专利号:US-6506915-B1 优先权日:2001-06-14 标 题 :Synthesis of coenzyme Q10 ubiquinone 发明人:WEST DANIEL DAVID 摘要:Processes for the stereospecific synthesis of coenzyme Q10, ubiquinone, are disclosed; a total synthetic procedure using geraniol as the starting material. The process of the invention results in high yields of isometrically pure ubiquinone. The synthetic coenzyme Q10 can be used as an antioxidant, a nutritional supplement and as a pharmaceutical in treating many conditions.
专利号:US-2025115629-A1 优先权日:2021-03-18 标 题 :Chiral synthons for the synthesis of chiral phosphorothioates 发明人:ZHANG YONGDA; WU LINGLIN 权利人:BOEHRINGER INGELHEIM INT 摘要:This invention relates to compounds of Formula (I) useful as synthons for a general synthetic method for making chiral phosphorothioates, to their preparation and to their use in a robust large scale process for making P-chiral phosphorothioates.
专利号:US-8889851-B2 优先权日:2011-11-30 标题:Methods for the synthesis and purification of oligomers 发明人:LEPROUST EMILY MARINE; LACKEY JEREMY 权利人:AGILENT TECHNOLOGIES INC 摘要:A reagent for oligonucleotide synthesis or purification, wherein the reagent has a structure of:n nX—C—L—H  (Formula A)n nwherein X is a phosphoramidite group, an H-phosphonate group, an acetal group, or an isocyanate; C is a direct bond or a cleavable adaptor represented by —C a —C b —; L is a hydrocarbyl chain; and H is a terminal alkyne or an activated cyclooctyne. The reagent of Formula (A) can be used in the synthesis and purification of oligonucleotides.
专利号:WO-2022194924-A1 优先权日:2021-03-18 标 题:Chiral synthons for the synthesis of chiral phosphorothioates
专利号:EP-4308580-A1 优先权日:2021-03-18 标 题:Chiral synthons for the synthesis of chiral phosphorothioates
专利号:CN-116981677-A 优先权日:2021-03-18 标 题:Chiral synthons for the synthesis of chiral phosphorothioates