CAS: 2762-32-5; Piperazine-2-Carboxylic Acid

该化合物是一种有机化合物,其特征是其管子环结构,附着在第二个位置上,一个碳酸的功能组;它是在水和极有机溶剂中溶解的白色晶体固体,反映了由于碳酸组的极性;该化合物由于存在可参与氢联结和与各种生物系统互动的管子松酸而具有基本特性. 2-Piperazinecarboxylic 酸,经常用于合成药物和农用化学品,作为生产各种生物活性化合物的中间体.其衍生物可能展示出一系列生物活动,包括抗微生物和抗炎性特性.此外,该化合物的结构允许进行可能的修改,使其成为医药化学中有价值的建筑块.安全数据表明,与许多化学物质一样,它应当谨慎处理,并遵循适当的安全议定书,以减少与接触有关的风险.

结构式图片

相似化合物

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合成工艺路线路线简述

    Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于palladium On Activated Charcoal,水体系中,化学反应生成2-哌嗪羧酸盐酸盐
    参考文献:Felder Et Al.,Chimia,1959,Vol. 13,P. 263
    标题:Felder Et Al.,Chimia,1959,Vol. 13,P. 263

    海关参考信息

    专利信息


    专利号:US-7138526-B1
    优先权日:1999-06-15
    标 题 :Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives
    发明人:HERPIN TIMOTHY F; MORTON GEORGE C; SALVINO JOSEPH M
    权利人:AVENTIS PHARMA INC
    摘要:A method for the solid phase synthesis of N,N-disubstituted diazacycloalkylcarboxy derivatives of general formula (I) and (II) is claimed. Examples include piperazine-2-carboxamide. The method is applicable to the synthesis or large combinatorial libraries

    专利号:US-7495123-B2
    优先权日:2004-04-05
    标 题:Process for the preparation of enantiomerically enriched beta amino acid derivatives
    发明人:XIAO YI; SUN YONGKUI; ROSNER THORSTEN; RIVERA NELO R; KRSKA SHANE W; CLAUSEN ANDREW M; ARMSTRONG III JOSEPH D; SPINDLER FELIX; MALAN CHRISTOPHE
    权利人:SOLVIAS AG; MERCK & CO INC
    摘要:The present invention relates to a process for the efficient preparation of enantiomerically enriched beta amino acid derivatives wherein the amino group is unprotected. The product chiral beta amino acid derivatives are useful in the asymmetric synthesis of biologically active molecules. The process comprises an enantioselective hydrogenation of an amine-unprotected prochiral beta-amino acrylic acid or derivative thereof in the presence of a rhodium metal precursor complexed with a chiral mono- or bisphosphine ligand.

    专利号:US-2023364251-A1
    优先权日:2020-08-06
    标 题:Methods for the synthesis of protein-drug conjugates
    发明人:BORCHARDT ALLEN; HUGHES ROBERT MICHAEL
    权利人:CIDARA THERAPEUTICS INC
    摘要:The present invention relates to intermediates and methods for synthesizing protein-drug conjugates that can be used for the treatment of diseases and related conditions.

    专利号:US-2012115907-A1
    优先权日:2009-04-24
    标题 :Novel compounds as inhibitors of renin
    发明人:THOMBARE PRAVAIN; DESAI JIGAR; JAIN MUKUL R
    权利人:THOMBARE PRAVAIN; DESAI JIGAR; JAIN MUKUL R; CADILA HEALTHCARE LTD
    摘要:The present invention relates to novel renin inhibitors of general formula (1), novel intermediates involved in their synthesis, their pharmaceutically acceptable salts and pharmaceutical compositions containing them. The present invention also relates to a process of preparing compounds of general formula (1), their tautomeric forms, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and novel intermediates involved in their synthesis.

    专利号:RU-2125561-C1
    优先权日:1993-07-16
    标 题:Intermediate compounds for synthesis of hiv-protease inhibitors and a method of their synthesis

    专利号:WO-2013084241-A1
    优先权日:2011-12-09
    标题:Compounds as inhibitors of renin
    发明人:THOMBARE PRAVIN S; DESAI JIGAR N
    权利人:CADILA HEALTHCARE LTD; THOMBARE PRAVIN S; DESAI JIGAR N
    摘要:The present invention relates to novel renin inhibitors of general formula (1), novel intermediates involved in their synthesis, their pharmaceutically acceptable salts and pharmaceutical compositions containing them. The present invention also relates to processes for preparing compounds of general formula (1), their tautomeric forms, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and novel intermediates involved in their synthesis.
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    合成参考文献


    参考文献:10.1007/bf01388175
    摘要:Palomo C, Aizpurua JM, Ganboa I, Oiarbide M. From beta-lactams to alpha- and beta-amino acid derived peptides. Amino Acids. 1999;16(3-4):321–43. doi: 10.1007/bf01388175.
    摘要:Wu G, Zhao H, Luo RG, Wei D, Malhotra SV. Chiral synthesis and enzymatic resolution of (S)-(-)piperazine-2-carboxylic acid using enzyme alcalase. Enantiomer. 2001;6(6):343–5.
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