CAS: 34328-46-6; 4-Chloro-3-(Trifluoromethyl)Benzaldehyde

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CAS号445-01-2 5-溴-2-氯三氟甲苯 | CAS号75-17-2 甲醛肟(10%的水溶液,约2.... | CAS号320-51-4 5-氨基-2-氯三氟甲苯 | CAS号65735-71-9 4-氯-3-三氟甲基苄醇 | CAS号132604-91-2 3-[4-chloro-3-(... | CAS号348-84-5 1-[4-氯-3-(三氟甲基)...

5-溴-2-氯三氟甲苯置于磺酰氯,水,Silica Gel,Magnesium体系中,用 四氢呋喃,氯仿 作为反应溶剂,化学反应 7.0H,反应生成 4-氯-3-三氟甲基苯甲醛
参考文献:Antimalarial Drugs. 64. Synthesis And Antimalarial Properties Of 1-Imino Derivatives Of 7-Chloro-3-Substituted-3,4-Dihydro-1,9(2H,10H)-Acridinediones And Related Structures
标题:Antimalarial Drugs. 64. Synthesis And Antimalarial Properties Of 1-Imino Derivatives Of 7-Chloro-3-Substituted-3,4-Dihydro-1,9(2H,10H)-Acridinediones And Related Structures
摘要:To Improve Upon The Activity And Properties Of The 3-Aryl-7-Chloro-3,4-Dihydro-1,9(2H,10H)-Acridinediones,A Variety Of 1-[(Alkylamino)Alkylene]Imino Derivatives (3) Were Prepared And Shown To Be Highly Active Antimalarial Agents In Both Rodents And Primates. Among Structural Modifications Prepared,Including N-10-Alkyl And C2-Substituted Analogs,Removal Of The C-9 Oxygen,And Introduction Of An Imino Side Chain At C-9,The Imines Of The N-10-H Acridinediones Were The Most Active Compounds Obtained. The [3-(Nn-Dimethylamino)Propyl]Imino Derivative Of 7-Chloro-3-(2,4-Dichlorophenyl)-3,4-Dihydro-1,9(2H,10H)-Acridinedione (9Aa) Proved To Be Highly Active In Advanced Studies In Primates.
DOI:10.1021/jm00097A001

专利信息

专利号:US-9751877-B2
优先权日:2012-09-21
标题 :Substituted pyrido[1,2-a]pyrazines for the treatment of neurodegenerative and neurological disorders
发明人：PETTERSSON MARTIN YOUNGJIN; JOHNSON DOUGLAS SCOTT; SUBRAMANYAM CHAKRAPANI; O'DONNELL CHRISTOPHER JOHN; AM ENDE CHRISTOPHER WILLIAM; GREEN MICHAEL ERIC; PATEL NANDINI CHATURBHAI; STIFF CORY MICHAEL; TRAN TUAN PHONG; KAUFFMAN GREGORY WAYNE; STEPAN ANTONIA FRIEDERIKE; VERHOEST PATRICK ROBERT
权利人:PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:US-9446047-B2
优先权日:2013-09-10
标 题 :Substituted 2,3-dihydro-1H-inden-1-one retinoic acid-related orphan nuclear receptor antagonists for treating multiple sclerosis
发明人：VANKAYALAPATI HARIPRASAD; YERRAMREDDY VENKATAKRISHNAREDDY
权利人:ARRIEN PHARMACEUTICALS LLC
摘要:The present invention is directed to compounds, their synthesis, and their use as antagonists, inverse agonists, modulators and or inhibitors of the Retinoic acid-related orphan nuclear receptor γt (RORγt)/RORγ. The compounds of the present invention are useful for modulating RORγt)/RORγ activity and for treating diseases or conditions mediated by RORγt)/RORγ such as for example, disease states associated with immunopathology of human autoimmune diseases such as Multiple Sclerosis (MS), Rheumatoid Arthritis (RA), Inflammatory Colitis, Psoriasis, COPD, Pain, Obesity, Diabetes, Dyslipidemia, Osteoporosis, Asthma, Neurodegenerative diseases and Cancer.