CAS: 59017-64-0; Ioxaglic Acid

该化合物是一种化学化合物,主要用作医疗成像中的对比剂,特别是用于计算断层扫描;它属于碘化对比介质类别,其特点是能够提高放射成像中内部结构的可见度;恶氧乙酸是一种水溶性化合物,便于在各种诊断程序中使用;其结构包括碘原子,该原子负责其放射性,可以对血管和器官进行更清晰的成像;该化合物一般是静脉注射,以其相对较老的反光剂而言,其表面阳性相对较低而闻名,这可以减少不良反应的风险;此外,恶氧酸还被设计成通过肾脏排出,使其适合正常肾功能的病人;

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    专利号:US-12006540-B2
    优先权日:2015-09-28
    标题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis
    发明人：JU JINGYUE; LI XIAOXU; CHEN XIN; LI ZENGMIN; KUMAR SHIV; SHI SHUNDI; GUO CHENG; REN JIANYI; HSIEH MIN-KANG; CHIEN MINCHEN; TAO CHUANJUAN; ERTURK ECE; KALACHIKOV SERGEY; RUSSO JAMES J
    权利人:UNIV COLUMBIA
    摘要:Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.

    专利号:US-2022233673-A1
    优先权日:2019-06-04
    标 题:METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STxB) MONOMERS AND OLIGOMERS, AND USES THEREOF
    发明人：BILLET ANNE; SCHMIDT FRÉDÉRIC; JOHANNES LUDGER; SERVENT DENIS; MOURIER GILLES; TARTOUR ÉRIC; KAY MICHAEL; FULCHER JAMES M
    权利人:INST CURIE; CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED; COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES CEA; APHP ASSIST PUBLIQUE HOPITAUX DE PARIS; UNIV PARIS; UNIV OF UTAH RESEARCH FOUDATION; UNIV UTAH RES FOUND
    摘要:A method of producing a monomer of a Shiga toxin B-subunit (STxB) protein or of a variant thereof by peptide chemical synthesis, as well as to a method of producing a pentamer of the STxB protein or of the variant thereof. The methods are particularly advantageous as they overcome major issues typically observed in peptide chemical synthesis, including solubility and purity issues.

    专利号:US-12269790-B1
    优先权日:2022-04-29
    标题:Process for the preparation of 2,4,6-triiodophenol derivatives
    发明人：BARANYAI ZSOLT; GUIDOLIN NICOL; LAZZARI FEDERICA; UGGERI FULVIO
    权利人:BRACCO IMAGING SPA
    摘要:The invention relates to a process for the preparation of a 2,4,6-triiodo-phenol derivative of formula (II), which is useful as an intermediate for the synthesis of conventional X-ray contrast agents, said process comprising the tri-iodination of the correspondent phenol derivative of said 2,4,6-triiodo-phenol derivative by means of an iodinating system comprising I 2 and an oxide or a salt of an element of group 11 of the periodic table.

    专利号:US-11959137-B2
    优先权日:2015-09-28
    标题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis

    专利号:US-2024376536-A1
    优先权日:2015-09-28
    标题 :Design and synthesis of novel disulfide linker based nucleotides as reversible terminators for dna sequencing by synthesis

    专利号:US-2022411860-A1
    优先权日:2015-09-28
    标题:Design and synthesis of novel disulfide linker based nucleotides as reversible terminators for dna sequencing by synthesis

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    合成参考文献


    摘要:Kiso to Rinsho. Clinical Report., 19(2411), 1985
    摘要:Iyakuhin Kenkyu. Study of Medical Supplies., 18(474), 1987
    摘要:US Natl Inst Health; DailyMed. Current Medication Information for HEXABRIX (ioxaglate meglumin and ioxaglate sodium) injection (December 2010). Available from, as of June 25, 2012:
    摘要:Lyman WJ et al; Handbook of Chemical Property Estimation Methods. Washington, DC: Amer Chem Soc pp. 7-4, 7-5, 8-12 (1990)
    摘要:Lee HC et al; J Nephrol 24 (3): 376-80 (2011)
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