CAS: 34633-34-6; Bifluranol
该化合物是一种合成有机化合物,主要因其在农业应用中作为杀真菌剂的作用而得到承认;它属于化学类的三硝基苯衍生物,以其广谱抗反芬基活动著称;Bifluanol有效抑制了egosterol生物合成,这是真菌细胞膜的一个关键成分,从而干扰真菌的生长和扩散;它的主要优点包括:对一系列病原菌具有很高的功效,全面保护植物的系统行动,以及在各种环境条件下保持稳定;该化合物因其残留活动而特别受到重视,该残留活动提供了长期防止真菌感染的保护;Bifluranol通常用于作物保护方案,以提高产量和质量.
- 英文名称Bifluranol
- 中文名称戊双氟酚
- IUPAC名称4,4'-((2S,3R)-pentane-2,3-diyl)bis(2-fluorophenol)
- 其它别名Erythro-2,3-Bis(3-Fluor-4-Hydroxyphenyl)Pentan; Bifluranolum [inn-Latin]; (2S,3R)-Bifluranol; Bifluranol [inn:Ban]; 4,4'-(2S,3R)-Pentane-2,3-Diylbis(2-Fluorophenol); Bifluranolu
- CAS编号34633-34-6
- MFCD编号:MFCD00864665
- FDA UNII编号:47602X79JF
- 分子式:C17H18F2O2分子量:292.33
- 产品CID: 1350204
- 产品分类Inhibitors/Agonists → Endocrinology/Hormones → Androgen Receptor | Inhibitors/Agonists → Endocrinology/Hormones → ERR
物理性质
合成工艺路线路线简述
海关参考信息
- 2902600000-乙苯
2902700000-异丙基苯
2908199090-其他酚的卤化衍生物
2908999090-其他酚的硝化衍生物 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-9220714-B2
优先权日:2006-03-16
标 题 :Nitrofuran compounds for the treatment of cancer and angiogenesis
发明人：SAULNIER SHOLLER GISELLE L; SWAMY NARASIMHA; KALKUNTE STAYAN; SINGH RAKESH K; BRARD LAURENT; KIM KYU KWANG
权利人:WOMEN AND INFANTS HOSPITAL OF RHODE ISLAND; UNIV BROWN; WOMEN AND INFANTS HOSPITAL RHODE ISLAND
摘要:The invention is directed to the synthesis and use of nitrofuran compounds, especially Nifurtimox, as medicaments to treat cancer, especially neuroblastoma, and to inhibit angiogenesis. The invention also provides compositions, unit dosage forms, and kits comprising the compounds.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Pope DJ, Gilbert AP, Easter DJ, Chan RP, Turner JC, Gottfried S, Parke DV. The metabolism of bifluranol by rat, dog and ferret. J Pharm Pharmacol. 1981 May;33(5):302-8.
3: Pope DJ, Gilbert AP, Easter DJ, Chan RP, Turner JC, Gottfried S, Parke DV. Bifluranol, a novel fluorinated bibenzyl anti-androgen, its chemistry and disposition in different animal species. J Pharm Pharmacol. 1981 May;33(5):297-301.
6: Roesner S, Blair DJ, Aggarwal VK. Enantioselective installation of adjacent tertiary benzylic stereocentres using lithiation-borylation-protodeboronation methodology. Application to the synthesis of bifluranol and fluorohexestrol. Chem Sci. 2015 Jul 1;6(7):3718-3723. doi: 10.1039/c4sc03901g. Epub 2015 Apr 28.
合成参考文献
参考文献:10.1111/j.2042-7158.1981.tb13784.x
摘要:Pope DJ, Gilbert AP, Easter DJ, Chan RP, Turner JC, Gottfried S, Parke DV. Bifluranol, a novel fluorinated bibenzyl anti-androgen, its chemistry and disposition in different animal species. J Pharm Pharmacol. 1981 May;33(5):297–301. doi: 10.1111/j.2042-7158.1981.tb13784.x.
参考文献:10.1111/j.2042-7158.1981.tb13785.x
摘要:Pope DJ, Gilbert AP, Easter DJ, Chan RP, Turner JC, Gottfried S, Parke DV. The metabolism of bifluranol by rat, dog and ferret. J Pharm Pharmacol. 1981 May;33(5):302–8. doi: 10.1111/j.2042-7158.1981.tb13785.x.
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