CAS: 95-81-8; 2-Chloro-5-Methylaniline

• 英文名称2-Chloro-5-Methylaniline
• 中文名称2-氯-5-甲基苯胺
• IUPAC名称2-chloro-5-methylaniline
• 其它别名3-氨基-4-氯甲苯; 2氯5甲基苯胺; 6-Chloro-M-Toluidine; 2-Chloro-5-Methylaniline
• CAS编号95-81-8
• MFCD编号:MFCD00007674
• EINECS号:202-454-7
• FDA UNII编号:33NGJ21B5B
• 分子式:C7H8ClN
• 分子量:141.6
• 产品CID: 2012468
• 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

• 相似结构搜索
• 产品信息参考;
• InChIKey: HPSCXFOQUFPEPE-UHFFFAOYSA-N
• InChI=1S/C7H8ClN/c1-5-2-3-6(8)7(9)4-5/h2-4H,9H2,1H3…
• 计算化学: 氢键受体数1.0氢键供体数1可旋转键数0

物理性质

• 熔点29-30°C
• 沸点228-230°C at 760 mmHg
• 闪点107°C
• 密度1.2±0.1 g/cm3
• pKa:2.78±0.10(预测)
• PSA:26.02
• LogP:2.23062
• 折射率1.585
• 蒸汽压0.1±0.4 mmHg at 25°C
• 溶解性Chloroform (Sparingly), Methanol (Slightly)
• 敏感性避免与强氧化剂接触。
• 外观形态白色至几乎白色粉末至块状物
• 储存条件请置于阴暗处, 惰性气氛中,室温
• 产品应用该化合物用于抗病毒剂抗疫苗和LA CROSSE病毒的潜在用途的乙酰基尿衍生物.

MSDS等安全信息

• GHS象形图
• GHS符号GHS07;
  注释: Exclamation mark
• 危险类别急性毒性 类别4(吸入)
  急性毒性 类别4(经皮)
  急性毒性 类别4(经口)
  特定目标器官毒性 - 单次接触 类别3
  皮肤腐蚀/刺激 类别2
  严重眼刺激 类别2
  急性毒性 类别3(吸入)
  急性毒性 类别3(经皮)
  急性毒性 类别3(经口)
  特定目标器官毒性-单次接触 类别1
  特定目标器官毒性-重复接触 类别1
  特定目标器官毒性-重复接触 类别2
• 警示词Warning(警告)
• 危险描述H332 |吸入有害.
  H312 |皮肤接触有害.
  H302 |吞咽有害.
  H335 |可能引起呼吸道刺激.
  H315 |造成皮肤刺激.
  H319 |造成严重眼刺激.
  H331 |吸入会中毒.
  H311 |皮肤接触会中毒.
  H301 |吞咽会中毒.
  H370 |损害器官.
  H372 |长期或反复接触损害器官.
  H373 |长期或反复接触可能损害器官.
• 防范说明P264-P270-P330-P405-P501
• 危险等级6.1
• UN编号2239.0
• 危险品标志Xn
• 风险等级Harmful
• 包装等级Ⅲ
• 安全声明26-28-45-36/38-33-20/21/22
• 危险类别码20/21/22-36/37/38-36/37-28-26
• WGK Germany3

欧盟法规

上下游产品

合成工艺路线路线简述

• 89-60-1 = 95-81-8
  反应条件:1.1 Reagents: Hydrazine Hydrate (1:1) Catalysts: Iron Hydroxide Oxide Solvents: Ethanol,Water; 5 H,75 °C
  标题:Industrial Cunninghamia Lanceolata Carbon Supported Feo(Oh) Nanoparticles-Catalyzed Hydrogenation Of Nitroarenes
  作者:Li,Dingzhong; Lu,Hao; Yang,Tianbao; Xing,Chen; Sun,Tulai; Et Al
  参考文献:Catalysis Communications 日期:2022 卷标:162]
  
  2887929-43-1 = 95-81-8
  反应条件:1.1 Reagents: Potassium Carbonate Catalysts: Cupric Acetate Solvents: Ethanol; 8 - 12 H,100 °C
  标题:Exploration Of Copper(Ii) Acetate Catalyzed Regioselective Ethoxylation Of O-Haloanilides With Picolinamide As A Directing Group
  作者:Li,Xiaoyi; Qin,Dingmei; Li,Yanping; Mao,Zewei
  参考文献:Synlett 日期:2023 卷标:34(3) 页码:253-258]
  
