Of Diphenyl Ethers By Cupriavidus Sp. Ws. Environ Sci Pollut Res Int. 2015 Nov;22(21):16914-26.
合成参考文献
摘要:Stanforth, S. P., Science of Synthesis Knowledge Updates, (2015) 1, 182. 摘要:Trejos, A.; Odell, L. R., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 3, 359. 摘要:Nakao, Y., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 1, 367. 摘要:USEPA/Office of Water; Federal-State Toxicology and Risk Analysis Committee (FSTRAC). Summary of State and Federal Drinking Water Standards and Guidelines (11/93) To Present 摘要:Patterson JW, Kodukala PS; Chem Eng Prog 77: 48-55 (1981)