CAS: 766-49-4; 1-Ethynyl-2-Fluorobenzene

上下游产品

CAS号178173-84-7 4-(2-fluoro-phe... | CAS号394-46-7 2-氟苯乙烯 | CAS号445-26-1 1-(2-氟苯基)-1-乙醇 | CAS号446-52-6 邻氟苯甲醛 | CAS号1072-85-1 1-溴-2-氟苯 | CAS号18944-77-9 (E)-3-(2-氟苯基)丙烯酸 | CAS号342-19-8 (2RS:3SR)-2,3-d... | CAS号50919-06-7 2-(2-氟苯基)乙醇 | CAS号75321-85-6 2-氟苯乙醛 | CAS号445-26-1 1-(2-氟苯基)-1-乙醇 | CAS号445-28-3 2-氟苯甲酰胺 | CAS号29778-27-6 1-fluoro-2-(2-p... | CAS号1645-20-1 4H-1-Benzopyran... | CAS号704-97-2 3-(2-氟苯基)丙炔酸 | CAS号52765-22-7 2-(2-氟苯基)-1H-吲哚

2-氟碘苯置于甲醇,Bis-Triphenylphosphine-Palladium(II) Chloride,Copper(L) Iodide,Potassium Hydrogen Difluoride,三乙胺体系中,化学反应生成 1-乙炔基-2-氟苯
参考文献:高性能不对称二苯并[d,D']噻吩并[2,3-B;4,5-B']二噻吩半导体的多米诺协议
标题:高性能不对称二苯并[d,D']噻吩并[2,3-B;4,5-B']二噻吩半导体的多米诺协议
摘要:开发了一种三硫自由基阴离子(s 3 .−)触发的多米诺噻吩环化策略,用于合成二苯并[D,D']噻吩并[2,3-B ;4,5-B ']二噻吩(dbtdt).该多米诺骨牌协议的特点是无需金属催化剂,在一锅反应中形成六个 C−s 和一个 C−c 键.通过控制实验,中间捕获实验等提出了一种合理的机制.dbtdt独特的不对称结构赋予其人字形堆积结构和分子间弱的s⋅⋅⋅s相互作用以及高转移积分,从而实现高载流子有机场效应晶体管的迁移率为1.52 Cm 2 V-1 S-1 .
DOI:10.1002/anie.202400803

专利信息

专利号:US-8697862-B2
优先权日:2008-05-16
标题 :Synthesis of galactoside inhibitors
发明人：NILSSON ULF
权利人:NILSSON ULF; GALECTO BIOTECH AB
摘要:Novel synthesis routes for preparation of thiodigalactosides and intermediates are presented. The method includes the use of a 3-azido-galactosyl thiouronium salt derivative, which is activated to the corresponding thiol in situ, which in turn is directly reacted with a 3-azido-galactosyl bromide resulting in the 3,3′-di-azido-thio-di-galactoside before the thiol has a chance to reduce the azido 10 group. Hence, in situ formation of the 3-azido-galactosyl thiol from the thiouronium salt is essential in the synthesis procedure, because any other method that generate the thiol separately results in extensive unwanted azide reduction.

专利号:US-2022265691-A1
优先权日:2019-07-12
标 题 :Methods for use of gene expression as an indicator of e-selectin inhibitor efficacy and clinical outcome for multiple tumor types
发明人：MAGNANI JOHN L; FOGLER WILLIAM E; THACKRAY HELEN M; FELDMAN ERIC J; STEWART DAVID
权利人:GLYCOMIMETICS INC
摘要:Cancer patients that express high levels of the E-selectin ligand (sialyl Lea/x) on their tumors have a poorer outcome. Interestingly, relapsed/refractory acute myeloid leukemia (AML) patients expressing high levels of sialyl Lex on their blasts show the greatest therapeutic response when treated with the E-selection inhibitor compound of Formula I. Transcriptome profiling of E-selectin ligand-forming glycosylation genes showed that ST3GAL4 and FUT7 were consistently expressed in the majority of cancers evaluated. Poor survival outcomes of FLT3-mutated AML patients that express high levels of ST3GAL4 and FUT7 implicated E-selectin in this disease state. These genes may be predictive biomarkers in AML patients. Methods of treatment of cancer comprising screening AML patients for expression of genes that contribute to the synthesis of the E-selectin ligand sialyl Lex, then treating those patients with an E-selection inhibitor, are disclosed.

专利号:WO-2013131872-A1
优先权日:2012-03-05
标 题 :Imaging neural activity
发明人：BETTS HELEN MAY; DESMOND ANTONIA; ROBINS EDWARD GEORGE
权利人:GE HEALTHCARE LTD; UCL SCHOOL OF PHARMACY
摘要:The present invention provides a novel radiofluorinated compound for imaging voltage-gated sodium channels (VGSCs) that is more straightforward to synthesise than the known radiofluorinated phenoxyphenyl pyrazole carboxylic acid compounds. The compound of the present invention demonstrates specific uptake and retention in key tissues as well as good in vivo stability. Also provided by the present invention is a radiopharmaceutical composition comprising the radiofluorinated compound of the invention, precursor compounds and methods for the synthesis of said radiofluorinated compound, and methods for using said radiofluorinated compound.

专利号:US-10799522-B2
优先权日:2015-07-27
标 题 :Compositions and methods relating to galectin detection
发明人：GELOVANI JURI G; TURKMAN NASHAAT; POPOV VADIM; BONOMI ROBIN; SHAVRIN ALEKSANDR; ALTHER PHILIP; BORISOV ANDREI
权利人:UNIV WAYNE STATE
摘要:Compositions and methods for detection and assessment of galectins are provided by the present invention, including labeled compositions, pharmaceutical composition including a labeled composition for galectin detection and a pharmaceutically acceptable carrier, method of aiding in diagnosis and/or treatment of a condition characterized by upregulation of one or more galectins in a subject in need thereof and precursor compositions for synthesis of chemical compositions, including but not limited to labeled compositions for detection and assessment of galectins.

专利号:WO-2009139719-A9
优先权日:2008-05-16
标 题 :Novel synthesis of galactoside inhibitors

专利号:CN-104860864-A
优先权日:2015-06-04
标 题 :A new method for the synthesis of 2-carbonyl-5-alkynylpyrrole compounds