2-氯金刚烷置于甲醇体系中,化学反应生成 2-金刚烷醇 参考文献:Neighboring Group Effects In The .Beta.-Halo Amines. Synthesis And Solvolytic Reactivity Of The Anti-4-Substituted 2-Azaadamantyl System 标题:Neighboring Group Effects In The .Beta.-Halo Amines. Synthesis And Solvolytic Reactivity Of The Anti-4-Substituted 2-Azaadamantyl System 摘要: DOI:10.1021/jo00337A026
专利号:US-8119835-B2 优先权日:2006-12-28 标 题:Method for preparation of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphtoic acid 发明人:KALVINSH IVARS; CHERNOBROVIJS ALEKSANDRS; TRIBULOVICH VYACHESLAV; LABEISH VLADIMIR 权利人:KALVINSH IVARS; CHERNOBROVIJS ALEKSANDRS; TRIBULOVICH VYACHESLAV; LABEISH VLADIMIR; JSC GRINDEKS 摘要:A method for preparation of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid is disclosed based on “one potâ€? synthesis approach including a direct synthesis of boronic acid derivative from 2-(1-adamantyl)-4-bromoanisole and cycloboranes with a subsequent Suzuki-Miyaura coupling with 6-halonaphtenoates and basic hydrolysis of the reaction product in ethylene glycol or 1,2-propanediol.
专利号:US-2008125354-A1 优先权日:2005-11-21 标题 :Selective inhibition of matrix metalloproteinases 发明人:FIELDS GREGG B; HAMMER ROBERT 权利人:UNIV FLORIDA ATLANTIC; UNIV LOUISIANA STATE 摘要:Synthetic triple-helical peptides (THPs) are used for the design and synthesis of triple-helical transition state analog inhibitors. These inhibitors feature a phosphonate ester or phosphinic moiety in place of the scissle bond. These groups inhibit MMPs, and methods been developed for their convenient incorporation within a peptide sequence by solid-phase methods.
专利号:WO-9526975-A1 优先权日:1994-03-30 标题 :Acyclic aliphatic branched alkyl groups as constituents of protective groups bound to side chains of amino-acid moieties, and their use in the preparation of peptide, polypeptide or protein structures 发明人:UNDEN ANDERS 权利人:UNDEN ANDERS 摘要:A protective group bound to a side chain of an amino-acid moiety, which group is an aliphatic acyclic branched alkyl group protecting a thiol, hydroxyl, or carboxyl group or an aliphatic acyclic branched alkoxycarbonyl group protecting an amino group or heterocyclic nitrogen, wherein the alkyl and alkoxy entities have from 6 to 18 carbon atoms and have at least two identical alkyl chains, is described. Further, the use of such a protective group bound to a side chain of an amino-acid moiety in the synthesis of peptides, polypeptides and proteins is disclosed.
专利号:US-5124498-A 优先权日:1990-10-16 标 题:Synthesis of olefins from carbonyls 发明人:SHEN DONG M 权利人:MOBIL OIL CORP 摘要:The invention provides, in a first aspect, a method for preparing a reduced metal reagent comprising the steps of providing a halide salt of a metal having a more positive reduction potential than Na in admixture with liquid Na in substantially stoichiometric quantities in the presence of an ogranic solvent characterized by boiling point, measured at atmospheric conditions, at least equal to the melting point of Na, to reduce substantially all of the halide salt to reactive metal reagent and to convert substantially all of said Na to a Na halide salt. n The invention further provides, in a second aspect, a method for converting carbonylsin the presnece of the reduced metal reagent prepared in accordance with the invention.
专利号:US-5430193-A 优先权日:1994-04-22 标 题:Synthesis of 4-hydroxy-2-adamantanes and related compounds 发明人:SHEN DONG-MING 权利人:MOBIL OIL CORP 摘要:The invention provides a method for converting a lactone of a diamondoid compound to the hydroxyketone of the diamondoid compound wherein the hydroxyl group and the carbonyl group are separated by at least one bridgehead carbon comprising reacting an anhydride containing from about 2 to about 20 carbon atoms with the lactone of the diamondoid compound in the presence of acid.
专利号:WO-2012163936-A1 优先权日:2011-05-31 标 题 :Process for the synthesis of benzotriazoles useful as uv-filters 发明人:PRESCHEL MICHAEL; ROEDER MICHAEL; SCHLIFKE-POSCHALKO ALEXANDER; ZHANG KESHENG 权利人:DSM IP ASSETS BV; PRESCHEL MICHAEL; ROEDER MICHAEL; SCHLIFKE-POSCHALKO ALEXANDER; ZHANG KESHENG 摘要:The invention relates to an improved process for the manufacture of novel benzotriazoles as well to novel benzotriazoles obtained by the novel process. This novel economical process provides products in high purity and yields.
[参考文献]: Andrzej Orzeszko, Et Al. Synthesis And Antimicrobial Activity Of New Adamantane Derivatives Iii. Farmaco. 2002 Aug;57(8):619-24. [参考文献]: J P Miller, Et Al. Photoaffinity Labeling Of Cytochrome P450 2B4: Capture Of Active Site Heme Ligands By A Photocarbene. Biochemistry. 1994 Jan 25;33(3):807-17. [参考文献]: Koichi Mitsukura, Et Al. Regioselective Hydroxylation Of Adamantane By Streptomyces Griseoplanus Cells. Appl Microbiol Biotechnol. 2006 Jul;71(4):502-4. [参考文献]: Marisa Spiniello, Et Al. Low-Temperature X-Ray Structural Studies Of The Ester And Ether Derivatives Of Cis- And Trans-4-Tert-Butyl Cyclohexanol And 2-Adamantanol: Application Of The Variable Oxygen Probe To Determine The Relative Sigma-Donor Ability Of C-H And C-C Bonds. Org Biomol Chem. 2003 Sep 7;1(17):3094-101.
合成参考文献
摘要:Castle, S. L., Science of Synthesis Knowledge Updates, (2011) 4, 355. 摘要:Podlech, J., Science of Synthesis Knowledge Updates, (2018) 4, 141. 摘要:Margaretha, P., Science of Synthesis Knowledge Updates, (2014) 2, 439. 摘要:Scammells, P. J., Science of Synthesis Knowledge Updates, (2013) 2, 445. 摘要:Herter, S.; Turner, N. J., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 3, 150.