CAS: 52663-67-9; 2,2',3,3',5,5',6-Heptachlorobiphenyl

该化合物是一种多氯联苯同族体,其特征是二苯结构上的七氯替代体,该化合物主要用于研究和分析应用,因为它是环境和毒理学研究的参考标准,其高氯化程度有助于其稳定性和持久性,使其对研究多氯联苯降解,生物累积和环境归宿具有价值.该化合物的界定明确的结构使得能够精确地校准色谱分析,协助在复杂的基质中检测和量化多氯联苯,其使用受到严格监管,因为它具有潜在的毒性和环境影响.

英文名称2,2',3,3',5,5',6-Heptachlorobiphenyl
中文名称2,2',3,3',5,5',6-七氯联苯
IUPAC名称1,2,4,5-tetrachloro-3-(2,3,5-trichlorophenyl)benzene
其它别名2,2',3,3',5,5',6-Heptachlorobiphenyl; 2,3,5,2',3',5',6'-Heptachlorobiphenyl; 2,3,5,6,2',3',5'-Heptachlorobiphenyl
CAS编号52663-67-9
MFCD编号:MFCD00792634
FDA UNII编号:TC6A5D9JJE
分子式:C12H3Cl7分子量:395.32
产品CID: 2496358
产品分类分析化学 → 食品安全 → 二噁英，多氯联苯，呋喃

相似结构搜索
InChIKey: WCIBKXHMIXUQHK-UHFFFAOYSA-N
1S/C12H3Cl7/c13-4-1-5(10(17)6(14)2-4)9-11(18)7(15)3-8(16)12(9)19/h1-3H
计算化学: 氢键受体数*氢键供体数0.0可旋转键数1.0

MSDS等安全信息

危险描述Not Classified
Reported as not meeting GHS hazard criteria by 3 of 3 companies. For more detailed information, please visit ECHA C&L website.
安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)

上下游产品

1,2,4,5-Tetrachloro-3-iodobenzene 1,2,5-trichloro-3-iodobenzene 2,3,5,6-tetrachloroaniline 1,2,4-Trichlorobenzene

合成工艺路线路线简述

📜2,3,5,6-四氯苯胺,三氯苯置于亚硝酸异戊酯体系中,化学反应生成 2,2',3,3',5,5',6-七氯联苯
参考文献:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
标题:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
摘要:Physical,Spectral And Chromatographic Data For All 209 Individual Pcb Congeners Is Presented. The Individual Congeners Were Synthesized And Then Isolated And Purified. Recent Emphasis On The Source Of The Toxicity Of Commercial Pcb Formulations Has Increased The Need For A Complete Set Of The Pcb Congeners. Through The Use Of Two Capillary Gc Columns: 40% octadecyl/ 15% Phenyl Methyl Siloxane And 50% Phenyl Methyl Siloxane,It Was Possible To Separate 201 Pcb Congeners With Only Four Unresolved Pairs. The Data Compiled In This Study For All 209 Congeners Will Aid In The Identification Of Selected Individual Components Of These Environmental Pollutants. The Use Of This Data Also Presents The Opportunity For The Improved Quantification Of The Commercial Pcb Formulations.
DOI:10.1016/0045-6535(95)00140-4