  89-60-1 = 95-81-8
  反应条件:1.1 Reagents: Sodium Borohydride Catalysts: Platinum Solvents: Water; 2 - 3 H,25 °C
  标题:Immobilization Of Platinum Nanoparticles On The Functionalized Chitosan Particles: An Efficient Catalyst For Reduction Of Nitro Compounds And Tandem Reductive Ugi Reactions
  作者:Hamzavi,Seyedeh Fazileh; Jamili,Shahla; Yousefzadi,Morteza; Mashinchian Moradi,Ali; Amrollahi Biuki,Narges
  参考文献:Molecular Diversity 日期:2020 卷标:24(4) 页码:985-995]
  
  89-60-1 = 95-81-8
  反应条件:1.1 Reagents: Cobalt Sulfate (Coso4) Heptahydrate,Sodium Borohydride Solvents: Ethanol,Water; 0 °C; 10 Min,Rt1.2 Reagents: Water; Rt
  标题:A Co2B Mediated Nabh4 Reduction Protocol Applicable To A Selection Of Functional Groups In Organic Synthesis
  作者:Lundevall,Frida Johanne; Elumalai,Vijayaragavan; Drageset,Audun; Totland,Christian; Bjorsvik,Hans-Rene
  参考文献:European Journal Of Organic Chemistry 日期:2018 卷标:2018(26) 页码:3416-3425]
  
  89-60-1 = 95-81-8
  反应条件:1.1 Reagents: Hydrazine Hydrate (1:1) Catalysts: Carbon Solvents: Ethanol; 2 H,90 °C
  标题:N,S Co-Doped Hierarchically Porous Carbon Materials For Efficient Metal-Free Catalysis
  作者:Hu,Xiwei; Sun,Xun; Song,Qiang; Zhu,Yangyang; Long,Yu; Et Al
  参考文献:Green Chemistry 日期:2020 卷标:22(3) 页码:742-752]
  
  89-60-1 = 95-81-8
  反应条件:1.1 Reagents: Iron Solvents: Acetic Acid; 30 Min,Rt -> 90 °C
  标题:Synthesis And Antileishmanial Evaluation Of Thiazole Orange Analogs
  作者:Abdelhameed,Ahmed; Liao,Xiaoping; Mcelroy,Craig A.; Joice,April C.; Rakotondraibe,Liva; Et Al
  参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2020 卷标:30(1)]
  
  89-60-1 = 95-81-8
  反应条件:1.1 Reagents: Hydrochloric Acid
  标题:Synthesis Of 4-Halotoluene-2- And 3-Sulfonic Acids,And Sulfonation Mixtures Of 4-Halotoluenes By The Hplc (High Performance Liquid Chromatography) Analysis
  作者:Muramoto,Yoshirio; Asakura,Hideyuki; Suzuki,Hitomi
  参考文献:Kinki Daigaku Kogakubu Kenkyu Hokoku 日期:1991 卷标:25 页码:73-9]
  
  = 95-81-8 [标题:Reaction Conditions
  标题:Process For Preparing 4,5-Difluorobenzaldehydes From Chlorofluorobenzaldehydes
  参考文献:European Patent Organization]
  
  89-60-1 = 95-81-8
  反应条件:1.1 Reagents: Hydrogen Catalysts: Nickel,Carbon Solvents: Methanol,Water; 4 H,2 Mpa,100 °C
  标题:Nickel Nanoparticles Encapsulated In Carbon Nanotubes As An Efficient And Robust Catalyst For Hydrogenation Of Nitroarenes
  作者:Ding,Shunmin; Cheng,Dan; Xiao,Weiming; Ma,Xiaohua; Zeng,Rong; Et Al
  参考文献:Catalysis Letters 日期:2023 卷标:153(2) 页码:595-604]
  
  89-60-1 = 95-81-8
  反应条件:1.1 Reagents: Hydrazine Hydrate (1:1) Catalysts: Iron Hydroxide Oxide Solvents: Ethanol; 60 - 70 °C
  标题:Green Preparation Of Carbon-Supported Iron-Based Catalyst And Its Application In Synthesis Of Anticancer Inhibitor Intermediates
  参考文献:World Intellectual Property Organization]
  
  89-60-1 = 95-81-8
  反应条件:1.1 Reagents: Iron,Hydrochloric Acid,Ammonium Chloride Solvents: Water; 1.5 H,Rt -> Reflux1.2 Reflux; 3 H,Reflux1.3 Reagents: Sodium Carbonate Solvents: Water; Ph 9 - 10
  标题:Synthesis Of 4-Chloro-3-Fluorotoluene And 4-Bromo-3-Fluorotoluene
  作者:Zhao,Haoyu; Xue,Xuming; Jiang,Tao
  参考文献:Jingxi Shiyou Huagong 日期:2007 卷标:24(1) 页码:39-43]
  
  89-60-1 = 95-81-8
  反应条件:1.1 Reagents: Sodium Dithionite
  标题:Alkaline Soil Degradation And Crop Safety Of 5-Substituted Chlorsulfuron Derivatives
  作者:Wu,Lei; Hua,Xue-Wen; Li,Yong-Hong; Wang,Zhong-Wen; Zhou,Sha; Et Al
  参考文献:Molecules 日期:2022 卷标:27(10)]
  
