CAS: 77-03-2; 3,3-Diethylpiperidine-2,4-Dione

相似化合物

1824126-03-5 73290-32-1 1547067-72-0

📜2,2-二乙基乙酰乙酸乙酯置于甲醇,Palladium On Activated Charcoal,乙醇,Sodium Ethanolate体系中,化学反应生成 3,3-二乙基哌啶-2,4-二酮
参考文献:Tsukita,Yakugaku Zasshi/journal Of The Pharmaceutical Society Of Japan,1949,Vol. 69,P. 194
标题:Tsukita,Yakugaku Zasshi/journal Of The Pharmaceutical Society Of Japan,1949,Vol. 69,P. 194

专利信息

专利号:WO-9729091-A1
优先权日:1996-02-09
标题:Balanol analogues
发明人：NIELSEN JOHN; LYNGSOE LARS OLE
权利人:AUDA PHARMACEUTICALS APS; NIELSEN JOHN; LYNGSOE LARS OLE
摘要:The present invention relates to a solid phase methodology for the preparation of a combinatorial library of structural analogues of the natural product balanol (ophiocordin, azepinostatin), which is a protein kinase C (PKC) and protein kinase A (PKA) inhibitor. The method comprises solid-phase synthesis of the analog variants of balanol whereby a high molecular diversity is introduced. The synthetic scheme is based on a retrosynthetic analysis of the native structure which revealed three main building blocks suitable as templates for modification. The dicarboxy-functional moiety can be immobilised to the polymer support either as the monoallyl ester or as the internal anhydride. The libraries produced by the method are especially suited for high throughput screening of potential drug candidates for the treatment of mammals, especially humans.

专利号:WO-9710263-A1
优先权日:1995-09-12
标 题 :Actinomycin d analogues
发明人：TONG GLENN; NIELSEN JOHN
权利人:AUDA PHARMACEUTICALS APS; TONG GLENN; NIELSEN JOHN
摘要:The present invention relates to new compounds being structurally and functionally similar to Actinomycin D and to combinatorial libraries of such compounds. The Actinomycin D analogues according to the present invention comprise two linear or cyclic peptide moieties constituted by α-amino acids, β-amino acids and/or longer chain φ-amino acids, and a difunctional group which preferably is a cyclic entity, in particular, an aromatic or heteroaromatic entity acting as an intercalator group. Specific compounds and a library of such compounds may be prepared using conventional solid phase peptide synthesis (SPPS) methodologies. The novel compounds are expected to have affinity for DNA and RNA, and libraries thereof may therefore advantageously be used for screening purposes. Furthermore, a novel double-combinatorial technique that may be used in the preparation of librairies of broader classes of compounds has been developed.

专利号:RU-2166503-C2
优先权日:1998-01-02
标题:Derivatives of thiazole, method of their synthesis, composition based on thereof and intermediate compound