CAS: 54907-61-8; 2-Iodoacetic Anhydride

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CAS号64-69-7 碘乙酸 | CAS号38020-81-4 氯化碘乙酸 | CAS号7719-09-7 氧氯化硫 | CAS号144-48-9 碘代乙酰胺 | CAS号5434-66-2 4-[(2-iodoacety...

📜碘乙酸置于n,N'-二环己基碳二亚胺体系中,用 乙腈 作为反应溶剂,化学反应生成 碘代乙酸酐
参考文献:Synthesis And Characterisation Of A New Dna-Binding Bifunctional Ruthenium(II) Complex
标题:Synthesis And Characterisation Of A New Dna-Binding Bifunctional Ruthenium(II) Complex
摘要:一种新的dna结合分子ru(Tap)2Poq2+已经被合成并表征,其中多吡啶金属钌(II)复合物通过一个灵活的链连接到氨基氯喹.这一复合物被视为双功能,因为它包含两种不同结合模式和光反应性的部分.该化合物的1H NMR数据表明两种分子物种之间存在平衡.ru(Tap)2Poq2+的光谱特性在吸收和荧光方面进行了检查,并与不包含氨基氯喹部分的相应钌(II)复合物ru(Tap)2Phen2+进行了比较.相对量子产率和寿命显示,Mlct激发态行为受到连结喹啉的影响.平衡中两种物种之一的分子内光诱导电子转移被认为是导致钌(II)复合物荧光猝灭的原因.基于荧光和热变性研究,报告了ru(Tap)2Poq2+与dna及[poly(D[a-T])]2的结合特性初步结果.当ru(Tap)2Poq2+与核酸相互作用时,其分子内荧光猝灭受到抑制.因此,在存在多核苷酸时所产生的发射相比于参考复合物ru(Tap)2Phen2+观测到的荧光增强更加显著.
DOI:10.1039/ft9938903261

专利信息

专利号:US-6262251-B1
优先权日:1995-10-19
标题 :Method for solution phase synthesis of oligonucleotides
发明人：PIEKEN WOLFGANG; MCGEE DANNY; SETTLE ALECIA; ZHAI YANSHENG; HUANG JIANPING
权利人:PROLIGO LLC
摘要:This invention discloses an improved method for the sequential solution phase synthesis of oligonucleotides. The method lends itself to automation and is ideally suited for large scale manufacture of oligonucleotides with high efficiency.

专利号:WO-9847910-A1
优先权日:1997-04-21
标题:Method for solution phase synthesis of oligonucleotides
发明人：PIEKEN WOLFGANG; MCGEE DANNY; SETTLE ALECIA; ZHAI YANSHENG; HUANG JIANPING; HILL KEN; SMITH RANDALL S
权利人:NEXSTAR PHARMACEUTICALS INC; PIEKEN WOLFGANG; MCGEE DANNY; SETTLE ALECIA; ZHAI YANSHENG; HUANG JIANPING; HILL KEN; SMITH RANDALL S
摘要:This invention discloses an improved method for the sequential solution phase synthesis of oligonucleotides. The method lends itself to automation and is ideally suited for large scale manufacture oligonucleotides with high efficiency.

专利号:US-5874532-A
优先权日:1997-01-08
标 题 :Method for solution phase synthesis of oligonucleotides and peptides
发明人：PIEKEN WOLFGANG; GOLD LARRY
权利人:NEXSTAR PHARMACEUTICALS INC
摘要:This invention discloses an improved method for the sequential solution phase synthesis of oligonucleotides and peptides. The method lends itself to automation and is ideally suited for large scale manufacture oligonucleotides with high efficiency.

专利号:US-6001966-A
优先权日:1995-10-19
标题 :Method for solution phase synthesis of oligonucleotides and peptides
发明人：PIEKEN WOLFGANG; GOLD LARRY
权利人:PROLIGO LLC
摘要:This invention discloses an improved method for the sequential solution phase synthesis of oligonucleotides and peptides. The method lends itself to automation and is ideally suited for large scale manufacture oligonucleotides with high efficiency.

专利号:US-6229055-B1
优先权日:1996-04-12
标题 :Synthesis of fluorinated xanthene derivatives
发明人：KLAUBERT DIETER H; GEE KYLE R
权利人:MOLECULAR PROBES INC
摘要:Facile syntheses for fluorinated resorcinol and aminophenol derivatives are provided that yield isomer-free products in good yield. These novel methods use generally available precursors and standard laboratory reagents and equipment to reproducibly produce these synthetically useful reagents in relatively large quantities. The resulting fluorinated resorcinols and aniinophenols possess utility in the preparation of fluorinated fluorescein and rhodol dyes.

专利号:US-4255594-A
优先权日:1979-09-18
标题 :Hydrogenation of halogen-containing carboxylic anhydrides
发明人：NOVOTNY MIROSLAV
权利人:ALLIED CHEM
摘要:A process is described for the heterogeneous hydrogenation of haloalkyl, halocycloalkyl or haloaryl carboxylic anhydrides to the corresponding primary alcohols. In the haloalkyl or halocycloalkyl carboxylic anhydrides at least one halogen is in the alpha-position relative to the carboxylic anhydride grouping. The hydrogenation can be carried out in the liquid or vapor phase in the presence of a supported or unsupported catalyst comprising a member of the group consisting of rhodium, iridium, metal oxides thereof, or mixtures thereof. In the liquid phase, the hydrogenation can be carried out batchwise under mild conditions of temperature and pressure, preferably at about 50°-150° C. and about 5-15 atmospheres, in an atmosphere containing hydrogen gas. A preferred embodiment is the hydrogenation of trifluoroacetic anhydride in the liquid phase to 2,2,2-trifluoroethanol, said alcohol being useful as an intermediate in the synthesis of the anesthetic, isoflurane, CF 3 CHClOCHF 2 .