  89-60-1 = 95-81-8
  反应条件:1.1 Reagents: Hydrogen Catalysts: Carbon Solvents: Methanol,Water; 3 H,5 Bar,90 °C
  标题:Co,N-Codoped Porous Carbon-Supported Coyzns With Superior Activity For Nitroarene Hydrogenation
  作者:Zhang,Guangji; Tang,Feiying; Wang,Xiaoying; An,Ping; Wang,Liqiang; Et Al
  参考文献:Acs Sustainable Chemistry & Engineering 日期:2020 卷标:8(15) 页码:6118-6126]
  
  89-60-1 = 95-81-8
  反应条件:1.1 Catalysts: Cobalt (Reaction Products With 2-Methylimidazole,M-Aminophenol,Formaldehyde Mesoporous Yolk-Shell Supported) Solvents: Ethanol; 5 Min,80 °C1.2 Reagents: Hydrazine Hydrate (1:1); 10 Min,80 °C
  标题:Co-Mof-Derived Hierarchical Mesoporous Yolk-Shell-Structured Nanoreactor For The Catalytic Reduction Of Nitroarenes With Hydrazine Hydrate
  作者:Yuan,Man; Zhang,Hongbo; Yang,Chen; Wang,Fanhao; Dong,Zhengping
  参考文献:Chemcatchem 日期:2019 卷标:11(14) 页码:3327-3338]
  
  89-60-1 = 95-81-8
  反应条件:1.1 Reagents: Hydrazine Hydrate (1:1) Catalysts: Cyanuric Chloride-Piperazine Copolymer Solvents: Ethanol,Water; 3.5 H,100 °C
  标题:Two-Dimensional Covalent Organic Frameworks As Self-Template Derived Nitrogen-Doped Carbon Nanosheets For Eco-Friendly Metal-Free Catalysis
  作者:Hu,Xiwei; Long,Yu; Fan,Mengying; Yuan,Man; Zhao,Hong; Et Al
  参考文献:Applied Catalysis 日期:2019 卷标:244 页码:25-35]
  
  89-60-1 = 95-81-8
  反应条件:1.1 Reagents: Sodium Borohydride Catalysts: Palladium (Reaction Product With Porous Organic Polymer),Cyanuric Chloride-Piperazine Copolymer Solvents: Ethanol,Water; 15 Min,25 °C
  标题:Ultra-Fine Pd Nanoparticles Confined In A Porous Organic Polymer: A Leaching-And-Aggregation-Resistant Catalyst For The Efficient Reduction Of Nitroarenes By Nabh4
  作者:Yuan,Man; Yang,Renzi; Wei,Shuoyun; Hu,Xiwei; Xu,Dan; Et Al
  参考文献:Journal Of Colloid And Interface Science 日期:2019 卷标:538 页码:720-730]
  
  89-60-1 = 95-81-8
  反应条件:1.1 Reagents: Sodium Borohydride Catalysts: Palladium (Aminal-Based Hypercrosslinked Polymer Supported),Ferrocene,Formyl-,Polymer With 1,3,5-Triazine-2,4,6-Triamine Solvents: Ethanol,Water; 15 Min,Rt
  标题:Aminal-Based Hypercrosslinked Polymer Modified With Small Palladium Nanoparticles For Efficiently Catalytic Reduction Of Nitroarenes
  作者:Xu,Dan; Wang,Fushan; Yu,Guiqin; Zhao,Hong; Yang,Jing; Et Al
  参考文献:Chemcatchem 日期:2018 卷标:10(20) 页码:4569-4577]
  
  89-60-1 = 95-81-8
  反应条件:1.1 Reagents: Iron,Hydrochloric Acid Solvents: Methanol,Water; 2 H,Rt1.2 Reagents: Sodium Bicarbonate Solvents: Water; Basified
  标题:Preparation Of Tricyclic Compounds As Mpges-1 Inhibitors
  参考文献:World Intellectual Property Organization]
  
  89-60-1 = 95-81-8
  反应条件:1.1 Reagents: Hydrochloric Acid,Stannous Chloride Solvents: Ethanol,Water; 70 Min,60 °C1.2 Reagents: Sodium Hydroxide Solvents: Water; Ph 12
  标题:Substituted Tetrahydro-1H-Pyrido[4,3-B]Indoles As Serotonin Receptors Agonists And Antagonists For Treating Metabolic,Cns,And Gastrointestinal Disorders
  参考文献:United States

海关参考信息

• 2902300000-甲苯
  2903919090-氯苯
  2903991000-对氯甲苯
• 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
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