CAS: 53882-80-7; 2-Bromobenzoylacetonitrile

上下游产品

2-bromobenzoic acid ethyl ester acetonitrile 2-bromobenzoyl cyanide cyanomethyl bromide 2-bromobenzoyldideuterioacetonitrile 5-amino-3-(o-bromophenyl)pyrazole 3-(2-(Methylsulphonyl)phenyl)-3-oxopropanenitrile 4-amino-6-(((1S)-1-(7-fluoro-2-(2-(methylsulfonyl)-phenyl)-1,5-naphthyridin-3-yl)ethyl)amino)-5-pyrimidinecarbonitrile

📜Methyl 3-(2-Bromophenyl)-3-Oxopropanedithioate置于盐酸羟胺,Sodium Hydroxide体系中,用 乙醇 作为反应溶剂,化学反应 1.5H,以63%的收率获得产物2-溴苯甲酰乙腈
参考文献:Divergent Reactivity In The Reaction Of β-Oxodithioesters And Hydroxylamine: Access To β-Ketonitriles And Isoxazoles
标题:Divergent Reactivity In The Reaction Of β-Oxodithioesters And Hydroxylamine: Access To β-Ketonitriles And Isoxazoles
摘要:Starting From Beta-Oxodithioesters And Hydroxylamine,Two Completely Different Transformations Afford Either Beta-Ketonitriles Or Isoxazoles With High Chemoselectivity Depending On The Reaction Conditions. The Reaction Of Beta-Oxodithioesters With Hydroxylamine In Etoh At Room Temperature In Daylight Gave Beta-Ketonitriles In High Yields. On The Other Hand,3-Methylthio-Isoxazoles Were Efficiently Obtained As The Final Products By Heating The Mixture Of Beta-Oxodithioesters And Hydroxylamine In Hoac At 90 Degrees C.
DOI:10.1021/acs.Joc.5B01869