CAS: 23111-00-4; 3-Carbamoyl-1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-yl)Pyridin-1-Ium Chloride

相似化合物

17720-18-2 1094-61-7 78687-39-5

上下游产品

5',3',2'-tri-O-acetyl-1-β-D-ribofuranosylnicotinamide chloride O-benzoyl-β-D-ribofuranosyl)-pyridinium; chloride3-carbamoyl-1-(tri-O-benzoyl-β-D-ribofuranosyl)-pyridinium; chloride 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose 2,3,5-tri-O-acetyl-α-D-ribofuranosyl chloridenicotinamide mononucleotide 1-[(2R,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofur-2-yl]-1,4-dihydropyridine-3-carboxamide

烟酰胺置于盐酸体系中,用 甲醇,乙醇,乙腈 用作溶剂,20.0 °C,101.33 Kpa 条件下,反应 0.33H,反应生成烟酰胺核苷
参考文献:烟酰胺核糖的新结晶盐作为食品添加剂
标题:烟酰胺核糖的新结晶盐作为食品添加剂
摘要:Nr +是一种高效的维生素b 3型补充剂,因为它具有补充nad +含量的独特能力.尽管nr +氯化物已作为营养补充剂投放市场,但其合成具有挑战性,价格昂贵且收率低,这使其在大规模工业生产中变得麻烦.在这里,我们报告了新型结晶性nr +盐,D / L / Dl-酒石酸氢盐和d / L / Dl-苹果酸氢盐.它们的高产量一锅法生产不需要特定的设备,并且适合于多吨规模的生产.与批准的nr +相比,这些新的nr +盐具有生物等效性,因此似乎非常适合营养应用氯化物.另外,给出了nr +酒石酸氢盐和nr +苹果酸氢盐的所有立体异构体的晶体结构以及与已知的nr +卤化物的比较.
Doi:10.3390/molecules26092729

专利信息

专利号:US-2024247022-A1
优先权日:2021-05-04
标 题 :A Process for Synthesis of Nicotinamide Riboside Chloride (NRCL)
发明人：MALKANNAGARI RAMANI; GUNDAPUNENI RAGHAVA RAO; BOHAN FRODE
权利人:BOHAN & CO AS
摘要:The present invention discloses synthesis of nicotinamide riboside chloride (NRCI). More particularly, the present invention describes cost effective and industrially scalable process for the synthesis of NRCI in amorphous form.

专利号:US-11629163-B2
优先权日:2017-06-30
标题:Methods of synthesizing nicotinamide riboside
发明人：MARCOTULLI ERIC; ALMINANA DAN; DELLINGER RYAN; MORRIS MARK; THAMATAM RAJESH
权利人:ELYSIUM HEALTH INC
摘要:Provided herein are efficient and scalable methods for the synthesis of nicotinamide riboside from riboside triacetate. Also provided are compositions comprising nicotinamide riboside, and therapeutic methods employing nicotinamide riboside.

专利号:US-2024216412-A1
优先权日:2022-11-22
标 题 :Oxidized nicotinamide adenine dinucleotide (nad+) precursor treatment for heart failure alleviation independent of mitochondrial protein deacetylation
发明人：TIAN RONG; WALKER MATTHEW
权利人:UNIV WASHINGTON
摘要:The current disclosure provides provides boosting intracellular NAD + with nicotinamide riboside chloride (NR) to protect from cardiac dysfunction, NR being a natural NAD + precursor that bypasses nicotinamide phosphoribosyltransferase (NAMPT) to stimulate intracellular NAD + synthesis.

专利号:CN-119144473-A
优先权日:2024-11-18
标题 :A Saccharomyces cerevisiae strain and its application in efficient synthesis of β-NMN

专利号:WO-2022233923-A1
优先权日:2021-05-04
标题:A process for synthesis of nicotinamide riboside chloride (nrcl)

专利号:EP-4320137-A1
优先权日:2021-05-04
标 题 :A process for synthesis of nicotinamide riboside chloride (nrcl)