专利号:WO-2004076425-A1 优先权日:2003-02-21 标题:Improved synthesis of macrocyclic tetraamido compounds and new metal insertion process
专利号:US-7256177-B2 优先权日:2003-06-17 标题 :Lincomycin derivatives possessing antibacterial activity 发明人:LEWIS JASON G; ANANDAN SAMPATH K; O'DOWD HARDWIN; GORDEEV MIKHAIL F 权利人:VICURON PHARM INC 摘要:Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. The compounds of the subject invention may exhibit potent activities against bacteria, including Gram positive organisms, and may be useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.
专利号:US-7361743-B2 优先权日:2004-02-11 标 题 :Lincomycin derivatives possessing antibacterial activity 发明人:LEWIS JASON G; ANANDAN SAMPATH K; O'DOWD HARDWIN; GORDEEV MIKHAIL F; LI LIANSHENG 权利人:PFIZER 摘要:Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. The compounds of the subject invention may exhibit potent activities against bacteria, including Gram positive organisms, and may be useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.
专利号:US-7199106-B2 优先权日:2003-06-17 标题 :Lincomycin derivatives possessing antimicrobial activity 发明人:LEWIS JASON G; ANANDAN SAMPATH-KUMAR; O'DOWD HARDWIN; GORDEEV MIKHAIL F 权利人:VICURON PHARM INC 摘要:Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. The compounds of the subject invention may exhibit potent activities against bacteria, including gram positive organisms, and may be useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.
参考文献:10.1074/jbc.ra119.010201 摘要:Clausse V, Tao D, Debnath S, Fang Y, Tagad HD, Wang Y, Sun H, LeClair CA, Mazur SJ, Lane K, Shi Z, Vasalatiy O, Eells R, Baker LK, Henderson MJ, Webb MR, Shen M, Hall MD, Appella E, Appella DH, Coussens NP. Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens. Journal of Biological Chemistry. 2019 Nov;294(46):17654–68. doi: 10.1074/jbc.ra119.010201. 参考文献:10.1177/2472555219873068 摘要:Lee OW, Austin S, Gamma M, Cheff DM, Lee TD, Wilson KM, Johnson J, Travers J, Braisted JC, Guha R, Klumpp-Thomas C, Shen M, Hall MD. Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. SLAS Discov. 2020 Jan;25(1):9–20.