CAS: 69395-13-7; 4-(2-Hydroxyethyl)Benzonitrile

该化合物是一种多用途有机化合物,其成分为硝酸(-CN)和氢氧乙基(-CH2CH2OH)的功能组,附于苯环. 这种双功能结构使它成为有机合成中有价值的中间体,特别是制药,农用化学品和特殊材料. 硝酸组可以进行水解等进一步转化,变成碳酸或减少氨,而氢氧乙基水体允许其产生发酵或酯化反应. 其高纯度和稳定性确保多步合成的可靠性能. 由于它具有平衡的再反应性和与各种反应条件的兼容性,该复合体在生产活性制药成分(APIs)和液晶材料方面特别有用.

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上下游产品

CAS号76113-58-1 4-(2-氧代乙基)苯甲腈 | CAS号873-74-5 对氨基苯腈 | CAS号100-27-6 对硝基苯乙醇 | CAS号103-45-7 乙酸苯乙酯 | CAS号544-92-3 氰化亚铜 | CAS号104-10-9 2-(4-氨基苯基)乙醇 | CAS号143-33-9 氰化钠 | CAS号5462-71-5 4-氰基-苯乙酸 | CAS号72054-56-9 4-(2-溴乙基)苯甲腈 | CAS号132224-93-2 对氰基苯乙胺 | CAS号619-65-8 对氰基苯甲酸 | CAS号136081-18-0 2-(4-(氨基甲基)苯基)乙烷-1-醇 | CAS号134403-90-0 4-(2-hydroxyeth... | CAS号714568-34-0 2-[4-(4,5-二氢-1H... | CAS号76113-58-1 4-(2-氧代乙基)苯甲腈

合成工艺路线路线简述

  • 合成目标产物 4-(2-Hydroxyethyl)Benzonitrile 主要起始原料 Methyl 4-Bromophenylacetate
  • (文献来源)合成步骤主要原料 Methyl 4-Bromophenylacetate
📜4-溴苯乙酸甲酯置于三乙基硼氢化钠体系中,用 四氢呋喃,N-甲基吡咯烷酮 作为反应溶剂,化学反应 24.0H,反应生成 4-(2-羟基乙基)苯甲腈
参考文献:选择性a2A受体拮抗剂
标题:选择性a2A受体拮抗剂
摘要:本发明提供一种选择性a 2A 受体拮抗剂,具体地,本发明提供了通式(I)所示的选择性a 2A 受体拮抗剂,包含其的药物组合物,其制药用途和治疗用途: 通式(I)中各基团的定义如说明书中所述.

海关参考信息

专利信息


专利号:US-9550000-B2
优先权日:2011-09-09
标题 :Compositions, methods, and systems for the synthesis and use of imaging agents
发明人:ROBINSON SIMON P; YU MING
权利人:ROBINSON SIMON P; YU MING; LANTHEUS MEDICAL IMAGING INC
摘要:The present invention relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, the imaging agent is enriched in 18 F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs. In some embodiments, methods and compositions for assessing perfusion and innervation mismatch in a portion of a subject are provided.

专利号:US-2022339303-A1
优先权日:2011-09-09
标题 :Compositions, methods, and systems for the synthesis and use of imaging agents

专利号:US-2008176865-A1
优先权日:2005-06-15
标 题:Substituted arylpyrazoles
发明人:BILLEN DENIS; BOYLE JESSICA; CRITCHER DOUGLAS JAMES; GETHIN DAVID MORRIS; HALL KIM THOMAS; KYNE GRAHAM MICHAEL
权利人:PFIZER LTD
摘要:This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides.

专利号:EP-3567029-A1
优先权日:2011-09-09
标 题:Compositions, methods, and systems for the synthesis and use of imaging agents

专利号:CN-104159890-A
优先权日:2011-09-09
标 题 :Compositions, methods, and systems for synthesis and use of imaging agents

专利号:CA-2848147-A1
优先权日:2011-09-09
标 题 :Compositions, methods, and systems for the synthesis and use of imaging agents

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品牌试剂参考报价(招募中)

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

合成参考文献


参考文献:10.1007/978-94-011-3034-9_55
摘要:Albericio F, Robles J, Fernandez-Forner D, Palom Y, Celma C, Pedroso E, Giralt E, Eritja R. NPE-resin, a new approach to the solid-phase synthesis of protected peptides and oligonucleotides. 1991. In: Peptides 1990. : Springer Netherlands; 1991.
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